Chronic Kidney Disease (CKD) News Archive
Atrial fibrillation may up stroke risk as much as 1.5 to 2 times in CKD patients, according to study findings.
DOAC users with eGFRs less than 60 mL/min/1.73m2 had a 23% higher risk for bleeding than warfarin users.
VFI approach for direct measurement of glomerular filtration rate is accurate and reproducible.
Decline in rates of cardiac stress testing in Medicare beneficiaries aged 66 years from 2008 to 2012.
Even patients with mild chronic kidney disease were prevented from participating in clinical trials of drugs for bladder, breast, colorectal, lung, and prostate cancers.
Drinking one cup of coffee daily was associated with 24% lower risk for chronic kidney disease.
Individuals with higher blood lead levels experienced greater decreases in eGFR.
In a South Korean study, nearly 60% of elderly patients with type 2 diabetes had chronic kidney disease at baseline.
Persistent cocaine use by patients with chronic kidney disease more than doubled their risk for death.
Anemia is 66% and 84% more likely to develop among patients in the 3rd and 4th quartiles of serum fibroblast growth factor 23 level vs those in the 1st quartile.
Rates of hyperkalemia associated with receipt of renin-angiotensin-aldosterone system inhibitors vary by age and comorbidities.
The risk of chronic kidney disease among women who experience preeclampsia is particularly elevated within 5 years of delivery.
Longitudinal study with preplanned serum potassium measurements may provide a more accurate estimate of the burden of hyperkalemia among CKD patients.
In a phase 2 trial that enrolled 31 patients with autosomal dominant polycystic kidney disease, treatment with bardoxolone resulted in a significant increase in kidney function.
After adjustment for demographics and diabetes status, microbiome diversity linked to estimated GFR.
A nonsignificant 0.3 mL/min/1.73 m2 difference in eGFR was found between the usual and increased water intake groups after 1 year.
Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.
Patients with chronic kidney disease who sleep 7 hours a night have the highest health-related quality of life, new study finds.
Originally approved for hyponatremia, the medication is the first FDA-approved treatment for rapidly progressing autosomal dominant polycystic kidney disease in adults.
Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.
New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.
In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.
Among patients on peritoneal dialysis, the odds of death are 32% lower among those with vs without autosomal dominant polycystic kidney disease, meta-analysis finds.
Study of 109,501 incidental HD patients reveals an association between high mean corpuscular volume and increased risk of all-cause, cardiovascular, and infection-related mortality.
Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.
Among patients younger than 40, the prevalence of end-stage renal disease secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.
In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.
However, culturally sensitive education, engagement can up community screening
In a trial, oral calcitriol of 0.5 mcg daily did not reduce hepcidin levels in patients with stage 3 to 4 CKD.
Findings based on a small study tracking patients with chronic kidney disease in the last year of life
Researchers compared current and past marijuana use to never users.
Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.
Vitamin D levels increased from 13.2 to 33.7 ng/mL in nondialysis CKD patients treated with 50,000 units of cholecalciferol weekly for 12 weeks.
In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.
The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.
One possible explanation is that increased plasma levels of uremic solutes resulting from kidney disease may impair synaptic development.
Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.
Study questions the efficacy and safety of prescribing anticoagulants to older patients with atrial fibrillation and nondialysis chronic kidney disease.
Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.
Pulmonary hypertension in patients with any degree of renal insufficiency is associated with elevated risks of cardiovascular events and death.
End-stage renal disease was 3.4 times more likely to develop among patients with immunoglobulin A nephropathy compared with those who had minimal change disease, study finds.
Risk scores summarizing 8 diseases, markers tied to cancer risk in dose-response manner
Study finds no difference in all-cause mortality among patients with chronic kidney disease and heart failure who received implantable cardioverter defibrillators and those who did not.
In an Israeli study, individuals who had any type of kidney disease as children had a 4-fold increased risk of end-stage renal disease in adulthood.
At 1 and 7 years after bariatric surgery, 63% and 53% of patients at moderate risk for chronic kidney disease before surgery had an improvement in their CKD risk category.
Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.
Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.
Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.
Pretreating enteral nutrition formula with sodium polystyrene sulfonate lowers potassium levels in hyperkalemic children with chronic kidney disease, small study finds.
CKD occurrence was seen in 3.4% of HIV patients receiving the combination of medications.
