Chronic Kidney Disease (CKD) News Archive

New Cholesterol Guidelines Consider CKD 'Risk-Enhancing'

New Cholesterol Guidelines Consider CKD 'Risk-Enhancing'

In their 2018 cholesterol guidelines, the American Heart Association and American College of Cardiology recommend individualized risk and treatment options.

Allopurinol Linked to Reduced Risk for CKD Stage 3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol use is not associated with renal function decline among those with newly diagnosed gout.

Novel Acid-Binding Drug Effective for Metabolic Acidosis in CKD

Novel Acid-Binding Drug Effective for Metabolic Acidosis in CKD

A polymer that binds to hydrochloric acid in the GI tract and does not enter the systemic circulation significantly improved serum bicarbonate levels compared with placebo.

High FGF23 Increases Fall Risk in CKD

High FGF23 Increases Fall Risk in CKD

Highest vs lowest quartile of intact fibroblast growth factor 23 is associated with a 2-fold greater risk of a first fall in older patients.

High Uric Acid Raises Death Risk in CKD

High Uric Acid Raises Death Risk in CKD

Patients with chronic kidney disease who have hyperuricemia have a 3-fold higher risk of all-cause mortality.

Marijuana Use by CKD Patients May Hasten Renal Function Decline

Marijuana Use by CKD Patients May Hasten Renal Function Decline

Marijuana users with chronic kidney disease experienced a significantly greater annual decline in estimated glomerular filtration rate than non-users, study finds.

Intensive SBP Tx Cuts Kidney Damage Biomarkers in Incident CKD

Intensive SBP Tx Cuts Kidney Damage Biomarkers in Incident CKD

Incident CKD accompanied by decreases in kidney damage biomarkers in setting of intensive treatment.

Poor Experience With PCP Linked to Hospitalization in CKD

Poor Experience With PCP Linked to Hospitalization in CKD

Risk of hospitalization up for Hispanic patients with lower scores on Ambulatory Care Experiences Survey

Payment Reform Urged To Encourage Chronic Kidney Disease Care

Payment Reform Urged To Encourage Chronic Kidney Disease Care

Authors of a recent editorial contend that federal reimbursement polices discourage delivery of the complex care needed by patients with chronic kidney disease who are not on dialysis.

Inflammatory Marker Tied to Decline in Kidney Function

Inflammatory Marker Tied to Decline in Kidney Function

Soluble tumor necrosis factor receptor-1 tied to decline in multiethnic cohort

PCI, CABG Both Acceptable for CKD Patients With LMCAD

PCI, CABG Both Acceptable for CKD Patients With LMCAD

Patients with, without chronic kidney disease have less acute renal failure with PCI.

Kidney Function Decline in General Population Linked to Low Calcium

Kidney Function Decline in General Population Linked to Low Calcium

Association found in a Japanese study of individuals in the general population who did not have chronic kidney disease.

Enlarged Kidneys in Neonates With Congenital Heart Disease

Enlarged Kidneys in Neonates With Congenital Heart Disease

Kidneys of neonates with left heart obstruction consistently found to be larger than normal

Hepatitis C Infection May Hasten Chronic Kidney Disease Progression

Hepatitis C Infection May Hasten Chronic Kidney Disease Progression

Patients with both CKD and hepatitis C virus infection are at nearly 2-fold higher risk of end-stage renal disease with those who have CKD only.

CKD Associated With Increased Inter-Arm BP Difference

CKD Associated With Increased Inter-Arm BP Difference

Increased inter-arm difference in systolic blood pressure independently predicts development of chronic kidney disease in the general population, a new study suggests.

Bilateral Oophorectomy Increases CKD Risk in Premenopausal Women

Bilateral Oophorectomy Increases CKD Risk in Premenopausal Women

The increased risk of chronic kidney disease is more pronounced among women who undergo the procedure at age 45 years or younger.

Statin Use in Advanced CKD Lowers Death Risk

Statin Use in Advanced CKD Lowers Death Risk

Researchers report a significant 41% decreased mortality risk among patients with advanced CKD who used statins compared with those who did not.

