Nephrology Conference Coverage Archive
In a study, 42.4% of patients with serum phosphorus of 5.6 to 7 mg/dL lowered their levels to less than 5.5 mg/dL over 2 years.
In a study, patients received half the amount of iron during the reduced dosing period: 126.6 vs 51.2 mg/month.
Individuals with a serum bicarbonate level below 24 mEq/L have a 2-fold increased risk of AKI compared with those with a level of 25-28 mEq/L.
Canagliflozin vs placebo is associated with increased survival and renal outcomes in patients with type 2 diabetes and macroalbuminuria.
Patients who lose 10% or more of their body weight from the time of their listing on a transplant waiting list are at higher risk of death following deceased-donor kidney transplantation.
In a study, progression of calcification did not increase until eGFR falls below 40 mL/min/1.73 m2.
Peritoneal dialysis patients with MCV of 96 fl or more had a 29% greater risk for early death compared with a reference group.
Patients who received hemodialysis 6 times per week instead of 3 showed improvements in biomarkers of mineral metabolism and left ventricular remodeling.
Higher magnesium levels are associated with a lower risk of peripheral artery disease, but only among individuals without impaired renal function.
The objective is to stimulate innovation by industry, academic institutions, and other organizations.
In a Swiss study, patients aged 80 years or more were significantly less likely to die if they had a nephrology referral prior to initiating dialysis.
Patients with vs without anemia prior to starting hemodialysis (HD) were more likely to die despite achieving target hemoglobin levels at month 4 after HD initiation.
Type 2 diabetes is among the leading causes of end-stage renal disease (ESRD), but the estimated cumulative risk of ESRD at 20 years after diagnosis of type 2 diabetes is less than 1%.
Anemia is 66% and 84% more likely to develop among patients in the 3rd and 4th quartiles of serum fibroblast growth factor 23 level vs those in the 1st quartile.
Rates of hyperkalemia associated with receipt of renin-angiotensin-aldosterone system inhibitors vary by age and comorbidities.
The risk of chronic kidney disease among women who experience preeclampsia is particularly elevated within 5 years of delivery.
Longitudinal study with preplanned serum potassium measurements may provide a more accurate estimate of the burden of hyperkalemia among CKD patients.
Patients in the highest quintile of urinary albumin excretion had a 4.5-fold increased risk of urothelial cell carcinoma vs those in quintiles 1-3.
In a phase 2 trial that enrolled 31 patients with autosomal dominant polycystic kidney disease, treatment with bardoxolone resulted in a significant increase in kidney function.
In a study, increases in red blood cell distribution width during the first year of dialysis was associated with greater risks for death.
Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.
Older patients who had more frequent nephrology visits prior to initiating dialysis had a lower incidence of atrial fibrillation in the year after initiating dialysis compared with those who did not.
New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.
Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.
A serum phosphate control target of 4.5 mg/dL or below in hemodialysis patients was accompanied by a decline in fibroblast growth factor 23.
In a prospective study, aspirin users were more likely to have a successful outcome following PTA for venous stenoses in arteriovenous fistulas or grafts.
In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.
Control of parathyroid hormone did not differ markedly at 48 and 72 hours after in-center HD compared with 24 hours after daily oral administration of 30 mg cinacalcet.
Kidney transplant recipients in the highest tertile of serum uromodulin concentration had a 2-fold increased risk of allograft failure compared with those in the lowest tertile.
Among patients on peritoneal dialysis, the odds of death are 32% lower among those with vs without autosomal dominant polycystic kidney disease, meta-analysis finds.
Treatment with a novel urea formulation that is available in the United States safely improves plasma sodium levels, small study shows.
Mean 25-hydroxyvitamin D levels did not differ significantly among groups receiving phosphate binders or dietary therapy.
In a survey, nearly one-third of hemodialysis patients said they disliked fluid restriction.
Study of 109,501 incidental HD patients reveals an association between high mean corpuscular volume and increased risk of all-cause, cardiovascular, and infection-related mortality.
Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.
Researchers found no significant difference between ergocalciferol and cholecalciferol in maintaining levels of vitamin D, parathyroid hormone, and calcium.
Among patients younger than 40, the prevalence of end-stage renal disease secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.
Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.
In a study, the 30-day readmission rate for hemodialysis patients hospitalized for cardiovascular events was 34.2%.
Nearly 86% of diabetic nephropathy patients from an Egyptian outpatient center had elevated iPTH levels.
Phosphate binder use is associated with a 25% and 37% decreased risk of death from infection-related causes and all-causes, respectively, compared with non-users.
Achieving a phosphate value of 1.4 mmol/L seemed optimal.
Intravenous iron and erythropoietin produced a similar hemoglobin response among hemodialysis patients with moderate anemia.
The group targeting higher hemoglobin values experienced less decline in graft function.
Secondary hyperparathyroidism may have a detrimental effect on successful arteriovenous fistula creation, researcher says.
From 2004 to 2012, the incidence of AKI increased from 4.9% to 14.2% among CABG patients and from 2.7% to 8.8% among PCI patients.
HD patients with untreated or ineffectively treated anemia prior to dialysis initiation were more likely to die than those who had consistently well-treated anemia.
In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.
Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.
The 5-year survival rates was 80.7% for patients in the lowest quartile of serum uric acid at HD initiation versus 89.6% for those in the highest quartile.
Among kidney transplant recipients who died with a functioning graft, the cause of death was reported as unknown for 64% of them.
Likelihood of stone formation increases with higher calcium oxalate and calcium phosphate relative supersaturation.
In a pilot study, investigators observed no harmful effects from etelcalcetide injection, and 5 of 10 of patients had a greater than 50% decline in PTH levels.