Antiretroviral therapies have prolonged the survival of HIV patients, but the drugs can have adverse effects on the kidneys.
In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.
Urinary ceruloplamin has potential to be a chronic kidney disease biomarker for patients with sickle cell anemia.
A fourth of adults with CKD of unknown cause, familial nephropathy, or hypertension have diagnosed mutations that can be identified using WES.
Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.
In a study, taking a medication not on a nephrologists' list, not taking a specified medication, taking different doses, or following a different frequency topped the list.
In the subcohorts of patients with a diagnosis of bipolar disorder, continuing lithium was associated with decreased end-stage CKD, whereas continuing anticonvulsants was not.
The model was based on 6 variables readily obtained at hospital discharge.
Fibrillary glomerulonephritis glomeruli exhibit overexpression of DNAJB9 protein.
No improvement for patients with MDD and chronic kidney disease without dialysis dependence.
Risk for both chronic kidney disease, end-stage renal disease higher with proton pump inhibitor use.
Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.
Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.
Transcatheter aortic valve replacement increases the risk of requiring renal replacement therapy and the risk of death among patients with stage 4 or 5 CKD.
Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism
Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.
Uromodulin may be a novel predictive serum biomarker.
In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.
Study finds link between particulate matter and renal function.
Among hemodialysis patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for the condition.
Short and poor quality sleep are unrecognized risk factors for CKD progression.
Tinnitus is 3-fold more likely to develop in patients with versus without chronic kidney disease, new study shows.
Targeting and treating systolic blood pressure to a lower range was associated with a 14% decreased risk of death, meta-analysis shows.
Targeting a systolic blood pressure below 120 mm Hg versus 135 to 139 mm Hg increased the absolute risk of incident CKD by 2.6% over 3 years, but decreased the risk of cardiovascular events or death.
Older age, Indian ethnicity, hypertension, chronic kidney disease, creatinine level, glomerular filtration rate, and history of stroke were associated with prevalent retinal emboli in multivariable-adjusted analysis.
In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.
No significant association found between marijuana use and change in estimated glomerular filtration rate or development of albuminuria.
Bosutinib treatment was associated with a 66% decrease in the annual rate of kidney enlargement.
Lower respiratory tract infections, urinary tract infections, and sepsis made up a larger proportion of infections as kidney function worsened.
Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.
International survey finds geographic variation in the subtype frequencies in biopsied patients.
Atrial fibrillation risk increases as estimated glomerular filtration rate decreases and albuminuria increases, according to a new meta-analysis.
Pilot study suggests intranasal theophylline may be worth further investigation as a treatment.
The researchers found that serious events occurred in 14.7% and 3.2% of participants in the methylprednisolone and placebo groups, respectively, mainly due to excess serious infections.
The investigators assessed proteomic profiling of 80 proteins using a multiplex assay.
After adjustment for age, gender, albumin levels, atrial fibrillation, and renal transplantation, LV GLS ≤10.6% was significantly associated with increased risk of all-cause mortality.
Researchers used pulse wave analysis to measure subendocardial viability ratio, a measure of myocardial perfusion, and its association with hemoglobin.
The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.
CKD patients treated to a target systolic blood pressure of less than 120 mm Hg were 28% less likely to die early.
Anemic patients were 41% and 80% more likely to have coronary artery disease and peripheral artery disease than non-anemic patients.
Chronic kidney disease stage 3 is 23% more likely to develop in individuals in the highest versus lowest quintile of consumption of red and processed meat.
The researchers said rising rates of diabetes and hypertension may help explain the increase in kidney disease, along with several other factors.
Most elderly CKD patients ultimately will not require or desire renal replacement therapy.
Study findings suggest that the medication may offer renal protection.
In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.
Gd-IgA1 level may represent a useful biomarker for risk stratification.
The incorrect dose was associated with a higher risk of major bleeding but no significant difference in stroke prevention, the researchers said.
GI bleeding was predicted by absence of PPI therapy, CKD, COPD, history of peptic ulcer disease, and liver cirrhosis.
Overall, patients receiving TRF-budesonide saw a 24.4% reduction in their average urine protein creatinine ratio over 9 months.
Coffee drinkers did not have a statistically significant difference in kidney size or estimated glomerular filtration rate compared with those who did not drink coffee.
Renal and Urology News Articles
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)