Low eGFR, Worsening Renal Function Predict Higher Post-PCI Death Risk

Low eGFR, Worsening Renal Function Predict Higher Post-PCI Death Risk

Low eGFR and worsening renal function are independently associated with a nearly 3-fold increased mortality risk among patients undergoing percutaneous coronary intervention.

CKD Patients Use Proton Pump Inhibitors Longer

CKD Patients Use Proton Pump Inhibitors Longer

Researchers find that physicians prescribe much longer courses of PPI therapy to patients with vs without CKD, despite the potential nephrotoxic effects.

Higher Caffeine Intake May Decrease Death Risk in CKD

Higher Caffeine Intake May Decrease Death Risk in CKD

Among individuals with chronic kidney disease, those in the top quartile of daily caffeine consumption had a 25% lower risk of death vs those in the bottom quartile.

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

Study: Long-Term Darbepoetin Use Safe, Effective in Non-Dialysis CKD

Japanese post-marketing study identified no new safety concerns among patients with non-dialysis chronic kidney disease treated with darbepoetin alfa and followed up for 3 years.

Gastrointestinal Lesions Common in Patients With CKD Anemia

Gastrointestinal Lesions Common in Patients With CKD Anemia

In a Spanish study, endoscopic evaluation of patients with CKD and anemia revealed that 68.2% of patients had at least 1 gastrointestinal lesion.

Diabetes Develops At a Higher Rate in the CKD Population

Diabetes Develops At a Higher Rate in the CKD Population

New study reveals a type 2 diabetes incidence rate of 17.81 cases per 1000 person-years, a rate much higher than in the general population.

Febuxostat May Preserve Renal Function in Some CKD Subgroups

Febuxostat May Preserve Renal Function in Some CKD Subgroups

Study of patients with CKD stage 3 and asymptomatic hyperuricemia showed that febuoxostat ameliorated the annual decline in eGFR vs placebo in those without proteinuria.

CKD Progression Linked to Sodium Chloride Level

CKD Progression Linked to Sodium Chloride Level

Low serum sodium chloride concentrations are associated with an increased risk of renal function decline events, especially among patients with CKD stage G4 and anemic patients.

Report: CKD Does Not Preclude Plant-Based Diets

Report: CKD Does Not Preclude Plant-Based Diets

Concerns about nutritional deficiency in CKD patients are unfounded, and plant-based diets may actually be good for them, the authors of a new report contend.

Accuracy of 24-Hour Urine Phosphorus Challenged

Accuracy of 24-Hour Urine Phosphorus Challenged

A new study found that 24-hour urine phosphorus is inversely related to whole-body retention, but is not related to net intestinal absorption.

Acute Renal Failure in CKD Patients Less Likely With PCI

Acute Renal Failure in CKD Patients Less Likely With PCI

In a study, percutaneous coronary intervention was associated with a 72% decreased risk of acute renal failure compared with coronary artery bypass grafting in patients with chronic kidney disease.

Vitamin D Stores Lower in the Obese, Overweight

Vitamin D Stores Lower in the Obese, Overweight

Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.

Correcting Metabolic Acidosis May Preserve Muscle Mass

Correcting Metabolic Acidosis May Preserve Muscle Mass

Oral sodium bicarbonate treatment was associated with improved lean body mass and kidney function in patients with metabolic acidosis due to CKD stages 3 and 4.

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

Single-Dose Potassium-Lowering Drug Effective in CKD, ESRD

A single 30-gram oral dose of sodium polystyrene sulfonate resulted in a significant decrease in serum potassium within 24 hours.

Stroke, Death Risk Increase With CKD and AFib

Stroke, Death Risk Increase With CKD and AFib

Atrial fibrillation may up stroke risk as much as 1.5 to 2 times in CKD patients, according to study findings.

DOACs Increase Bleeding Risk More Than Warfarin in CKD

DOACs Increase Bleeding Risk More Than Warfarin in CKD

DOAC users with eGFRs less than 60 mL/min/1.73m2 had a 23% higher risk for bleeding than warfarin users.

