Type 2 Diabetes Risk Up With PCOS Regardless of BMI
PCOS one of most influential predictors of T2DM after adjustment for BMI, education, family history
(HealthDay News) -- Irrespective of age and weight, women with polycystic ovary syndrome (PCOS) have an increased risk for type 2 diabetes, according to a study published online in Diabetes Care.
Nadira S. Kakoly, MPH, from Monash University in Melbourne, Australia, and colleagues estimated nationwide incidence rates and predictors of type 2 diabetes using data from the Australian Longitudinal Study on Women's Health (2000 to 2015) database for women aged 18 to 42 years.
The researchers found that 186 women developed type 2 diabetes over a follow-up of 1919 person-years (PYs). In PCOS and control subjects, the incidence rate was 4.19 and 1.02 per 1000 PYs, respectively. The incidence rates of type 2 diabetes were 3.21, 4.67, and 8.8 on subgroup analyses for healthy-weight, overweight, and obese categories of women, respectively; in PCOS versus age-matched controls, the corresponding incidence rate ratios were 4.68, 3.52, and 2.36. After adjustment for body mass index, education, area of residence, and family history of type 2 diabetes, PCOS was one of the most influential predictors of type 2 diabetes in the entire cohort (hazard ratio, 3.23).
"Based on the moderate absolute clinical risk demonstrated here, guideline recommendations should consider type 2 diabetes screening in all women with PCOS at least every 3 years from early adulthood, depending on local resources and patient preference," the authors write.
Kakoly NS, Earnest A, Teede HJ, Moran LJ, and Joham AE. The Impact of Obesity on the Incidence of Type 2 Diabetes Among Women With Polycystic Ovary Syndrome. Diabetes Care 2019 Jan;dc181738. Diab Care. DOI:10.2337/dc18-1738