BPH Risk May Be Lower Among Allopurinol Users

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Men using allopurinol had a 22% lower risk of a BPH diagnosis.
Men using allopurinol had a 22% lower risk of a BPH diagnosis.

Allopurinol use is associated with a decreased risk of being diagnosed with benign prostatic hyperplasia (BPH), researchers reported online in Prostate Cancer and Prostatic Diseases.

In a study of 74,754 men, Ville Kukko, of the University of Tampere in Finland, and colleagues found that men using allopurinol had a 22% lower risk of a BPH diagnosis and a 19% and 33% decreased likelihood of BPH medication use and BPH-related surgery, respectively, after multivariable adjustment. The investigators observed that only body mass index (BMI) modified the risk association, with decreased risks found only among men with a BMI above the median (27.3 kg/m2).

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