New Technique Allows Rapid Bedside Measurement of GFR

New Technique Allows Rapid Bedside Measurement of GFR

VFI approach for direct measurement of glomerular filtration rate is accurate and reproducible.

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Decline in rates of cardiac stress testing in Medicare beneficiaries aged 66 years from 2008 to 2012.

CKD Patients Often Excluded From Cancer Trials

CKD Patients Often Excluded From Cancer Trials

Even patients with mild chronic kidney disease were prevented from participating in clinical trials of drugs for bladder, breast, colorectal, lung, and prostate cancers.

Daily Coffee Drinking May Prevent CKD

Daily Coffee Drinking May Prevent CKD

Drinking one cup of coffee daily was associated with 24% lower risk for chronic kidney disease.

Low-Level Lead Exposure Found to Increase CKD Risk

Low-Level Lead Exposure Found to Increase CKD Risk

Individuals with higher blood lead levels experienced greater decreases in eGFR.

CKD Prevalence, Progression Rate High Among Elderly Diabetics

CKD Prevalence, Progression Rate High Among Elderly Diabetics

In a South Korean study, nearly 60% of elderly patients with type 2 diabetes had chronic kidney disease at baseline.

Substance Use Ups Risks for CKD Progression, Mortality

Substance Use Ups Risks for CKD Progression, Mortality

Persistent cocaine use by patients with chronic kidney disease more than doubled their risk for death.

FGF23 Predicts Development of CKD Anemia

FGF23 Predicts Development of CKD Anemia

Anemia is 66% and 84% more likely to develop among patients in the 3rd and 4th quartiles of serum fibroblast growth factor 23 level vs those in the 1st quartile.

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

Studies Provide Detailed Look at Treatment-Related Hyperkalemia

Rates of hyperkalemia associated with receipt of renin-angiotensin-aldosterone system inhibitors vary by age and comorbidities.

Preeclampsia Increases Kidney Disease Risk Post-Pregnancy

Preeclampsia Increases Kidney Disease Risk Post-Pregnancy

The risk of chronic kidney disease among women who experience preeclampsia is particularly elevated within 5 years of delivery.

Hyperkalemia Common in Stages 2-5 CKD

Hyperkalemia Common in Stages 2-5 CKD

Longitudinal study with preplanned serum potassium measurements may provide a more accurate estimate of the burden of hyperkalemia among CKD patients.

Bardoxolone Shows Promise for ADPKD

Bardoxolone Shows Promise for ADPKD

In a phase 2 trial that enrolled 31 patients with autosomal dominant polycystic kidney disease, treatment with bardoxolone resulted in a significant increase in kidney function.

Midstream Urine Microbiome Diverse in Seniors With CKD

Midstream Urine Microbiome Diverse in Seniors With CKD

After adjustment for demographics and diabetes status, microbiome diversity linked to estimated GFR.

Increasing Water Intake Does Not Slow eGFR Decline in CKD

Increasing Water Intake Does Not Slow eGFR Decline in CKD

A nonsignificant 0.3 mL/min/1.73 m2 difference in eGFR was found between the usual and increased water intake groups after 1 year.

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C Tied to Cumulative Hearing Impairment

Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.

Sleep Duration Tied With Quality of Life in CKD

Sleep Duration Tied With Quality of Life in CKD

Patients with chronic kidney disease who sleep 7 hours a night have the highest health-related quality of life, new study finds.

Tolvaptan Cleared in US for ADPKD in Adults

Tolvaptan Cleared in US for ADPKD in Adults

Originally approved for hyponatremia, the medication is the first FDA-approved treatment for rapidly progressing autosomal dominant polycystic kidney disease in adults.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

No Reduction in Platelets Found With IV Iron Use in CKD

No Reduction in Platelets Found With IV Iron Use in CKD

New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.

Fenofibrate Therapy Slows CKD Progression in Diabetics

Fenofibrate Therapy Slows CKD Progression in Diabetics

In a study of patients with type 2 diabetes, researchers observed a significantly lower annual decline in estimated glomerular filtration rate among those treated with fenofibrates vs placebo.

