Diabetes News Archive

Metformin Can Be Used Safely at Lower Levels of Renal Function

Metformin Can Be Used Safely at Lower Levels of Renal Function

New study shows metformin is not associated with an increased risk of acidosis in patients with type 2 diabetes and an eGFR of 30 to 60 mL/min/1.73 m2.

Elevated HbA1c Usually Leads to Prompt Tx Start, Intensification

Elevated HbA1c Usually Leads to Prompt Tx Start, Intensification

Within 6 months of elevated HbA1c, rate of initiation 63%, rate of intensification 82%.

ESRD Risk Small Among Type 2 Diabetics

ESRD Risk Small Among Type 2 Diabetics

Type 2 diabetes is among the leading causes of end-stage renal disease (ESRD), but the estimated cumulative risk of ESRD at 20 years after diagnosis of type 2 diabetes is less than 1%.

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

2003 to 2014 Saw Rise in Diabetic Ketoacidosis Admissions

Decrease in length of stay and mortality, but increase in mean hospital charges during study period.

Glyburide Not Noninferior to Insulin for Gestational Diabetes

Glyburide Not Noninferior to Insulin for Gestational Diabetes

Frequency of primary outcome was 27.6 and 23.4% in glyburide and insulin groups, respectively.

Perioperative MACCEs More Common With Diabetes

Perioperative MACCEs More Common With Diabetes

Major adverse CV and cerebrovascular events with noncardiac sx have also increased in DM patients

Aortic Stiffness, Concentric LV Remodeling Linked in T2DM

Aortic Stiffness, Concentric LV Remodeling Linked in T2DM

Aortic distensibility independently linked to concentric left ventricular remodeling

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Evening Preference Linked to Higher BMI in Type 2 Diabetes

Breakfast time mediates the association between morning-evening preference and BMI

Few US Adults Meet Most T2DM Risk Reduction Goals

Few US Adults Meet Most T2DM Risk Reduction Goals

Overall, 21, 29, and 13% meet goals for fruit, vegetable, and dairy intake, respectively

No Reduced CVD Risk for SBP 120 mm Hg in Type 2 Diabetes

No Reduced CVD Risk for SBP <120 mm Hg in Type 2 Diabetes

Increased risk of CVD for achieved systolic blood pressure of 120 versus 130 or 140 mm Hg

Fenofibrate Therapy Slows CKD Progression in Diabetics

Fenofibrate Therapy Slows CKD Progression in Diabetics

In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.

Most Disliked Dialysis Dietary Restriction Is Limited Fluid Intake

Most Disliked Dialysis Dietary Restriction Is Limited Fluid Intake

In a survey, nearly one-third of hemodialysis patients said they disliked fluid restriction.

DPP-4I Not Tied to Increased Risk of Acute Pancreatitis in Seniors

DPP-4I Not Tied to Increased Risk of Acute Pancreatitis in Seniors

Among adults with heart disease, risk increased with DPP-4I vs thiazolidinedione not sulfonylureas

Diabetes, HbA1c Linked to Adverse Outcomes After Surgery

Diabetes, HbA1c Linked to Adverse Outcomes After Surgery

DM tied to 6-month mortality, major complications, ICU admission, mechanical ventilation, LOS

Weight Loss Intervention Reduces Long-Term Disability in Diabetes

Weight Loss Intervention Reduces Long-Term Disability in Diabetes

10-year lifestyle, weight loss changes increased disability-free years in women, those without CVD

DPP-4 Inhibitors Linked to Inflammatory Bowel Disease

DPP-4 Inhibitors Linked to Inflammatory Bowel Disease

Higher risk of inflammatory bowel disease with longer use of dipeptidyl peptidase-4 inhibitor

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

AKI hospitalizations were 4 times more likely among patients with diabetes.

Grilled Meats Increase Type 2 Diabetes Risk

Grilled Meats Increase Type 2 Diabetes Risk

Using open flames or high temps to cook red meat, chicken both linked to higher risk of T2DM

Intranasal Insulin Appears Safe

Intranasal Insulin Appears Safe

However, more data is needed on the long-term safety of chronic intranasal insulin administration

ACP Update: HbA1c Targets for Glycemic Control in Type 2 Diabetes

ACP Update: HbA1c Targets for Glycemic Control in Type 2 Diabetes

Clinicians should personalize glycemic control goals; aim for HbA1c of 7 to 8% for most adults.

