Bladder Cancer News Archive

PPD Skin Test Enhances BCG Therapy in Bladder Cancer

PPD Skin Test Enhances BCG Therapy in Bladder Cancer

Enhanced therapeutic effect of bacillus Calmette-Gurin tx in non-muscle invasive bladder cancer.

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Men and women who smoke are at 2.3-fold and 2.7-fold increased risk of bladder cancer compared with non-smokers.

Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

Instilling gemcitabine into the bladder immediately following resection of low-grade non-muscle-invasive bladder cancer significantly lowers recurrence risk.

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

One-year overall survival of 61% for gemcitabine and cisplatin plus ipilimumab.

Non-Invasive Test for Urothelial Cancer Detection

Non-Invasive Test for Urothelial Cancer Detection

When combined with cytology, UroSEEK detected 95% of patients who developed bladder cancer

Bladder Cancer Mortality in Men Lower With 5-ARI Use

Bladder Cancer Mortality in Men Lower With 5-ARI Use

Use of 5-alpha-reductase inhibitors before and after diagnosis of the malignancy is associated with a 15% and 22% decreased risk of bladder cancer mortality, respectively.

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

Advanced CKD Linked to Worse Radical Cystectomy Outcomes

In multivariable analyses, CKD stage G3b or higher was significantly associated with worse progression-free and cancer-specific survival.

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model Predicts Survival in Urothelial Cancer With Immunotherapy

Model, based on 6 factors, predicts overall survival for patients treated with atezolizumab

Active Surveillance Reasonable for NMIBC

Active Surveillance Reasonable for NMIBC

Appears to be a cost-effective strategy for patients with small size, stage pTa or pT1a recurrent tumors

Atezolizumab Safe, Beneficial Long-Term in mUC

Atezolizumab Safe, Beneficial Long-Term in mUC

In a 3-year study, toxic effects of atezolizumab remained manageable and responses durable.

Biopsy, Pathology Results Often Differ in UTUC

Biopsy, Pathology Results Often Differ in UTUC

Study results serve as a caution against relying on ureteroscopic biopsy to establish tumor grade and stage, researchers say.

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

Non-urothelial Bladder Cancer Type Affects Disease-Specific Survival

Patients with bladder adenocarcinomas have the best survival, whereas those with small cell carcinomas of the bladder have the worst.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

E-Cigarette Smoke Possibly Carcinogenic to Lung, Bladder

Nicotine and nicotine-derived nitrosamine ketone enhance mutational susceptibility in human cells.

Post-Cystectomy UTI Risk Linked to Comorbidities

Post-Cystectomy UTI Risk Linked to Comorbidities

A Charlson Comorbidity Index score of 2 or higher is an independent risk factor for urinary tract infections within 90 days following radical cystectomy for bladder cancer, study finds.

MRI Differentiates Low-Grade Bladder Tumors

MRI Differentiates Low-Grade Bladder Tumors

Diffusion-weighted imaging and use of higher field strengths further improve accuracy.

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

Adjuvant Radiation Therapy May Improve Survival After Cystectomy

The locoregional recurrence-free survival rate at 2 years was significantly higher for patients treated with chemotherapy plus RT versus those treated with chemotherapy alone.

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

Mortality High Among HD Patients Who Undergo Bladder Cancer Surgery

Patients on hemodialysis who undergo radical cystectomy for bladder cancer have 30-day and 5-year mortality rates of 9.3% and 87.9%, respectively, study finds.

Bladder Cancer Risk Higher in Urinary Stone Formers

Bladder Cancer Risk Higher in Urinary Stone Formers

Patients with versus without a history of urinary calculi had nearly 2-fold greater odds of bladder cancer, meta-analysis showed.

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

Active Surveillance Reasonable for Small, Low-Grade Bladder Tumors

40% of active surveillance events were deemed to require treatment.

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

Radical Cystectomy Offers Better Long-term MIBC Patient Survival

Chemoradiation for muscle-invasive bladder cancer is associated with a lower 1-year mortality risk versus radical cystectomy, but at year 2 and beyond, mortality risk is lower with radical cystectomy.

Quit Smoking Medications Not Found Effective

Quit Smoking Medications Not Found Effective

No evidence that varenicline, bupropion, or nicotine replacement increase probability of abstinence.

