Chronic Kidney Disease (CKD) News Archive

CKD Patients Burdened With Symptoms at End of Life

CKD Patients Burdened With Symptoms at End of Life

Findings based on a small study tracking patients with chronic kidney disease in the last year of life

Marijuana Use Not Tied to Kidney Function

Marijuana Use Not Tied to Kidney Function

Researchers compared current and past marijuana use to never users.

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

Vitamin D levels increased from 13.2 to 33.7 ng/mL in nondialysis CKD patients treated with 50,000 units of cholecalciferol weekly for 12 weeks.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

GFR Decline Tied to Protein Intake in Diabetic Blacks

GFR Decline Tied to Protein Intake in Diabetic Blacks

The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.

Children With CKD Have Lower IQs

Children With CKD Have Lower IQs

One possible explanation is that increased plasma levels of uremic solutes resulting from kidney disease may impair synaptic development.

Copeptin Predicts Kidney Diseases

Copeptin Predicts Kidney Diseases

Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.

Anticoagulants Tied With Stroke, Hemorrhage in CKD

Anticoagulants Tied With Stroke, Hemorrhage in CKD

Study questions the efficacy and safety of prescribing anticoagulants to older patients with atrial fibrillation and nondialysis chronic kidney disease.

Coronary Artery Calcification Risk Factors in CKD Identified

Coronary Artery Calcification Risk Factors in CKD Identified

Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary hypertension in patients with any degree of renal insufficiency is associated with elevated risks of cardiovascular events and death.

Kidney Failure Rate Varies by Glomerulonephropathy Type

Kidney Failure Rate Varies by Glomerulonephropathy Type

End-stage renal disease was 3.4 times more likely to develop among patients with immunoglobulin A nephropathy compared with those who had minimal change disease, study finds.

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

Risk scores summarizing 8 diseases, markers tied to cancer risk in dose-response manner

CKD Patients With Heart Failure May Not Benefit From ICDs

CKD Patients With Heart Failure May Not Benefit From ICDs

Study finds no difference in all-cause mortality among patients with chronic kidney disease and heart failure who received implantable cardioverter defibrillators and those who did not.

Childhood Kidney Disease Ups Risk for Kidney Failure Later in Life

Childhood Kidney Disease Ups Risk for Kidney Failure Later in Life

In an Israeli study, individuals who had any type of kidney disease as children had a 4-fold increased risk of end-stage renal disease in adulthood.

Kidney Disease Risk May Be Reduced With Bariatric Surgery

Kidney Disease Risk May Be Reduced With Bariatric Surgery

At 1 and 7 years after bariatric surgery, 63% and 53% of patients at moderate risk for chronic kidney disease before surgery had an improvement in their CKD risk category.

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

Total Kidney Volume in ADPKD Predicts CKD Progression

Total Kidney Volume in ADPKD Predicts CKD Progression

Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.

Some High-risk Heart Failure Patients Benefit From MRAs

Some High-risk Heart Failure Patients Benefit From MRAs

Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

Pretreating enteral nutrition formula with sodium polystyrene sulfonate lowers potassium levels in hyperkalemic children with chronic kidney disease, small study finds.

Antiretroviral Combo May Increase Kidney Disease Risk

Antiretroviral Combo May Increase Kidney Disease Risk

CKD occurrence was seen in 3.4% of HIV patients receiving the combination of medications.

Shift in HIV-Associated Kidney Disease Characterized

Shift in HIV-Associated Kidney Disease Characterized

Antiretroviral therapies have prolonged the survival of HIV patients, but the drugs can have adverse effects on the kidneys.

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Urinary ceruloplamin has potential to be a chronic kidney disease biomarker for patients with sickle cell anemia.

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

A fourth of adults with CKD of unknown cause, familial nephropathy, or hypertension have diagnosed mutations that can be identified using WES.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Medication Discrepancies Common in Advanced CKD

Medication Discrepancies Common in Advanced CKD

In a study, taking a medication not on a nephrologists' list, not taking a specified medication, taking different doses, or following a different frequency topped the list.

Lithium Therapy May Not Increase ESRD Risk

Lithium Therapy May Not Increase ESRD Risk

In the subcohorts of patients with a diagnosis of bipolar disorder, continuing lithium was associated with decreased end-stage CKD, whereas continuing anticonvulsants was not.

New Model Improves Predictions of Advanced CKD Following AKI

New Model Improves Predictions of Advanced CKD Following AKI

The model was based on 6 variables readily obtained at hospital discharge.

Potential Target for Fibrillary Glomerulonephritis ID'd

Potential Target for Fibrillary Glomerulonephritis ID'd

Fibrillary glomerulonephritis glomeruli exhibit overexpression of DNAJB9 protein.

