Genetic Hyperglycemia Ups CAD Risk, Apart From T2DM
Hyperglycemia from genetics increases the risk of coronary artery disease separately from type 2 diabetes and other CAD risk factors.
(HealthDay News) — Genetic predisposition to hyperglycemia raises the odds of coronary artery disease (CAD), independent of type 2 diabetes and other CAD risk factors, according to research published online in Diabetes Care.
Jordi Merino, PhD, from Massachusetts General Hospital in Boston, and colleagues conducted a discovery and validation genetic instrumental analysis to test the hypothesis that of all the potential metabolic contributors to type 2 diabetes and its metabolic consequences, genetically driven hyperglycemia alone has an effect on CAD risk. Analysis relied upon summary-level statistics from the largest published meta-analyses of genome-wide association studies for fasting glucose (FG; 133,010 participants free of diabetes) and CAD (63,746 case subjects and 130,681 control subjects).
The researchers found that using an instrumental variable analysis of 12 FG-raising variants, a 1 mmol/L increase in FG revealed an effect-size estimate of 1.43 CAD odds (95% confidence interval, 1.14 to 1.79). After excluding variants for heterogeneity and pleiotropic effects on other CAD risk factors, the association remained (odds ratio, 1.33; 95% confidence interval, 1.02 to 1.73). The 12 FG-increasing variants did not significantly increase type 2 diabetes risk (odds ratio, 1.05; 95% confidence interval, 0.91 to 1.23), and its prevalence was constant across FG genetic risk score quintiles (P =.72).
"These findings suggest that modulating glycemia may provide cardiovascular benefit," the authors write.
- Merino J, Leong A, Posner DC, et al. Genetically Driven Hyperglycemia Increases Risk of Coronary Artery Disease Separately From Type 2 Diabetes. Diabetes Care. 15 March 2017. doi: 10.2337/dc16-2625