No Reduced CVD Risk for SBP <120 mm Hg in Type 2 Diabetes
Increased risk of CVD for achieved systolic blood pressure of <120 versus <130 or <140 mm Hg
(HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), there is no reduction in cardiovascular disease (CVD) risk with achieved systolic blood pressure (SBP) of <120 mm Hg vs <130 or <140 mm Hg, according to a study published online in Diabetes Care.
Eric Yuk Fai Wan, from the University of Hong Kong, and colleagues conducted a retrospective cohort study of 28,014 primary care adult patients with T2DM with no prior CVD diagnosis. The authors identified a total of 2079, 10,851, and 15,084 matched patients with achieved SBP measurements of <120, <130, and <140 mm Hg, respectively.
The researchers found that the incidence of CVD was 15.3, 9.1, and 10.8% in patients who achieved SBP measures of <120, <130, and <140 mm Hg, respectively, over a median follow-up of 4.8 years (incidence rates, 34.3, 20.4, and 21.4 per 1000 person-years, respectively). Compared with achieved SBP <130 mm Hg and achieved SBP of <140 mm Hg, achieved SBP <120 mm Hg was correlated with an increased risk of CVD (hazard ratios, 1.75 and 1.67, respectively). A significant reduction in CVD risk was seen for patients aged <65 years with achieved SBP <130 vs <140 mm Hg (hazard ratio, 0.81).
"Our findings support a SBP treatment target of 140 mm Hg and suspect no risk reduction attenuation on CVD for lower SBP targets," the authors write.
Yuk Fai Wan E, Yee Tak Yu E, Yee Chin W, et al. Effect of Achieved Systolic Blood Pressure on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus: A Population-Based Retrospective Cohort Study. Diab Care 2018 Mar;dc172443. DOI:10.2337/dc17-2443