Sertraline Not Effective for Depression in CKD

Sertraline Not Effective for Depression in CKD

No improvement for patients with MDD and chronic kidney disease without dialysis dependence.

Proton Pump Inhibitor Use May Up CKD, ESRD

Proton Pump Inhibitor Use May Up CKD, ESRD

Risk for both chronic kidney disease, end-stage renal disease higher with proton pump inhibitor use.

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

Transcatheter aortic valve replacement increases the risk of requiring renal replacement therapy and the risk of death among patients with stage 4 or 5 CKD.

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Serum Uromodulin May Predict CKD Development

Serum Uromodulin May Predict CKD Development

Uromodulin may be a novel predictive serum biomarker.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Air Pollution May Lead to CKD, ESRD

Air Pollution May Lead to CKD, ESRD

Study finds link between particulate matter and renal function.

Pruritus in Hemodialysis Patients Underestimated, Undertreated

Pruritus in Hemodialysis Patients Underestimated, Undertreated

Among hemodialysis patients always or nearly always bothered by itchy skin, 17% did not report their symptoms to a health care provider and 18% used no treatment for the condition.

Sleep Duration, Quality Associated With CKD Progression

Sleep Duration, Quality Associated With CKD Progression

Short and poor quality sleep are unrecognized risk factors for CKD progression.

Chronic Kidney Disease Raises Tinnitus Risk

Chronic Kidney Disease Raises Tinnitus Risk

Tinnitus is 3-fold more likely to develop in patients with versus without chronic kidney disease, new study shows.

Intensive BP Control May Reduce Death Risk in CKD Patients

Intensive BP Control May Reduce Death Risk in CKD Patients

Targeting and treating systolic blood pressure to a lower range was associated with a 14% decreased risk of death, meta-analysis shows.

Chronic Kidney Disease Risk Higher With Intensive BP Control

Chronic Kidney Disease Risk Higher With Intensive BP Control

Targeting a systolic blood pressure below 120 mm Hg versus 135 to 139 mm Hg increased the absolute risk of incident CKD by 2.6% over 3 years, but decreased the risk of cardiovascular events or death.

Retinal Emboli Associated With CVD Risk Factors, Stroke, CKD

Retinal Emboli Associated With CVD Risk Factors, Stroke, CKD

Older age, Indian ethnicity, hypertension, chronic kidney disease, creatinine level, glomerular filtration rate, and history of stroke were associated with prevalent retinal emboli in multivariable-adjusted analysis.

Metoprolol Increases Uric Acid, Risk of Gout

Metoprolol Increases Uric Acid, Risk of Gout

In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.

Study Finds No Link Between Marijuana Use and Kidney Function

Study Finds No Link Between Marijuana Use and Kidney Function

No significant association found between marijuana use and change in estimated glomerular filtration rate or development of albuminuria.

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

Cancer Drug Slows ADPKD Cyst Growth, Study Finds

Bosutinib treatment was associated with a 66% decrease in the annual rate of kidney enlargement.

Infection Risk Increases as Kidney Function Declines

Infection Risk Increases as Kidney Function Declines

Lower respiratory tract infections, urinary tract infections, and sepsis made up a larger proportion of infections as kidney function worsened.

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.

Glomerular Disease Differs Globally

Glomerular Disease Differs Globally

International survey finds geographic variation in the subtype frequencies in biopsied patients.

Decreasing Kidney Function Increases Atrial Fibrillation Risk

Decreasing Kidney Function Increases Atrial Fibrillation Risk

Atrial fibrillation risk increases as estimated glomerular filtration rate decreases and albuminuria increases, according to a new meta-analysis.

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

Olfactory Deficits, Malnutrition Markers Linked in CKD, ESRD Patients

Pilot study suggests intranasal theophylline may be worth further investigation as a treatment.

Methylprednisolone Tied With Serious Adverse Events in IgA Nephropathy

Methylprednisolone Tied With Serious Adverse Events in IgA Nephropathy

The researchers found that serious events occurred in 14.7% and 3.2% of participants in the methylprednisolone and placebo groups, respectively, mainly due to excess serious infections.

Proteomics Identifies CKD Predictors

Proteomics Identifies CKD Predictors

The investigators assessed proteomic profiling of 80 proteins using a multiplex assay.

Increased Mortality in CKD Pts With Impaired LV Global Longitudinal Strain

Increased Mortality in CKD Pts With Impaired LV Global Longitudinal Strain

After adjustment for age, gender, albumin levels, atrial fibrillation, and renal transplantation, LV GLS ≤10.6% was significantly associated with increased risk of all-cause mortality.

