Insulin Needed for T2DM Tx Set to Increase >20 Percent by 2030
Using higher HbA1c target in over-75s could increase disability-adjusted life-years by 44.2%.
(HealthDay News) -- From 2018 to 2030, the insulin required to treat type 2 diabetes is expected to increase more than 20%, according to a study published online in The Lancet Diabetes & Endocrinology.
Sanjay Basu, PhD, from Stanford University in Palo Alto, California, and colleagues developed a microsimulation of the type 2 diabetes burden from 2018 to 2030 across 221 countries to compare alternative projections for and consequences of insulin use worldwide.
The researchers found that from 2018 to 2030, the number of people with type 2 diabetes was estimated to increase from 405.6 million to 510.8 million. Accordingly, insulin use is expected to increase from 516.1 million to 633.7 million 1,000-IU vials per year. Without an improvement in access to insulin, 7.4% of people with type 2 diabetes would use insulin in 2030; this%age would increase to 15.5% with widely accessible insulin access, prescribed to achieve a hemoglobin A1c (HbA1c) level of ≤7%. Insulin would avert 331,101 disability-adjusted life-years (DALYs) per year by 2030 if an HbA1c of ≤7% was universally achieved. With access to newer oral antihyperglycemic drugs, DALYs averted would increase by 14.9%. If an HbA1c of 8% was used as a target among people aged 75 years and older, DALYs averted would increase by 44.2%.
"These estimates suggest that current levels of insulin access are highly inadequate compared to projected need," Basu said in a statement.
Basu S, Yudkin John S, Kehlenbrink S, et al. Estimation of global insulin use for type 2 diabetes, 2018–30: a microsimulation analysis. Lancet. DOI:10.1016/S2213-8587(18)30303-6
Gerstein HC. Insulin use for type 2 diabetes: the challenges of predicting trends and modelling care. Lancet. DOI:10.1016/S2213-8587(18)30312-7