Few Immuno-Oncology Agents Effective by ASCO Standards

Few Immuno-Oncology Agents Effective by ASCO Standards

Durable survival, response rates rarely recognized as significant by current oncology value frameworks.

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy.

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

Bladder Cancer Neoadjuvant Chemotherapy on the Rise

The proportion of patients who received neoadjuvant chemotherapy for muscle-invasive bladder cancer prior to cystectomy rose from 4% to 27% of patients from 1994 to 2013.

Preop Aerobic Exercise May Improve Cystectomy Outcomes

Preop Aerobic Exercise May Improve Cystectomy Outcomes

A feasibility study involving 60 patients with bladder cancer sought to determine if preoperative vigorous cardiovascular activity would improve postsurgical outcomes.

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

Nearly Half of Cancers, Cancer Deaths Possibly Preventable

About 45.1% of cancer deaths and 42% of all incident cancers are linked to modifiable risk factors.

Trimodal Therapy and RC for MIBC Offer Similar Survival

Trimodal Therapy and RC for MIBC Offer Similar Survival

Mean disease-specific survival at 10 years was 50.9% for TMT and 57.8% for RC patients, a non-significant difference.

Urinary Arsenic Falling in Public Water Consumers

Urinary Arsenic Falling in Public Water Consumers

Reduction occurred after implementation of EPA's maximum contaminant level for arsenic

Fewer Cancer Patients Are Asked to Quit Smoking

Fewer Cancer Patients Are Asked to Quit Smoking

General practitioners less likely to support smoking cessation in patients with cancer than with CHD

Photocure Seeks Expanded Use of Blue Light Cystoscopy

Photocure Seeks Expanded Use of Blue Light Cystoscopy

FDA has accepted a supplemental New Drug Application asking to expand the labeling indication for Cysview to include use the bladder cancer-detecting system in the outpatient setting.

COBRA Score Gauges Mortality Risk After Cystectomy

COBRA Score Gauges Mortality Risk After Cystectomy

Tool incorporates the relative contribution of tumor stage, lymph node involvement.

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Hypermutated ctDNA: A Marker of Checkpoint Inhibitor Response?

Patients with high alteration number in variants of unknown significance had better outcomes.

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Immune Checkpoint Inhibitors Linked With Endocrine Dysfunction

Patients on combination therapy have increased risk of thyroid dysfunction and hypophysitis.

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

FGFR3-TACC3 Gene Fusion Found in Bladder Cancer

The researchers note that TACC3 is a mitotic spindle protein required for accurate segregation of chromosomes, and errors in segregation can lead to aneuploidy, contributing to cancer progression.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

CKD May Be a Risk Factor for NMIBC Recurrence, Progression

Stage G3b-5 chronic kidney disease independently predicted a nearly 2-fold increased risk recurrence and 3-fold increased risk of progression following transurethral resection.

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

Short-term Arterial Thromboembolism Risk Elevated in Cancer Patients

The six-month cumulative incidence of myocardial infarction was 2.0% and 0.7% in patients with cancer and controls, respectively.

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

Bladder Preservation Therapy Linked With Reduced Survival in MIBC

Radical cystectomy is associated with better survival, but findings suggest BPT may produce acceptable oncologic outcomes in appropriately selected patients.

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk

Instilling mitomycin C within 24 hours of TURBT vs after 2 weeks was associated with a 27% lower risk of recurrence.

Study: Cystectomy Complication Rate Not Improving

Study: Cystectomy Complication Rate Not Improving

Researchers find no significant change in overall complication rate from 2010 to 2015, but hospital length of stay and need for transfusion have declined.

TERT Test May Improve Detection of Bladder Cancer Recurrence

TERT Test May Improve Detection of Bladder Cancer Recurrence

In a study, a positive test result was associated with a 5-fold increased risk of recurrent non-muscle invasive bladder cancer.

Robotic, Open Radical Cystectomy Offer Similar Results

Robotic, Open Radical Cystectomy Offer Similar Results

A new review shows no significant differences in oncologic outcomes, long-term complications, and health-related quality of life between robot-assisted and open radical cystectomy.

Advanced Cancer Patients Ask for Secondary Germline Results

Advanced Cancer Patients Ask for Secondary Germline Results

The researchers found that 57% of participants expressed interest in learning their secondary germline findings, while 29% and 14%, respectively, were equivocal or disinterested.