Study reveals 2-fold higher incidence of bacteremia among dialysis patients with low and high serum sodium levels.
Each 0.1 increase in WHR is associated with a 1.7-fold increased risk of cardiovascular death.
Patients with non-dialysis chronic kidney disease and iron deficiency anemia treated with ferric citrate experienced significant declines in FGF23 regardless of change in serum phosphorus.
Study documents occurrence of rapid correction in 44.3% of hospitalized patients.
Therapy with paricalcitol alone achieved the greatest decline in intact parathyroid hormone among hemodialysis with secondary hyperparathyroidism.
Patients with post-traumatic stress disorder had an 11% lower death risk 1 year after initiating dialysis than those without the disorder, study finds.
Even at very low levels, residual kidney function in hemodialysis patients clears uremic solutes.
Each 1 standard deviation in baseline uric acid levels was associated with a significant 80% increased odds of rapid kidney function decline.
Patients in the lowest quartiles of urinary uromodulin had increased risks of end-stage renal disease and rapid kidney function decline.
In a study, end-stage renal disease was 31% more likely to develop in CKD patients with versus without anemia.
From 1995 to 2015, the prevalence of hypertension and diabetes among patients starting hemodialysis increased from 67.9% to 87.6% and from 43.1% to 59.6%, respectively.
In a study, end-stage renal disease developed in 56% of patients discharged from a hospital with acute kidney injury requiring dialysis.
High levels of parathyroid hormone and fibroblast growth factor 23 in CKD patients are associated with need for renal replacement therapy or a 50% or greater decline in eGFR.
After adjusting for confounders, patients on intensive home hemodialysis and recipients of deceased-donor kidneys showed no significant difference in death risk
Timing of AKI after urgent percutaneous coronary intervention affects risk of significant kidney function loss 1 year after the procedure.
CKD patients in the 3rd and 4th quartiles of c-terminal serum fibroblast growth factor 23 had a 74% and 73% higher risk for anemia compared with those in the 1st quartile.
US veterans who underwent coronary artery bypass grafting versus percutaneous coronary intervention prior to starting dialysis had a 28% lower risk of death.
Intact parathyroid hormone levels decline in proportion with SHPT severity in patients taking the drug.
Proteinuria and renin-angiotensin-aldosterone system inhibitors are independently associated with a significant 6-fold increased odds for anemia in patients with diabetic nephropathy.
Study of U.S. veterans found that patients with resistant hypertension had 23%, 31%, and 144% higher risk of myocardial infarction, stroke, and end-stage renal disease, respectively.
In a study 383 kidney transplant recipients, low levels of 25-hydroxyvitamin D were not associated with an increased risk of graft loss following transplantation.
Admission serum phosphorus levels below 2.5 and 4.9 mg/dL and above are associated with increased odds of dying in the hospital.
Girls with end-stage renal disease had 35% greater risk for death than boys.
After switching to sucroferric oxyhydroxide, a higher proportion of patients achieved in-range serum phosphorus levels.
Recurrent, but not first-time, symptomatic kidney stone formers are at elevated risk for end-stage renal disease and death.
Hemodialysis patients who have fistula are 24% more likely to experience a first infection-related hospitalization if they dialyze at home rather than in a dialysis center.
Findings from 4454 studies are being presented at the world's premier nephrology conference.
In a study, obese transplant recipients with low muscle mass had an increased risk of death but not graft loss.
The incidence of NODAT was 33.8% among patients who switched to everolimus and 36.4% among those who stayed on calcineurin inhibitors.
Opportunistic viral and fungal infections or malignancies develop in 34% of kidney transplant recipients, but these complications do not affect patient or graft survival.
Highest level of opioid use in the year prior to transplantation was associated with a 45% and 28% increased risk of death and graft loss, respectively.
In a study, diabetes in both the donor and recipient was associated with triple the risk of death at 5 years post-transplant compared with the absence of diabetes in both the donor and recipient.
Post-transplant UTI rates were lower when cephalexin was added to SMX-TMP than when SMX-TMP was used alone (7.5% vs 25.8%), study finds.
Kidney transplant recipients who experienced an episode of bacteremia had double the risks of graft failure and death.
Older patients with a Charlson Comorbidity Index score below 5 had a higher 3-year survival rate than those with a score of 5 or higher (90% vs 76%).
High-KDPI kidneys can improve the likelihood of a functioning graft compared with waiting for a superior kidney.
Venous thromboembolism is associated with a 4.1-fold increased risk of death and a 2.3-fold increased risk of death-censored graft loss among kidney transplant recipients.
Risk factors include impaired renal function and inadequate hydration prior to contrast exposure.
Angioplasty plus stenting is associated with less residual stenosis and a lower restenosis rate compared with angioplasty alone.
Researchers report that matching deceased kidney donors and kidney recipients by cytomegalovirus serostatus optimizes high- and low-risk profiles.
Five-year graft survival rates among recipients of kidneys from living donors increased from 76.6% in 1985-1894 to 85.4% in 2009-2015.
The adjusted 5-year risk of insulin use following donation is 5 times higher among obese vs normal weight donors.
In a study of renal transplant patients who received ureteral stents, ciprofloxacin did not lower the incidence of UTI compared with SMX-TMP.
As 25(OH)D levels increased, systolic blood pressure decreased significantly, even after accounting for calcium intake.
In a phase 2b trial, around half of patients taking the novel calcineurin inhibitor at a dose of 23.7 mg twice daily achieved complete remission at 48 weeks.
A patient experienced painful skin ulcers despite having normal renal function.
In a study, vonapanitase did not improve primary patency compared with placebo, but did improve secondary patency and fistula use for hemodialysis.
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)