Female Sex Ups Radical Cystectomy Surgical Site Infection Risk

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Among patients undergoing radical cystectomy, female sex is independently associated with a 21% increased odds of surgical site infections compared with male sex.
Among patients undergoing radical cystectomy, female sex is independently associated with a 21% increased odds of surgical site infections compared with male sex.

Female patients who undergo radical cystectomy (RC) have a higher risk of surgical site infection (SSI) than male patients who undergo the surgery, according to a new Canadian study published online ahead of print in Urologic Oncology.

In a historical cohort study involving 9275 RC patients, a team led by Rodney H. Breau, MD, of the Ottawa Hospital Research Institute in Ottawa, Ontario, found that, on multivariable analysis, female sex was independently associated with significant 21% increased odds of SSI compared with male sex.

The investigators identified patients using the American College of Surgeons' National Surgical Quality Improvement Program database (2006 to 2016). SSI occurred in 1277 (13.7%) patients: 308 female patients (16.4%) and 969 male patients (13.1%).

Significantly greater proportions of female than male patients experienced superficial infections (8% vs 5.5%). The investigators found no significant difference in the proportions of female and male patients who experienced deep infections (2.1% vs 1.5%) and organ/abdominal space infections (6.2% vs 6%).

Women who experienced SSI had a significantly greater risk of other complications, including wound dehiscence, septic shock, and need for reoperation, Dr Breau and his colleagues reported.

Reference

Abdi H, Elzayat E, Cagiannos I, et al. Female radical cystectomy patients have a higher risk of surgical site infections. Urol Oncol. 2018; published online ahead of print.

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