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Researchers used pulse wave analysis to measure subendocardial viability ratio, a measure of myocardial perfusion, and its association with hemoglobin.

suPAR May Trigger CKD, Renal Decline in APOL1 Variant Pts

suPAR May Trigger CKD, Renal Decline in APOL1 Variant Pts

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with 2 copies of APOL1 gene variants.

Intensive Blood Pressure Reduction Benefits CKD Patients

Intensive Blood Pressure Reduction Benefits CKD Patients

CKD patients treated to a target systolic blood pressure of less than 120 mm Hg were 28% less likely to die early.

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Anemic patients were 41% and 80% more likely to have coronary artery disease and peripheral artery disease than non-anemic patients.

CKD Linked to High Intake of Red, Processed Meat

CKD Linked to High Intake of Red, Processed Meat

Chronic kidney disease stage 3 is 23% more likely to develop in individuals in the highest versus lowest quintile of consumption of red and processed meat.

1 in 7 Americans Has CKD and Most Unaware

1 in 7 Americans Has CKD and Most Unaware

The researchers said rising rates of diabetes and hypertension may help explain the increase in kidney disease, along with several other factors.

Nephrology Referrals May Not Benefit Elderly CKD Patients

Nephrology Referrals May Not Benefit Elderly CKD Patients

Most elderly CKD patients ultimately will not require or desire renal replacement therapy.

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Canagliflozin Lowers Cardiovascular Risks in Type 2 Diabetes Patients

Study findings suggest that the medication may offer renal protection.

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

High-Dose Vitamin D May Halt Secondary Hyperparathyroidism Progression

In a study of CKD patients, intact PTH levels remained stable those receiving cholecalciferol 8000 IU daily but increased in placebo recipients.

Biomarker May Identify High-risk IgAN Patients

Biomarker May Identify High-risk IgAN Patients

Gd-IgA1 level may represent a useful biomarker for risk stratification.

Afib Patients With CKD on NOACs May Be Overdosed

Afib Patients With CKD on NOACs May Be Overdosed

The incorrect dose was associated with a higher risk of major bleeding but no significant difference in stroke prevention, the researchers said.

Model Predicts Acute GI Bleeding With Oral Anticoagulant Tx

Model Predicts Acute GI Bleeding With Oral Anticoagulant Tx

GI bleeding was predicted by absence of PPI therapy, CKD, COPD, history of peptic ulcer disease, and liver cirrhosis.

Novel Enteric Budesonide Reduces Proteinuria in IgAN

Novel Enteric Budesonide Reduces Proteinuria in IgAN

Overall, patients receiving TRF-budesonide saw a 24.4% reduction in their average urine protein creatinine ratio over 9 months.

Coffee Consumption Does Not Worsen ADPKD

Coffee Consumption Does Not Worsen ADPKD

Coffee drinkers did not have a statistically significant difference in kidney size or estimated glomerular filtration rate compared with those who did not drink coffee.

New Review Highlights Iron Deficiency Anemia in CKD

New Review Highlights Iron Deficiency Anemia in CKD

Intravenous iron should be strongly considered for patients treated with ESAs or hemodialysis, according to reviewers.

Anthropometric Body Fat Measurements Can Estimate Renal Function Decline

Anthropometric Body Fat Measurements Can Estimate Renal Function Decline

The researchers found that 17% of the population experienced KF decline, while incident CKD occurred in 17% of those at risk.

Hospital-Acquired Complications Can Be Deadly for CKD Patients

Hospital-Acquired Complications Can Be Deadly for CKD Patients

Preventable HACs are associated with higher mortality, incremental LOS, and greater risk of readmission, especially in people with CKD.

Testosterone Replacement May Delay CKD Progression

Testosterone Replacement May Delay CKD Progression

Study demonstrates decreased risk of end-stage renal disease and all-cause mortality.

Anemia Burden in Chronic Kidney Disease Described

Anemia Burden in Chronic Kidney Disease Described

The prevalence of low hemoglobin levels increases with declining renal function.

Reduced Kidney Function a Major Cause of Cardiovascular Deaths

Reduced Kidney Function a Major Cause of Cardiovascular Deaths

Reduced glomerular filtration rate ranked similarly to high total cholesterol as a risk factor for disability-adjusted life years.

Tolvaptan Offers Sustained Slowing of Renal Function Decline in ADPKD

Tolvaptan Offers Sustained Slowing of Renal Function Decline in ADPKD

Open-label extension study confirms disease-modifying effect on eGFR, but not total kidney volume growth.

AKI Predictors in PE Patients Identified

AKI Predictors in PE Patients Identified

Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.

