Bilateral Oophorectomy Increases CKD Risk in Premenopausal Women

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Premenopausal women who undergo bilateral oophorectomy are at 42% higher risk of chronic kidney disease, a study found.
Premenopausal women who undergo bilateral oophorectomy are at 42% higher risk of chronic kidney disease, a study found.

Bilateral oophorectomy in premenopausal women, especially those aged 45 years or younger, is associated with an increased risk of chronic kidney disease (CKD), new study findings suggest.

The study is the first to explore the long-term risk of CKD in women undergoing bilateral oophorectomy, according to investigators Walter A. Rocca, MD, and collaborators at Mayo Clinic in Rochester, Minnesota.

Their population-based cohort study included 1653 women living in Olmsted County, Minnesota who underwent bilateral oophorectomy prior to age 50 years and before onset of menopause from 1988 to 2007. Dr Rocco's team matched these women by age with a reference group of 1653 women who did not undergo oophorectomy. The women had a median age of women in both groups was 44 years. The median follow-up was 14 years.

Compared with the reference group, the women who underwent oophorectomy had a significant adjusted 42% increased risk of CKD, Dr Rocca's team reported online in the Clinical Journal of the American Society of Nephrology. Women who underwent oophorectomy at age 45 years or younger had a significant adjusted 59% increased risk of CKD.

The investigators primarily defined CKD as an estimated glomerular filtration rate below 60 mL/min/1.73 m2 on 2 occasions more than 90 days apart.

The authors concluded that women considering bilateral oophorectomy to prevent ovarian cancer, especially women aged 45 years or younger, need to be counseled regarding the potential risks of multiple morbidities, which may include the risk of CKD.

Of the 1653 women in the oophorectomy group, 1024 (63%) and 614 (37%) underwent the procedure at age 45 years or younger and 46 to 49 years, respectively.

Reference

Kattah AG, Smith CY, Rocca LG, et al. CKD in patients with bilateral oophorectomy. Clin J Am Soc Nephrol. 2018; published online ahead of print.

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