Diabetes Reclassified Into 5 Groups

Diabetes Reclassified Into 5 Groups

These clusters show differing disease progression and risk of diabetic complications

Fenofibrate Has Wide Range of Treatment Effects in T2DM

Fenofibrate Has Wide Range of Treatment Effects in T2DM

Treatment effect is greater in patients with dyslipidemia; absolute risk reduction of 2.15%

Early-Onset Type 2 Diabetes Tied With Increased Mortality Risk

Early-Onset Type 2 Diabetes Tied With Increased Mortality Risk

Earlier diagnosis of T2DM tied to increased mortality, mainly driven by cardiovascular disease mortality

GFR Decline Tied to Protein Intake in Diabetic Blacks

GFR Decline Tied to Protein Intake in Diabetic Blacks

The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.

Prediabetes Diagnosed by A1c Tied With Excess Risks

Prediabetes Diagnosed by A1c Tied With Excess Risks

Prediabetes measured by FPG, 2-hour plasma glucose not linked to increased risk of major event.

Perioperative Glucose Not A1c Predicts Death

Perioperative Glucose Not A1c Predicts Death

A1C is not associated with increased 30-day mortality after controlling for glucose

Ertugliflozin May Improve Glycemic Control in Type 2 Diabetes

Ertugliflozin May Improve Glycemic Control in Type 2 Diabetes

Improvement in glycemic control, reduction in body weight, SBP; increase in genital mycotic infections.

Rotating Night Shift Work May Up Risk for Type 2 Diabetes

Rotating Night Shift Work May Up Risk for Type 2 Diabetes

Working more night shifts per month linked to increased odds of type 2 diabetes

Abnormalities Present Decades Before Diabetes Diagnosis

Abnormalities Present Decades Before Diabetes Diagnosis

Subtle elevations in fasting glucose and triglycerides associated with developing type 2 diabetes

Death Risk Up in Diabetes With Low eGFR, No Albuminuria

Death Risk Up in Diabetes With Low eGFR, No Albuminuria

Mortality rates increasing among those with albumin-to-creatinine ratio 30 mg/g and low eGFR

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

Risk scores summarizing 8 diseases, markers tied to cancer risk in dose-response manner

Unstable Housing May Up Diabetes-Related Emergency Visits

Unstable Housing May Up Diabetes-Related Emergency Visits

Also linked to increased rate of hospitalization; very few receive help with housing through their clinic

Diabetes Patients at Greater Risk for Serious Infection

Diabetes Patients at Greater Risk for Serious Infection

Findings demonstrate an important population burden, including hospitalization and death.

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

AKI associated with 27% increased risk of hypoglycemia among patients with diabetes.

Diabetes, Prediabetes History Linked to Calcified Plaque

Diabetes, Prediabetes History Linked to Calcified Plaque

Diabetes and prediabetes duration also tied to worse subclinical systolic function, diastolic relaxation.

Excess Mortality Found for All BMIs in Type 2 Diabetes

Excess Mortality Found for All BMIs in Type 2 Diabetes

Nadir at BMI of 25 to 30 kg/m stepwise increase to peak for patients with BMI 40 kg/m

Device May Improve Extendin-4 Delivery in Type 2 Diabetes

Device May Improve Extendin-4 Delivery in Type 2 Diabetes

System allows glucose-responsive, closed-loop release to improve therapeutic performance of Ex4.

Study: ESRD Risk in Type 1 Diabetes Pts Has Declined

Study: ESRD Risk in Type 1 Diabetes Pts Has Declined

Relative risk of end-stage renal disease was 0.13 in those diagnosed in 1995-2011 versus 1965-1979.

More Than One in Five US Veterans Has Diabetes

More Than One in Five US Veterans Has Diabetes

Over 20% of US veterans were diagnosed with diabetes from 2013 to 2014.

Stricter Glycemic Control May Up Remission in New-onset Type 2 Diabetes

Stricter Glycemic Control May Up Remission in New-onset Type 2 Diabetes

Newly diagnosed T2D patients who strictly maintain glycemic targets may go into remission in 1 year.

