Lead Exposure May Increase Risk for Cardiovascular Disease Mortality

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Environmental lead exposure tied to all-cause, cardiovascular disease, ischemic heart disease mortality.
Environmental lead exposure tied to all-cause, cardiovascular disease, ischemic heart disease mortality.

(HealthDay News) -- Environmental lead exposure is a risk factor for all-cause, cardiovascular disease, and ischemic heart disease mortality, according to a study published online in The Lancet Public Health.

Bruce P. Lanphear, MD, from Simon Fraser University in Vancouver, Canada, and colleagues quantified the relative contribution of environmental lead exposure to all-cause mortality, cardiovascular disease mortality, and ischemic heart disease mortality in a nationally representative sample of 14,289 adults aged 20 years and older enrolled in the Third National Health and Nutrition Examination Survey.

The researchers found that 20% of participants had a concentration of lead of at least 5 µg/dL in blood. A total of 4422 people died during a median follow-up of 19.3 years: 38% from cardiovascular disease and 22% from ischemic heart disease. There was a correlation for an increase in the concentration of lead in blood from 1.0 to 6.7 µg/dL (10th to 90th percentiles) with all-cause mortality, cardiovascular disease mortality, and ischemic heart disease mortality (hazard ratios, 1.37, 1.70, and 2.08, respectively). The population attributable fractions of the concentration of lead in blood for all-cause, cardiovascular, and ischemic heart disease mortality were 18.0, 28.7, and 37.4%, respectively, equivalent to 412,000, 256,000, and 185,000 deaths annually.

"A comprehensive strategy to prevent deaths from cardiovascular disease should include efforts to reduce lead exposure," the authors write.

One author disclosed serving as an expert witness in plaintiff cases of childhood lead poisoning.

References

Lanphear BP, Rauch S, Auinger P, Allen RW, Hornung RW. Low-level lead exposure and mortality in US adults: a population-based cohort study. Lancet. doi:10.1016/S2468-2667(18)30025-2

Landrigan PJ. Lead and the heart: an ancient metal's contribution to modern disease. Lancet. DOI: 10.1016/S2468-2667(18)30043-4

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