Chronic Kidney Disease

Midstream Urine Microbiome Diverse in Seniors With CKD

Midstream Urine Microbiome Diverse in Seniors With CKD

After adjustment for demographics and diabetes status, microbiome diversity linked to estimated GFR.

Increasing Water Intake Does Not Slow eGFR Decline in CKD

Increasing Water Intake Does Not Slow eGFR Decline in CKD

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A nonsignificant 0.3 mL/min/1.73 m2 difference in eGFR was found between the usual and increased water intake groups after 1 year.

Coaching to improve water intake does not improve kidney function in adults with chronic kidney disease

1. In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease. 2. Increasing fluid intake via coaching was adequate to lower vasopressin secretion in patients. Evidence Rating Level: 1 (Excellent) Study Rundown: In both preclinical animal models and clinical human studies, increased water []

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

Sleep Duration Tied With Quality of Life in CKD

Sleep Duration Tied With Quality of Life in CKD

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Patients with chronic kidney disease who sleep 7 hours a night have the highest health-related quality of life, new study finds.

Tolvaptan Cleared in US for ADPKD in Adults

Tolvaptan Cleared in US for ADPKD in Adults

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Originally approved for hyponatremia, the medication is the first FDA-approved treatment for rapidly progressing autosomal dominant polycystic kidney disease in adults.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

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Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

No Reduction in Platelets Found With IV Iron Use in CKD

No Reduction in Platelets Found With IV Iron Use in CKD

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New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.

Fenofibrate Therapy Slows CKD Progression in Diabetics

Fenofibrate Therapy Slows CKD Progression in Diabetics

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In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

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Among patients on peritoneal dialysis, the odds of death are 32% lower among those with vs without autosomal dominant polycystic kidney disease, meta-analysis finds.

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

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Study of 109,501 incidental HD patients reveals an association between high mean corpuscular volume and increased risk of all-cause, cardiovascular, and infection-related mortality.

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

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Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

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Among patients younger than 40, the prevalence of end-stage renal disease secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

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In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.

Factors Limiting CKD Screening Among Black Patients

Factors Limiting CKD Screening Among Black Patients

However, culturally sensitive education, engagement can up community screening

Calcitriol Found Not to Improve Hepcidin Levels in CKD

Calcitriol Found Not to Improve Hepcidin Levels in CKD

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In a trial, oral calcitriol of 0.5 mcg daily did not reduce hepcidin levels in patients with stage 3 to 4 CKD.

CKD Patients Burdened With Symptoms at End of Life

CKD Patients Burdened With Symptoms at End of Life

Findings based on a small study tracking patients with chronic kidney disease in the last year of life

Marijuana Use Not Tied to Kidney Function

Marijuana Use Not Tied to Kidney Function

Researchers compared current and past marijuana use to never users.

World Kidney Day 2018 Focuses on Women and Kidney Diseases

World Kidney Day 2018 Focuses on Women and Kidney Diseases

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Women face unique challenges to their kidney health, including during pregnancy, according to a new report.

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

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Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

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Vitamin D levels increased from 13.2 to 33.7 ng/mL in nondialysis CKD patients treated with 50,000 units of cholecalciferol weekly for 12 weeks.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

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In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

GFR Decline Tied to Protein Intake in Diabetic Blacks

GFR Decline Tied to Protein Intake in Diabetic Blacks

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The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.

Children With CKD Have Lower IQs

Children With CKD Have Lower IQs

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One possible explanation is that increased plasma levels of uremic solutes resulting from kidney disease may impair synaptic development.

Copeptin Predicts Kidney Diseases

Copeptin Predicts Kidney Diseases

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Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.

Anticoagulants Tied With Stroke, Hemorrhage in CKD

Anticoagulants Tied With Stroke, Hemorrhage in CKD

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Study questions the efficacy and safety of prescribing anticoagulants to older patients with atrial fibrillation and nondialysis chronic kidney disease.

Coronary Artery Calcification Risk Factors in CKD Identified

Coronary Artery Calcification Risk Factors in CKD Identified

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Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.

ICD placement in CKD patients increases hospitalizations without survival benefit

1. Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality. 2. However, ICD placement in patients with CKD was associated with increased risk of heart failure-related and any-cause hospitalization. Evidence Rating Level: 2 (Good) []

Kidney Failure Rate Varies by Glomerulonephropathy Type

Kidney Failure Rate Varies by Glomerulonephropathy Type

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End-stage renal disease was 3.4 times more likely to develop among patients with immunoglobulin A nephropathy compared with those who had minimal change disease, study finds.

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

Risk scores summarizing 8 diseases, markers tied to cancer risk in dose-response manner

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