Adopting a Healthy Lifestyle Effectively Reduces Diabetes

Adopting a Healthy Lifestyle Effectively Reduces Diabetes

Reduced incidence seen with lifestyle changes, meds; however, effect of meds is short-lived.

Some High-risk Heart Failure Patients Benefit From MRAs

Some High-risk Heart Failure Patients Benefit From MRAs

Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.

Delayed-release Niacin Benefits Prediabetes, Diabetes

Delayed-release Niacin Benefits Prediabetes, Diabetes

Delayed-release Niacin may be beneficial to patients with prediabetes and type 2 diabetes.

Dietary Fat Cuts HbA1c-Lowering Effect of DPP4i Monotherapy

Dietary Fat Cuts HbA1c-Lowering Effect of DPP4i Monotherapy

Saturated fat intake significantly decreases in HbA1c-lowering effect in DPP4i monotherapy in patients with diabetes.

Lower BP Targets Reduce Cardiovascular Events Risk

Lower BP Targets Reduce Cardiovascular Events Risk

Intensive BP drops may lower cardiovascular risks in both patients with and without diabetes.

Pre-Op Liraglutide Reduces Post-Op Plasma Glucose in Diabetes Pts

Pre-Op Liraglutide Reduces Post-Op Plasma Glucose in Diabetes Pts

In patients with T2DM, taking liraglutide before surgery may be associated with reduced post-op plasma glucose levels.

TIMI Risk Score Predicts Atherothrombotic Disease in Type 2 Diabetes

TIMI Risk Score Predicts Atherothrombotic Disease in Type 2 Diabetes

Atherothrombotic disease risk assessment based upon 10 readily available clinical variables.

More Intense Treatment, Worse Quality of Life in Diabetes

More Intense Treatment, Worse Quality of Life in Diabetes

Measuring the quality of life and status of health is imperative in patients with diabetes.

FDA Approves Short Acting Insulin Drug for Diabetes

FDA Approves Short Acting Insulin Drug for Diabetes

The FDA just approved a new short-acting insulin drug, Admelog, for patients with either T1D or T2D.

Primary Care-led Weight Loss Leads to T2DM Remission

Primary Care-led Weight Loss Leads to T2DM Remission

Remission was linked to 46% patients in intensive weight management programs.

FDA Approves Semiglutide for Type 2 Diabetes

FDA Approves Semiglutide for Type 2 Diabetes

Semaglutide helps patients with diabetes reduce blood glucose levels and lower body weight.

Antibiotic-Diabetes Link Questioned

Antibiotic-Diabetes Link Questioned

Lifestyle and clinical factors could have been misinterpreted, linking antibiotics to risk of diabetes.

Greater Adherence With Certain Type 2 Diabetes Meds

Greater Adherence With Certain Type 2 Diabetes Meds

Sulfonylureas and thiazolidinediones adherence was stronger than metformin adherence.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Severe Hypoglycemia a Red Flag for Cardiovascular Risks

Severe Hypoglycemia a Red Flag for Cardiovascular Risks

Severe hypoglycemia is associated with coronary heart disease, cardiovascular mortality, and cancer mortality.

Diabetes Disparities Tied to Chemically Induced Endocrine Inhibition

Diabetes Disparities Tied to Chemically Induced Endocrine Inhibition

Chemicals that inhibit endocrine functions may be associated with contrasts in diabetes-linked racial and socioeconomic disparities.

Diabetes With High BMI Ups Risk of Some Cancers

Diabetes With High BMI Ups Risk of Some Cancers

The combined effects of high BMI and diabetes resulted in 5.6% of all incident cancers in 2012.

CVD Hospitalization Rates Have Declined for Diabetes Patients

CVD Hospitalization Rates Have Declined for Diabetes Patients

For patients with diabetes, there was a significant decrease in hospitalization rates for acute coronary syndrome, cardiac dysrhythmia, heart failure, and certain strokes.

Increasing β-blocker Dose May Lower Death Risk in CHF With Diabetes

Increasing β-blocker Dose May Lower Death Risk in CHF With Diabetes

Effect is larger in chronic heart failure patients with diabetes than CHF patients without diabetes.

Type 2 Diabetes Trends: Metformin Use Up, Sulfonylurea Use Down

Type 2 Diabetes Trends: Metformin Use Up, Sulfonylurea Use Down

But sulfonylureas still most common drugs initiated as second-line treatment.