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

Symptomatic Bladder Cancer Recurrence Linked With Worse Survival

Symptomatic recurrence was associated with a nearly 2-fold higher risk of death from the time of recurrence versus surveillance-detected recurrence.

Surgery, Combined Modality Offer Similar MIBC Outcomes

Surgery, Combined Modality Offer Similar MIBC Outcomes

Meta-analysis reveals no significant difference in overall-, disease-specific, and progression-free survival between radical cystectomy and radiation-based, bladder preservation therapy.

MIBC Patients Should Be Followed Long-term After Cystectomy

MIBC Patients Should Be Followed Long-term After Cystectomy

After recurrent disease, 5-year overall survival was worse among patients with late recurrence.

Worse Survival After Robotic Cystectomy Seen at Low-Volume Centers

Worse Survival After Robotic Cystectomy Seen at Low-Volume Centers

The researchers found lower overall survival among patients undergoing robot-assisted radical cystectomy at hospitals performing 10 or fewer procedures during 2010 to 2012.

Keytruda Approved for All Cancers With Specific Genetic Biomarker

Keytruda Approved for All Cancers With Specific Genetic Biomarker

Of 149 individuals with such tumors who took Keytruda in clinical trials, nearly 40% had a complete or partial remission.

Renal, Bladder Cancer Linked to Physical Inactivity

Renal, Bladder Cancer Linked to Physical Inactivity

Renal and bladder cancer patients were, respectively, 77% and 73% more likely to report lifetime physical inactivity than controls without cancer.

Pure Bladder Cancer Variants Linked to Worse Survival After RC

Pure Bladder Cancer Variants Linked to Worse Survival After RC

Patients with a pure variant had significantly lower survival odds than those with pure urothelial carcinoma over a median 6.5 years of follow up.

E-Cigarettes And Increased Risk Of Bladder Cancer Linked

E-Cigarettes And Increased Risk Of Bladder Cancer Linked

Research suggests that both cigarettes and e-cigarettes are tied to an increased risk of bladder cancer.

Real-World mUCB Patient Survival Worse Than in Clinical Trials

Real-World mUCB Patient Survival Worse Than in Clinical Trials

Just 1 in 4 patients diagnosed with metastatic urothelial carcinoma of the bladder survive for a year, according to US national registry data.

Robot-assisted Radical Cystectomy on the Rise

Robot-assisted Radical Cystectomy on the Rise

By 2014 to 2015, 1 in 3 bladder cancer surgical procedures performed in the United States were robot-assisted.

Neoadjuvant Chemo Benefits Some Variant MIBC Patients

Neoadjuvant Chemo Benefits Some Variant MIBC Patients

Researchers find prolonged survival among patients with neuroendocrine muscle-invasive bladder cancer.

Post-chemo PD-L1 Tied to Worse Prognosis in Bladder Cancer Pts

Post-chemo PD-L1 Tied to Worse Prognosis in Bladder Cancer Pts

Five-year cancer-specific survival rates were 48.1% and 69.6% for PD-L1 positive and negative patients, respectively.

Variant Histology Predicts Worse Bladder Cancer Outcomes

Variant Histology Predicts Worse Bladder Cancer Outcomes

Study finds a higher death risk following radical cystectomy for squamous cell and small cell carcinoma and micropapillary histologic subtypes.

VTE Risk Continues Long After Bladder Cancer Surgery

VTE Risk Continues Long After Bladder Cancer Surgery

The cumulative incidence of venous thromboembolism following radical cystectomy was nearly 6.7% over 10 years.

Post-Cystectomy Deaths Among HD Patients Seldom Due to Cancer

Post-Cystectomy Deaths Among HD Patients Seldom Due to Cancer

Following radical cystectomy for bladder cancer, end-stage renal disease patients are 3-4 times more likely to die from causes other than cancer.

Continent Diversion After Bladder Cancer Surgery on the Decline

Continent Diversion After Bladder Cancer Surgery on the Decline

Use of continent diversion procedures peaked in 2008, and has been decreasing since.

Bladder Cancer Patient Smoking Intensity Influences Survival

Bladder Cancer Patient Smoking Intensity Influences Survival

Patients smoking 1 or more packs of cigarettes per day had a higher risk of death compared with those who smoked less than 1.

Blue Light Cystoscopy Increases Bladder Cancer Detection Rate

Blue Light Cystoscopy Increases Bladder Cancer Detection Rate

Sensitivity is 90% for BLC compared with 75% for white light cystoscopy.