Intensive BP Control Does Not Prevent CKD Progression

Intensive BP Control Does Not Prevent CKD Progression

Blood pressure targets below 130/80 and below 140/90 mm Hg are associated with similar renal outcomes among non-diabetics, meta-analysis shows.

Diabetes Increases Poor Outcomes in Heart Failure Patients

Diabetes Increases Poor Outcomes in Heart Failure Patients

Patients with diabetes had higher cumulative rates of 1-year all-cause death, CVD death, and HF hospitalization.

Dietary Potassium Lowers CVD, CKD Risks, Regardless of Sodium

Dietary Potassium Lowers CVD, CKD Risks, Regardless of Sodium

Numerous population studies demonstrate a relationship between higher dietary K+ and lower blood pressure regardless of sodium intake.

Chronic Kidney Disease More Likely in PPI Users

Chronic Kidney Disease More Likely in PPI Users

Proton pump inhibitors need not first cause acute kidney injury for CKD risk to be elevated.

Low Salt Diet Improves Blood Pressure in CKD

Low Salt Diet Improves Blood Pressure in CKD

With dietitian counseling, limiting sodium to 2000 mg per daily is feasible for chronic kidney disease patients.

More Patients Hospitalized for Atrial Fibrillation

More Patients Hospitalized for Atrial Fibrillation

Adjusted rates of hospitalization for AF increased by almost 1% per year between 1999 and 2013.

CKD Patients Satisfied With Nurse-Led Care

CKD Patients Satisfied With Nurse-Led Care

In an era of person-centered care, it is important to measure patient satisfaction using appropriate and standardized questionnaires.

Skin Sodium Linked to LVH in CKD Patients

Skin Sodium Linked to LVH in CKD Patients

Skin sodium content related more strongly to left ventricular mass than treated blood pressure.

Red Blood Cell Size Linked With Mortality in CKD Patients

Red Blood Cell Size Linked With Mortality in CKD Patients

CKD patients with larger erythrocyte volumes had more than triple the risk of dying from cardiovascular causes, researchers reported.

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Patients with an eGFR below 60 mL/min/1.73 m2 were more likely to die in the hospital or be discharged to hospice.

Non-Dialysis CKD Patients Have High Out-of-Pocket Expenses

Non-Dialysis CKD Patients Have High Out-of-Pocket Expenses

Chronic kidney disease patients spent $760 more out of pocket for health care than patients free of CKD, stroke, or cancer.

Aortic Calcification in CKD Patients Linked to Nutrition

Aortic Calcification in CKD Patients Linked to Nutrition

The median aortic calcification index (ACI) decreased significantly with increasing geriatric nutritional risk index tertile.

Statins May Slow CKD Progression

Statins May Slow CKD Progression

Statin use was associated with a significant decrease in all-cause mortality risk.

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

Biomarkers, Clinical Variables Predict Renal Function Loss in T2DM

A small set of serum protein biomarkers combined with clinical variables, enhances the prediction of renal function loss over a wide range of baseline eGFR values.

Higher Systolic BP Target Recommended for Older Patients

Higher Systolic BP Target Recommended for Older Patients

New guidelines suggest aiming for a systolic pressure less than 150 mm Hg in hypertensive individuals aged 60 or older.

Metformin Linked With Lower Mortality, Better Outcomes in CKD

Metformin Linked With Lower Mortality, Better Outcomes in CKD

Metformin is associated with reduced all-cause mortality in patients with CKD, CHF, or CLD with hepatic impairment.

CKD Patients May Live Longer on a Plant-Based Diet

CKD Patients May Live Longer on a Plant-Based Diet

Kidney disease patients who regularly consumed produce, legumes, cereals, whole grains, and fiber had a 27% lower risk of death compared with those who did not.

Pre-dialysis CKD Is a Risk Factor for Serious Infection

Pre-dialysis CKD Is a Risk Factor for Serious Infection

Lower eGFR and higher ACR are associated with an elevated risk of infection-related hospitalization and infection-related death.

Novel Biomarker Can Predict Kidney Damage in Type 2 Diabetes

Novel Biomarker Can Predict Kidney Damage in Type 2 Diabetes

Urine haptoglobin, is a novel biomarker and complement to urine albumin for predicting kidney damage in patients with type 2 diabetes.

Using a Multidisciplinary Team Cost-Effective in CKD

Using a Multidisciplinary Team Cost-Effective in CKD

Multidisciplinary care program alleviates the much larger cost of dialysis.

Sodium Reduction May Improve Albuminuria in Nondiabetic CKD

Sodium Reduction May Improve Albuminuria in Nondiabetic CKD

Reducing sodium consumption to about 2,500 mg daily was associated with albuminuria improvement.

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