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

ADPKD Linked to Lower Mortality in Peritoneal Dialysis Patients

Among patients on peritoneal dialysis, the odds of death are 32% lower among those with vs without autosomal dominant polycystic kidney disease, meta-analysis finds.

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

High Mean Corpuscular Volume Ups Hemodialysis Patient Death Risk

Study of 109,501 incidental HD patients reveals an association between high mean corpuscular volume and increased risk of all-cause, cardiovascular, and infection-related mortality.

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

Among patients younger than 40, the prevalence of end-stage renal disease secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

Outpatient AKI Is a Risk Factor for Death, Adverse Renal Outcomes

In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.

Factors Limiting CKD Screening Among Black Patients

Factors Limiting CKD Screening Among Black Patients

However, culturally sensitive education, engagement can up community screening

Calcitriol Found Not to Improve Hepcidin Levels in CKD

Calcitriol Found Not to Improve Hepcidin Levels in CKD

In a trial, oral calcitriol of 0.5 mcg daily did not reduce hepcidin levels in patients with stage 3 to 4 CKD.

CKD Patients Burdened With Symptoms at End of Life

CKD Patients Burdened With Symptoms at End of Life

Findings based on a small study tracking patients with chronic kidney disease in the last year of life

Marijuana Use Not Tied to Kidney Function

Marijuana Use Not Tied to Kidney Function

Researchers compared current and past marijuana use to never users.

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

Vitamin D Supplementation Improves Endothelial Dysfunction in CKD

Vitamin D levels increased from 13.2 to 33.7 ng/mL in nondialysis CKD patients treated with 50,000 units of cholecalciferol weekly for 12 weeks.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

GFR Decline Tied to Protein Intake in Diabetic Blacks

GFR Decline Tied to Protein Intake in Diabetic Blacks

The percentage decline in estimated glomerular filtration rate over an 8-year period was greater among those with vs without diabetes across all quintiles of protein intake.

Children With CKD Have Lower IQs

Children With CKD Have Lower IQs

One possible explanation is that increased plasma levels of uremic solutes resulting from kidney disease may impair synaptic development.

Copeptin Predicts Kidney Diseases

Copeptin Predicts Kidney Diseases

Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.

Anticoagulants Tied With Stroke, Hemorrhage in CKD

Anticoagulants Tied With Stroke, Hemorrhage in CKD

Study questions the efficacy and safety of prescribing anticoagulants to older patients with atrial fibrillation and nondialysis chronic kidney disease.

Coronary Artery Calcification Risk Factors in CKD Identified

Coronary Artery Calcification Risk Factors in CKD Identified

Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary hypertension in patients with any degree of renal insufficiency is associated with elevated risks of cardiovascular events and death.

Kidney Failure Rate Varies by Glomerulonephropathy Type

Kidney Failure Rate Varies by Glomerulonephropathy Type

End-stage renal disease was 3.4 times more likely to develop among patients with immunoglobulin A nephropathy compared with those who had minimal change disease, study finds.

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

CKD, Diabetes, CVD, and More Boost Risks for Cancer, Mortality

Risk scores summarizing 8 diseases, markers tied to cancer risk in dose-response manner

CKD Patients With Heart Failure May Not Benefit From ICDs

CKD Patients With Heart Failure May Not Benefit From ICDs

Study finds no difference in all-cause mortality among patients with chronic kidney disease and heart failure who received implantable cardioverter defibrillators and those who did not.

Childhood Kidney Disease Ups Risk for Kidney Failure Later in Life

Childhood Kidney Disease Ups Risk for Kidney Failure Later in Life

In an Israeli study, individuals who had any type of kidney disease as children had a 4-fold increased risk of end-stage renal disease in adulthood.

Kidney Disease Risk May Be Reduced With Bariatric Surgery

Kidney Disease Risk May Be Reduced With Bariatric Surgery

At 1 and 7 years after bariatric surgery, 63% and 53% of patients at moderate risk for chronic kidney disease before surgery had an improvement in their CKD risk category.

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

Total Kidney Volume in ADPKD Predicts CKD Progression

Total Kidney Volume in ADPKD Predicts CKD Progression

Each 100 mL/m increment in baseline height-adjusted total kidney volume is associated with 38% and 42% greater odds of developing stage 3 and 4 chronic kidney disease, respectively.