Bladder Cancer Recurrence Risk Lower in Metformin Users

Bladder Cancer Recurrence Risk Lower in Metformin Users

The protective effect of the diabetes drug metformin among patients who undergo surgery for non-muscle invasive bladder cancer is dose dependent, according to a study.

Blacks More Likely to Die From Metastatic Bladder Cancer

Blacks More Likely to Die From Metastatic Bladder Cancer

In a study, 2-year survival rates were 14.4% for whites compared with 6.5% for blacks.

Radical Cystectomy for Muscle-invasive UCB Offers Better Survival

Radical Cystectomy for Muscle-invasive UCB Offers Better Survival

Radical cystectomy is associated with better long-term overall survival than trimodal therapy, new study shows.

Pembrolizumab As Second-Line Tx for Urothelial Cancer Ups Survival

Pembrolizumab As Second-Line Tx for Urothelial Cancer Ups Survival

Use of the monoclonal antibody was associated with a 27% lower risk of death versus chemotherapy.

Pre-Cystectomy Chemo Does Not Up Survival in 'Real World' Setting

Pre-Cystectomy Chemo Does Not Up Survival in 'Real World' Setting

Finding contrasts with results of randomized clinical trials.

Bladder Surgery Complications Predicted by New Model

Bladder Surgery Complications Predicted by New Model

Nomograms specific to radical cystectomy currently do not exist to aid stratification of a patient's risks for complications.

Adjuvant Radiation Therapy Common in MIBC

Adjuvant Radiation Therapy Common in MIBC

Survey finds that 46% of radiation oncologists have administered ART to patients with muscle-invasive bladder cancer on at least one occasion.

Post-Radical Cystectomy Survival Outcomes Predicted by Preop NLR

Post-Radical Cystectomy Survival Outcomes Predicted by Preop NLR

A neutrophil-to-lymphocyte ratio below 3.09 is associated with significantly longer overall and disease-specific survival.

Nivolumab Approved for Refractory Urothelial Carcinoma

Nivolumab Approved for Refractory Urothelial Carcinoma

The drug is indicated for treating patients with locally advanced or metastatic disease that progresses despite platinum-containing chemotherapy.

Androgen Suppression May Prevent Intravesical Recurrence of NMIBC

Androgen Suppression May Prevent Intravesical Recurrence of NMIBC

During a median followup of 3.6 and 3.0 years intravesical recurrence developed in 4 (12.5%) and 59 men (30.1%) with and without androgen suppression therapy, respectively.

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

Significant Prostate Cancer Found in Advanced Bladder Cancer Patients

In a study, 53.1% of patients had concomitant prostate cancer in radical cystectomy specimens.

ASS1 Enzyme Loss Occurs in Invasive Bladder Cancer

ASS1 Enzyme Loss Occurs in Invasive Bladder Cancer

ASS1 loss occurs in invasive bladder cancer and is targetable by ADI-PEG 20.

Bladder Cancer-Pioglitazone Link Reasserted by FDA

Bladder Cancer-Pioglitazone Link Reasserted by FDA

After analyzing new data, the FDA again warns that the diabetes drug may be associated with an increased risk for bladder cancer.

Thromboembolic Events Common With Neoadjuvant Chemo for MIBC

Thromboembolic Events Common With Neoadjuvant Chemo for MIBC

Before and after radical cystectomy, thromboembolic events are common in bladder cancer patients who undergo neoadjuvant chemotherapy.

Low Vitamin D Linked to Bladder Cancer

Low Vitamin D Linked to Bladder Cancer

Low levels of vitamin D in the blood may prevent the cells within the bladder from stimulating an adequate response to abnormal cells.

Tumor Features Predict Post-Cystectomy Recurrence

Tumor Features Predict Post-Cystectomy Recurrence

Predictors of distant recurrences after robot-assisted radical cystectomy were mainly dictated by pathological tumor characteristics.

Nivolumab Shows Promise for Metastatic Urothelial Cancer

Nivolumab Shows Promise for Metastatic Urothelial Cancer

Based on a small study, investigators report encouraging efficacy and safety.

Bladder Cancer Progression Linked to Collagen Changes

Bladder Cancer Progression Linked to Collagen Changes

Increased type I collagen mRNA expression in the extracellular matrix microenvironment is associated with poor progression-free survival.

