Bladder Cancer

Blue Light Cystoscopy Enhances Detection of Cancerous Bladder Lesions

Blue Light Cystoscopy Enhances Detection of Cancerous Bladder Lesions

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Real-world study confirms the improved sensitivity of blue light vs white light cystoscopy (91% vs 79%) for detecting bladder cancer.

Neoadjuvant Chemo vs TUR Before RC Ups Survival

Neoadjuvant Chemo vs TUR Before RC Ups Survival

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Study findings suggest that clinicians should use neoadjuvant chemotherapy in many more muscle-invasive bladder cancer patients.

Neoadjuvant vs Adjuvant Chemo Ups MIBC Patient Survival

Neoadjuvant vs Adjuvant Chemo Ups MIBC Patient Survival

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The 5-year overall survival rate is significantly higher among radical cystectomy patients who receive neoadjuvant vs adjuvant chemotherapy, study finds.

Aspirin Use Prior to Radical Cystectomy Linked to Improved Survival

Aspirin Use Prior to Radical Cystectomy Linked to Improved Survival

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Daily use of aspirin before radical cystectomy is associated with a significant 36% and 30% decreased risk of cancer-specific and all-cause mortality.

Bladder Cancer, UTUC More Common in Kidney Transplant Recipients

Bladder Cancer, UTUC More Common in Kidney Transplant Recipients

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A study found that bladder cancer and UTUC occurred in 122.22 and 113.97 per 100,000 persons per year, respectively, among kidney transplant recipients.

UroVysion Results Predict Post-BCG Bladder Cancer Outcomes

UroVysion Results Predict Post-BCG Bladder Cancer Outcomes

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Positive results before BCG treatment and at the 6-week instillation are associated with an increased likelihood of disease recurrence and/or progression.

Predictors of Post-cystectomy C. difficile Infection Identified

Predictors of Post-cystectomy C. difficile Infection Identified

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Female sex and need for a blood transfusion are associated with development of Clostridium difficile infection following radical cystectomy.

Radical Cystectomy for MIBC Offers Better Survival vs Chemoradiation

Radical Cystectomy for MIBC Offers Better Survival vs Chemoradiation

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Large study reveals a significant 15% survival advantage associated with radical cystectomy vs chemoradiation therapy.

Developments in the Management of BCG-Unresponsive NMIBC

Developments in the Management of BCG-Unresponsive NMIBC

Novel immunotherapies and chemotherapies hold promise as non-surgical salvage options.

PPD Skin Test Enhances BCG Therapy in Bladder Cancer

PPD Skin Test Enhances BCG Therapy in Bladder Cancer

Enhanced therapeutic effect of bacillus Calmette-Gurin tx in non-muscle invasive bladder cancer.

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

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Men and women who smoke are at 2.3-fold and 2.7-fold increased risk of bladder cancer compared with non-smokers.

Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

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Instilling gemcitabine into the bladder immediately following resection of low-grade non-muscle-invasive bladder cancer significantly lowers recurrence risk.

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

One-year overall survival of 61% for gemcitabine and cisplatin plus ipilimumab.

Non-Invasive Test for Urothelial Cancer Detection

Non-Invasive Test for Urothelial Cancer Detection

When combined with cytology, UroSEEK detected 95% of patients who developed bladder cancer

Bladder Cancer Mortality in Men Lower With 5-ARI Use

Bladder Cancer Mortality in Men Lower With 5-ARI Use

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Use of 5-alpha-reductase inhibitors before and after diagnosis of the malignancy is associated with a 15% and 22% decreased risk of bladder cancer mortality, respectively.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

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In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model, based on 6 factors, predicts overall survival for patients treated with atezolizumab

Active Surveillance Reasonable for NMIBC

Active Surveillance Reasonable for NMIBC

Appears to be a cost-effective strategy for patients with small size, stage pTa or pT1a recurrent tumors

Atezolizumab Safe, Beneficial Long-Term in mUC

Atezolizumab Safe, Beneficial Long-Term in mUC

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In a 3-year study, toxic effects of atezolizumab remained manageable and responses durable.

Biopsy, Pathology Results Often Differ in UTUC

Biopsy, Pathology Results Often Differ in UTUC

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Study results serve as a caution against relying on ureteroscopic biopsy to establish tumor grade and stage, researchers say.

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

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Patients with bladder adenocarcinomas have the best survival, whereas those with small cell carcinomas of the bladder have the worst.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

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In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

Nicotine and nicotine-derived nitrosamine ketone enhance mutational susceptibility in human cells.

Post-Cystectomy UTI Risk Linked to Comorbidities

Post-Cystectomy UTI Risk Linked to Comorbidities

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A Charlson Comorbidity Index score of 2 or higher is an independent risk factor for urinary tract infections within 90 days following radical cystectomy for bladder cancer, study finds.

MRI Differentiates Low-Grade Bladder Tumors

MRI Differentiates Low-Grade Bladder Tumors

Diffusion-weighted imaging and use of higher field strengths further improve accuracy.

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

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The locoregional recurrence-free survival rate at 2 years was significantly higher for patients treated with chemotherapy plus RT versus those treated with chemotherapy alone.

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

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Patients on hemodialysis who undergo radical cystectomy for bladder cancer have 30-day and 5-year mortality rates of 9.3% and 87.9%, respectively, study finds.

Bladder Cancer Risk Higher in Urinary Stone Formers

Bladder Cancer Risk Higher in Urinary Stone Formers

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Patients with versus without a history of urinary calculi had nearly 2-fold greater odds of bladder cancer, meta-analysis showed.

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

40% of active surveillance events were deemed to require treatment.

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

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Chemoradiation for muscle-invasive bladder cancer is associated with a lower 1-year mortality risk versus radical cystectomy, but at year 2 and beyond, mortality risk is lower with radical cystectomy.

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