No Improvement in Glycemic Control in Recent Decade

No Improvement in Glycemic Control in Recent Decade

But significant improvements in HbA1c testing and awareness seen, except in those aged 20 to 44.

Sudden Cardiac Death Risk Increased for Children With Diabetes

Sudden Cardiac Death Risk Increased for Children With Diabetes

Increased risk seen for both all-cause mortality, sudden cardiac death in young people with diabetes.

ESRD Risk Low for Type 1 Diabetes

ESRD Risk Low for Type 1 Diabetes

Findings among a large study of Norwegian children followed for 40-plus years.

Hypertension, Diabetes at Hemodialysis Initiation Increasing

Hypertension, Diabetes at Hemodialysis Initiation Increasing

From 1995 to 2015, the prevalence of hypertension and diabetes among patients starting hemodialysis increased from 67.9% to 87.6% and from 43.1% to 59.6%, respectively.

Statins May Raise Odds of Type 2 Diabetes in Those at High Risk

Statins May Raise Odds of Type 2 Diabetes in Those at High Risk

In any Diabetes Prevention Program treatment group, statin use tied to increased diabetes risk.

Most Type 1 Diabetes Patients Have Kidney Disease

Most Type 1 Diabetes Patients Have Kidney Disease

Incidence of end-stage renal disease has declined but affects substantial portion of long-term T1D patients.

Sudden Cardiac Death Top Culprit in Diabetes With Atherosclerosis

Sudden Cardiac Death Top Culprit in Diabetes With Atherosclerosis

27% of CV deaths in diabetes patients with atherosclerotic CVD are categorized as sudden death.

New Guidelines Released for Type 2 Diabetes

New Guidelines Released for Type 2 Diabetes

Individualized management should include education, glycemic management plans, target HbA1c.

Hospitalization, Death in Heart Failure Modified by HbA1c

Hospitalization, Death in Heart Failure Modified by HbA1c

Stratification of T2D by HbA1c shows U-shaped associations for first hospitalization and mortality.

Greater Heart Disease Benefits From Yoga Aerobics Combo

Greater Heart Disease Benefits From Yoga Aerobics Combo

Greater improvement in CHD risk factors for combined intervention versus either alone.

Oral Semaglutide Increases Glycemic Control in Type 2 Diabetes

Oral Semaglutide Increases Glycemic Control in Type 2 Diabetes

Phase 3 studies next to assess longer-term/clinical outcomes, safety.

Oral Hypoglycemic Drugs With Insulin Lower HbA1c in Type 2 Diabetes

Oral Hypoglycemic Drugs With Insulin Lower HbA1c in Type 2 Diabetes

Adding sulfonylurea or metformin to insulin decreases HbA1c about 1

Case: Venovenous Hemodiafiltration Resolves Metformin Overdose

Case: Venovenous Hemodiafiltration Resolves Metformin Overdose

Case report describes treatment of female patient who attempted suicide with metformin overdose.

DPP4i Plus AGI Ups Glycemic Control in Type 2 Diabetes

DPP4i Plus AGI Ups Glycemic Control in Type 2 Diabetes

Greater drop in HbA1c with DPP4i added to alpha glucosidase inhibitor, with no increase in weight.

Insulin Dose Does Not Reflect Cardiovascular Events

Insulin Dose Does Not Reflect Cardiovascular Events

Similar findings among individuals with diabetes able to achieve normoglycemia.

Weight Loss Underappreciated for Type 2 Diabetes Remission

Weight Loss Underappreciated for Type 2 Diabetes Remission

Primary aim of diagetes management is lowering blood glucose or glycated hemoglobin (HbA1c) concentrations.

First-line Diabetes Rx Failure Attributed to Nonadherence

First-line Diabetes Rx Failure Attributed to Nonadherence

Second-line treatment often initiated without evidence of recommended use of first-line treatment.

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Sensor-based Glucose Monitoring System Avoids Finger Pricks

Instead, sensor is implanted below skin in patients with diabetes.

Many Medicare Recipients Overtreated for Diabetes

Many Medicare Recipients Overtreated for Diabetes

Study of Medicare patients shows overtreatment for diabetes is rarely deintensified.

