CKD

Hepatitis C Infection May Hasten Chronic Kidney Disease Progression

Hepatitis C Infection May Hasten Chronic Kidney Disease Progression

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Patients with both CKD and hepatitis C virus infection are at nearly 2-fold higher risk of end-stage renal disease with those who have CKD only.

Statin Use in Advanced CKD Lowers Death Risk

Statin Use in Advanced CKD Lowers Death Risk

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Researchers report a significant 41% decreased mortality risk among patients with advanced CKD who used statins compared with those who did not.

Low eGFR, Worsening Renal Function Predict Higher Post-PCI Death Risk

Low eGFR, Worsening Renal Function Predict Higher Post-PCI Death Risk

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Low eGFR and worsening renal function are independently associated with a nearly 3-fold increased mortality risk among patients undergoing percutaneous coronary intervention.

CKD Patients Use Proton Pump Inhibitors Longer

CKD Patients Use Proton Pump Inhibitors Longer

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Researchers find that physicians prescribe much longer courses of PPI therapy to patients with vs without CKD, despite the potential nephrotoxic effects.

Higher Caffeine Intake May Decrease Death Risk in CKD

Higher Caffeine Intake May Decrease Death Risk in CKD

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Among individuals with chronic kidney disease, those in the top quartile of daily caffeine consumption had a 25% lower risk of death vs those in the bottom quartile.

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

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Japanese post-marketing study identified no new safety concerns among patients with non-dialysis chronic kidney disease treated with darbepoetin alfa and followed up for 3 years.

Gastrointestinal Lesions Common in Patients With CKD Anemia

Gastrointestinal Lesions Common in Patients With CKD Anemia

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In a Spanish study, endoscopic evaluation of patients with CKD and anemia revealed that 68.2% of patients had at least 1 gastrointestinal lesion.

Febuxostat May Preserve Renal Function in Some CKD Subgroups

Febuxostat May Preserve Renal Function in Some CKD Subgroups

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Study of patients with CKD stage 3 and asymptomatic hyperuricemia showed that febuoxostat ameliorated the annual decline in eGFR vs placebo in those without proteinuria.

CKD Progression Linked to Sodium Chloride Level

CKD Progression Linked to Sodium Chloride Level

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Low serum sodium chloride concentrations are associated with an increased risk of renal function decline events, especially among patients with CKD stage G4 and anemic patients.

Accuracy of 24-Hour Urine Phosphorus Challenged

Accuracy of 24-Hour Urine Phosphorus Challenged

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A new study found that 24-hour urine phosphorus is inversely related to whole-body retention, but is not related to net intestinal absorption.

Acute Renal Failure in CKD Patients Less Likely With PCI

Acute Renal Failure in CKD Patients Less Likely With PCI

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In a study, percutaneous coronary intervention was associated with a 72% decreased risk of acute renal failure compared with coronary artery bypass grafting in patients with chronic kidney disease.

Vitamin D Stores Lower in the Obese, Overweight

Vitamin D Stores Lower in the Obese, Overweight

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Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.

Correcting Metabolic Acidosis May Preserve Muscle Mass

Correcting Metabolic Acidosis May Preserve Muscle Mass

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Oral sodium bicarbonate treatment was associated with improved lean body mass and kidney function in patients with metabolic acidosis due to CKD stages 3 and 4.

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

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A single 30-gram oral dose of sodium polystyrene sulfonate resulted in a significant decrease in serum potassium within 24 hours.

CKD Prevalence, Progression Rate High Among Elderly Diabetics

CKD Prevalence, Progression Rate High Among Elderly Diabetics

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In a South Korean study, nearly 60% of elderly patients with type 2 diabetes had chronic kidney disease at baseline.

FGF23 Predicts Development of CKD Anemia

FGF23 Predicts Development of CKD Anemia

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Anemia is 66% and 84% more likely to develop among patients in the 3rd and 4th quartiles of serum fibroblast growth factor 23 level vs those in the 1st quartile.

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

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Rates of hyperkalemia associated with receipt of renin-angiotensin-aldosterone system inhibitors vary by age and comorbidities.

Hyperkalemia Common in Stages 2-5 CKD

Hyperkalemia Common in Stages 2-5 CKD

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Longitudinal study with preplanned serum potassium measurements may provide a more accurate estimate of the burden of hyperkalemia among CKD patients.

Tolvaptan Cleared in US for ADPKD in Adults

Tolvaptan Cleared in US for ADPKD in Adults

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Originally approved for hyponatremia, the medication is the first FDA-approved treatment for rapidly progressing autosomal dominant polycystic kidney disease in adults.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

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Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

No Reduction in Platelets Found With IV Iron Use in CKD

No Reduction in Platelets Found With IV Iron Use in CKD

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New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.

Fenofibrate Therapy Slows CKD Progression in Diabetics

Fenofibrate Therapy Slows CKD Progression in Diabetics

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In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

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Among patients on peritoneal dialysis, the odds of death are 32% lower among those with vs without autosomal dominant polycystic kidney disease, meta-analysis finds.

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

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Study of 109,501 incidental HD patients reveals an association between high mean corpuscular volume and increased risk of all-cause, cardiovascular, and infection-related mortality.

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

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Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

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Among patients younger than 40, the prevalence of end-stage renal disease secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

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In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

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Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

GFR Decline Tied to Protein Intake in Diabetic Blacks

GFR Decline Tied to Protein Intake in Diabetic Blacks

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The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

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Pulmonary hypertension in patients with any degree of renal insufficiency is associated with elevated risks of cardiovascular events and death.

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