Some High-risk Heart Failure Patients Benefit From MRAs

Some High-risk Heart Failure Patients Benefit From MRAs

Mineralocorticoid receptor antagonists found to lower hospital readmission risk in patients with heart failure and concomitant diabetes or renal insufficiency.

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

Pretreating Enteral Nutrition Effective for Pediatric Hyperkalemia

Pretreating enteral nutrition formula with sodium polystyrene sulfonate lowers potassium levels in hyperkalemic children with chronic kidney disease, small study finds.

Antiretroviral Combo May Increase Kidney Disease Risk

Antiretroviral Combo May Increase Kidney Disease Risk

CKD occurrence was seen in 3.4% of HIV patients receiving the combination of medications.

Shift in HIV-Associated Kidney Disease Characterized

Shift in HIV-Associated Kidney Disease Characterized

Antiretroviral therapies have prolonged the survival of HIV patients, but the drugs can have adverse effects on the kidneys.

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Urinary ceruloplamin has potential to be a chronic kidney disease biomarker for patients with sickle cell anemia.

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

Whole-exome Sequencing Aids Diagnosis of CKD of Unknown Cause

A fourth of adults with CKD of unknown cause, familial nephropathy, or hypertension have diagnosed mutations that can be identified using WES.

Diabetic CKD Patients Survive Longer With Metformin

Diabetic CKD Patients Survive Longer With Metformin

Diabetic patients with chronic kidney disease starting treatment with metformin have a 36% decreased risk of death compared with those starting on a sulfonylurea, study finds.

Medication Discrepancies Common in Advanced CKD

Medication Discrepancies Common in Advanced CKD

In a study, taking a medication not on a nephrologists' list, not taking a specified medication, taking different doses, or following a different frequency topped the list.

Lithium Therapy May Not Increase ESRD Risk

Lithium Therapy May Not Increase ESRD Risk

In the subcohorts of patients with a diagnosis of bipolar disorder, continuing lithium was associated with decreased end-stage CKD, whereas continuing anticonvulsants was not.

New Model Improves Predictions of Advanced CKD Following AKI

New Model Improves Predictions of Advanced CKD Following AKI

The model was based on 6 variables readily obtained at hospital discharge.

Potential Target for Fibrillary Glomerulonephritis ID'd

Potential Target for Fibrillary Glomerulonephritis ID'd

Fibrillary glomerulonephritis glomeruli exhibit overexpression of DNAJB9 protein.

Sertraline Not Effective for Depression in CKD

Sertraline Not Effective for Depression in CKD

No improvement for patients with MDD and chronic kidney disease without dialysis dependence.

Proton Pump Inhibitor Use May Up CKD, ESRD

Proton Pump Inhibitor Use May Up CKD, ESRD

Risk for both chronic kidney disease, end-stage renal disease higher with proton pump inhibitor use.

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Tolvaptan Slows Renal Function Decline in Later-Stage ADPKD

Patients with autosomal dominant polycystic kidney disease treated with tolvaptan experienced a 35% decrease in the annual rate of decline in eGFR.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

TAVR Ups Risk of ESRD, Death for Advanced CKD Patients

Transcatheter aortic valve replacement increases the risk of requiring renal replacement therapy and the risk of death among patients with stage 4 or 5 CKD.

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Bleeding, Death Similar for DOAC vs Warfarin in VTE

Direct oral anticoagulants not linked to increased risk of major bleeding, death in venous thromboembolism

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Drug Combo Promising for HCV Infection in Patients With Advanced CKD

Researchers report a high rate of sustained virologic response after 12 weeks of treatment with a ribavirin-free co-formulation of glecaprevir and pibrentasvir.

Serum Uromodulin May Predict CKD Development

Serum Uromodulin May Predict CKD Development

Uromodulin may be a novel predictive serum biomarker.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Air Pollution May Lead to CKD, ESRD

Air Pollution May Lead to CKD, ESRD

Study finds link between particulate matter and renal function.

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