Infection Occurs in One Fourth of Radical Cystectomy Patients

Infection Occurs in One Fourth of Radical Cystectomy Patients

Patients who underwent a radical cystectomy (RC) developed postoperative infection after a median of 13 days.

Tight Glycemic Control May Help Diabetic NMIBC Patients

Tight Glycemic Control May Help Diabetic NMIBC Patients

Patients with diabetes had a significant 42% increased risk of recurrence of cancer and 79% increased risk of progression.

BCG Alone for Bladder CIS Offers Better Long-Term Outcomes

BCG Alone for Bladder CIS Offers Better Long-Term Outcomes

This approach is associated with a 26% decreased risk of disease recurrence at 15 years compared with alternating therapy with mitomycin C.

Tumor Site in Bladder Adenocarcinoma Predicts Survival Outcomes

Tumor Site in Bladder Adenocarcinoma Predicts Survival Outcomes

Tumors in the dome or urachus confer a better prognosis than those in the lateral wall and base, study finds.

Bladder Cancer Urine Test Accurate

Bladder Cancer Urine Test Accurate

Assay could cut down on cystoscopies, researchers say.

8% of Cancer Patients Develop a Second Malignancy

8% of Cancer Patients Develop a Second Malignancy

Second cancer was fatal in 55% of the cases studied.

Metformin May Have a Protective Effect in Bladder Cancer Patients

Metformin May Have a Protective Effect in Bladder Cancer Patients

Diabetics taking the drug had a significant 68% decreased risk of grade progression compared with diabetics not on the drug.

New Study Supports Use of Trimodal Therapy for MIBC

New Study Supports Use of Trimodal Therapy for MIBC

Researchers find no difference in 5-year disease-specific survival between multi-disciplinary bladder-sparing approach and radical cystectomy.

Early Recurrence After Laparoscopic Radical Cystectomy Explored

Early Recurrence After Laparoscopic Radical Cystectomy Explored

During first 24 months, 8.7% of patients with favorable pathological characteristics had progressed.

Gender Differences in Chemotherapy for Stage IV Bladder Cancer

Gender Differences in Chemotherapy for Stage IV Bladder Cancer

Women with stage IV bladder cancer have a lower median overall survival rate when compared to men.

Immunotherapy Helps Advanced Bladder Cancer Patients

Immunotherapy Helps Advanced Bladder Cancer Patients

About a quarter of older patients deemed too frail for chemo responded to atezolizumab.

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Four key lifestyle factors include weight, exercise, no smoking, and limiting alcohol.

Drug Cleared for Refractory Advanced Bladder Cancer

Drug Cleared for Refractory Advanced Bladder Cancer

Atezolizumab received accelerated FDA approval for patients whose disease has progressed despite platinum-based chemotherapy.

Leisure Activity Linked With Lower Risk of Several Cancers

Leisure Activity Linked With Lower Risk of Several Cancers

Findings for self-reported leisure-time physical activity of moderate to vigorous intensity.

Prostate, Bladder Cancer Linked to BPH

Prostate, Bladder Cancer Linked to BPH

In a meta-analysis, men with benign prostatic hyperplasia had a 2.9 times and 1.7 times increased incidence of prostate cancer and bladder cancer, respectively.

Pioglitazone Use, Bladder Cancer Linked

Pioglitazone Use, Bladder Cancer Linked

Bladder cancer risk increases with longer duration of use.

CKD Is a Risk Factor for UTUC

CKD Is a Risk Factor for UTUC

Researchers found elevated incidences of upper tract urothelial carcinoma (UTUC) in patients with CKD.

Cytoreductive RC Aids Survival of Metastatic Bladder Cancer Patients

Cytoreductive RC Aids Survival of Metastatic Bladder Cancer Patients

Patients who underwent debulking had significantly longer overall survival compared with those who did not (median 15.7 vs 10 months).

Neoadjuvant Chemo Rarely Used in Upper Tract Urothelial Cancer

Neoadjuvant Chemo Rarely Used in Upper Tract Urothelial Cancer

Therapy used in less than 5% of cases, even in those with higher clinical stage.

Bladder Preservation Therapy for MIBC Predicts Worse Survival

Bladder Preservation Therapy for MIBC Predicts Worse Survival

Mortality risk decreases with increasingly stringent BPT compared with radical cystectomy.

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