Cystatin C Tied to Cumulative Hearing Impairment

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Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.
Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

(HealthDay News) -- Reduced kidney function, estimated using cystatin C, is associated with 20-year cumulative incidence of hearing impairment (HI), according to a study published online in JAMA Otolaryngology-Head & Neck Surgery.

Carla R. Schubert, from the University of Wisconsin in Madison, and colleagues obtained data from the Epidemiology of Hearing Loss Study to examine the correlation between cystatin C (as a biomarker and a marker of kidney function) and 20-year incidence of HI. Data were included for 863 participants aged 48 to 86 years with cystatin C data and no HI at baseline.

The researchers found that cystatin C was associated with increased risk of developing HI in models adjusted for age and sex (hazard ratio, 1.20; 95% confidence interval [CI], 1.07 to 1.34 per 0.2-mg/L increase in cystatin C concentration). After further adjustments, including those for education level and current smoking, the correlation was attenuated (hazard ratio, 1.11; 95% CI, 0.98 to 1.27 per 0.2-mg/L increase in cystatin C concentration). Cystatin C was used to determine low estimated glomerular filtration rate in both the age- and sex-adjusted model as well as in the multivariable-adjusted model and was significantly associated with the 20-year cumulative incidence of HI (hazard ratios, 1.70 [95% CI, 1.16 to 2.48] and 1.50 [95% CI, 1.02 to 2.22] for <60 to ≥60 mL/min/1.73 m², respectively).

"Reduced kidney function as estimated using cystatin C, but not cystatin C alone, was associated with the 20-year cumulative incidence of HI," the authors write.

References

Schubert CR, Paulsen AJ, Nondahl DM, et al. Association Between Cystatin C and 20-Year Cumulative Incidence of Hearing Impairment in the Epidemiology of Hearing Loss Study. JAMA Otolaryngol Head Neck Surg. Published online April 26, 2018. doi:10.1001/jamaoto.2018.0041

Monsell EM. Extending the Ear-Kidney Association to Presbycusis. JAMA Otolaryngol Head Neck Surg. Published online April 26, 2018. doi:10.1001/jamaoto.2018.0275

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