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

Anagliptin Improves LDL Partly Via ApoB-100 Suppression

The results demonstrated a tendency for a decrease in LDL-C level at 24 weeks in the ANA group, and improvement was mediated through the suppression of apoB-100 synthesis.

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Exenatide Does Not Increase Cardiovascular Risk in Type 2 Diabetes

Administration of exenatide in patients with type 2 diabetes at a wide range of cardiovascular risk appeared not to cause an increase in their overall cardiovascular risk.

2017 Standards of Medical Care in Diabetes Updated

2017 Standards of Medical Care in Diabetes Updated

This synopsis focuses on recommendations from the 2017 Standards of Care about monitoring and pharmacologic approaches to glycemic management for type 1 diabetes.

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

Diacerin Reduces HbA1c Levels in Type 2 Diabetes

The researchers found that, compared with placebo, diacerein reduced HbA1c by 0.35% in the intention-to-treat analysis and by 0.41% in the per-protocol analysis.

Falling Insulin Requirement May Signal Placental Dysfunction

Falling Insulin Requirement May Signal Placental Dysfunction

Among pregnant women with FIR at 25, 30, and 36 weeks, the ratio of soluble fms-like tyrosine kinase 1 to placental growth factor was significantly higher.

Alcohol Consumption May Guard Against Diabetes

Alcohol Consumption May Guard Against Diabetes

Frequent consumption of alcohol is associated with the lowest risk of diabetes.

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

Even Slow Weight Gain Ups Hypertension, Diabetes, Cancer Risks

After 11 pounds gained, the risk of diabetes went up 31%, hypertension 14%, and cardiovascular disease 8%.

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide Linked With Lower Diabetic Kidney Disease Risk

Liraglutide-treated patients were 22% less likely than placebo recipients to experience a composite outcome of renal events.

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

Visceral to Subcutaneous Fat Ratio Predicts CVD in Diabetes

The addition of V/S ratio to age, eGFR, BNP, antiplatelet agents, and HbA1c significantly improved classification performance for CVD.

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Erectile Dysfunction Afflicts More Than Half of Men With Diabetes

Meta-analysis of studies conducted around the world found that men with diabetes have more than 3.5 times increased risk for erectile dysfunction.

Early Menopause Might Up Type 2 Diabetes

Early Menopause Might Up Type 2 Diabetes

The researchers found that women who experienced premature menopause were 3.7 times more likely to develop diabetes.

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

Canagliflozin Delays Rise in Cardiovascular Biomarkers in Type 2 Diabetes

The cardiac biomarker data provide support for the beneficial cardiovascular effect of sodium glucose co-transporter 2 inhibitors in T2DM.

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Intensive Weight Loss in Diabetes Pts May Increase Frailty Fracture

Diabetes patients pursuing lifestyle interventions had a significantly increased risk of frailty fracture compared to diabetes support and education intervention patients.

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

CDC: More Than 100 Million US Adults Have Diabetes or Prediabetes

Diabetes was seventh leading cause of death in 2015 in United States, according to report.

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Coronary CT Helps Predict CV Events in Type 2 Diabetes

Addition of CCTA-detected obstructive coronary artery disease to risk factors ups prediction of MACE.

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

Insulin Degludec Tied With Fewer Hypoglycemic Episodes

The rates of overall symptomatic hypoglycemia for insulin degludec vs insulin glargine were 185.6 vs 265.4 episodes per 100 PYEs.

Glycemic Control Improves With Hepatitis C Treatment

Glycemic Control Improves With Hepatitis C Treatment

Patients who achieved SVR had a greater drop in HbA1c associated with antiviral treatment than those who sustained treatment failure.

Hospitalizations for Heart Failure Decreasing in US

Hospitalizations for Heart Failure Decreasing in US

Between 2002 and 2013, heart failure hospitalizations declined by 30.8% nationwide, and continue to drop.

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Tx Intensification Delayed in Many T2DM Pts With Elevated HbA1c

Therapeutic inertia was seen in 18.1% of the 12,730 patients with HbA1c of ≥8% at baseline or during follow-up.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Four Risk Factors Account for Most Heart Failure in A-Fib

Four Risk Factors Account for Most Heart Failure in A-Fib

The researchers found that new-onset AF correlated with increased risk of heart failure in multivariable models.

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