Benign Prostatic Hyperplasia News Archive

Inactivity, Sitting Tied to LUTS in Men

Inactivity, Sitting Tied to LUTS in Men

Low physical activity may increase risk of lower urinary tract symptoms in study of Korean men

5α-Reductase Inhibitors Not Tied to High-Grade Prostate Cancer

5α-Reductase Inhibitors Not Tied to High-Grade Prostate Cancer

A previous study showed that using 5-ARIs to treat benign prostate hyperplasia decreased the risk of low-grade PCa.

BPH Risk May Be Lower Among Allopurinol Users

BPH Risk May Be Lower Among Allopurinol Users

Men using allopurinol had a 22% lower risk of a BPH diagnosis.

Sexual Adverse Effects of BPH Drug Treatment Clarified

Sexual Adverse Effects of BPH Drug Treatment Clarified

Decrease in scores on the Men's Sexual Health Questionnaire mostly due to ejaculation disorders.

Water Ablation for BPH Lessens Risk of Ejaculatory Dysfunction

Water Ablation for BPH Lessens Risk of Ejaculatory Dysfunction

A novel approach called "Aquablation" provides results comparable to TURP, but with a decreased likelihood of retrograde ejaculation.

Prostatic Urethral Lift Benefits Durable Out to 5 Years

Prostatic Urethral Lift Benefits Durable Out to 5 Years

Patients who underwent the minimally invasive procedure had a 36%, 50%, and 44% improvement in IPSS, quality of life, and peak flow rate, respectively, at 5 years.

Dutasteride Linked to Adverse Sexual Side Effects

Dutasteride Linked to Adverse Sexual Side Effects

Long-term use of the drug may predispose men to worsening erectile dysfunction and elevated risk of diabetes and non-alcoholic fatty liver disease.

'Real-World' Data Support PUL Use for LUTS

'Real-World' Data Support PUL Use for LUTS

PUL involves placement of small permanent metallic implants into the prostate that lift the lateral lobes away from the urethra and remove obstruction.

BPH Risk Linked to Use of Prescription NSAIDs

BPH Risk Linked to Use of Prescription NSAIDs

NSAID users had a 2-fold increased risk of BPH medication use, 59% increased risk of a recorded BPH diagnosis, and 61% increased risk for BPH surgery.

Prostate Photovaporization for BPH Beneficial Long-Term

Prostate Photovaporization for BPH Beneficial Long-Term

Average International Prostate Symptom Score remained low 5 years after the PVP laser procedure.

New-Onset Urinary Incontinence Common After HoLEP for BPH

New-Onset Urinary Incontinence Common After HoLEP for BPH

Researchers identified a predictor of new-onset UI after HoLEP that may aid urologists in clinical practice.

Water Vapor Ablation Eases BPH-Related Urinary Retention

Water Vapor Ablation Eases BPH-Related Urinary Retention

In a study, 81.1% of men were able to void after an average of 28 days after treatment.

HoLEP Feasible for BPH Patients With Low-risk Prostate Cancer

HoLEP Feasible for BPH Patients With Low-risk Prostate Cancer

The laser procedure was successful for 7 selected patients with enlarged prostates and LUTS harboring low-risk prostate cancer.

Prostatic Urethral Lift an Effective Option for Obstructed Patients

Prostatic Urethral Lift an Effective Option for Obstructed Patients

In a study, 86% of prostatic urethral lift patients experienced symptom relief in the first month.

BPH Development, Progression Linked to Sleep Problems

BPH Development, Progression Linked to Sleep Problems

Findings emerged from an analysis of data from 2588 men who participated in the REDUCE trial.

5ARIs Raise Risk of Self-Harm, Depression

5ARIs Raise Risk of Self-Harm, Depression

Study confirms small, but significant increases in the risks of these mental health problems among men taking the medication.

Persistent Erectile Dysfunction More Likely in 5ARI Users

Persistent Erectile Dysfunction More Likely in 5ARI Users

Longer use of finasteride at a dosage of 1.25 mg/day or less among men younger than 42 years is associated with greater risk, study finds.

Use of 5-ARIs May Reduce Blood Loss During TURP

Use of 5-ARIs May Reduce Blood Loss During TURP

The finasteride and dutasteride recipients had significantly less mean blood loss than the placebo group.

Prostatic Enlargement Linked to Obesity

Prostatic Enlargement Linked to Obesity

Benign prostatic hyperplasia is more likely to develop among men with larger waist circumference and body mass index and higher leptin levels.

Preop Foley Catheter Associated With TURP, TULIP Failure

Preop Foley Catheter Associated With TURP, TULIP Failure

Poor baseline functional status and having a Foley catheter preoperatively were associated with greater risk of TURP or TULIP failure.

Study: 5-ARIs Do Not Increase PCa Death Risk

Study: 5-ARIs Do Not Increase PCa Death Risk

New findings confirm previous reports.

Sexual Problems Linked to 5ARI Use for BPH

Sexual Problems Linked to 5ARI Use for BPH

Use of 5ARIs for BPH was associated with a statistically significant increased, pooled relative risk for sexual dysfunction.

PCa Treatment Can Relieve Pre-Existing LUTS

PCa Treatment Can Relieve Pre-Existing LUTS

Patients' pre-existing urinary problems influenced their perceptions of symptom relief after prostate cancer treatment.

Prostate, Bladder Cancer Linked to BPH

Prostate, Bladder Cancer Linked to BPH

In a meta-analysis, men with benign prostatic hyperplasia had a 2.9 times and 1.7 times increased incidence of prostate cancer and bladder cancer, respectively.

Bariatric Surgery May Ease LUTS in Obese Men

Bariatric Surgery May Ease LUTS in Obese Men

Study documents significant improvements in frequency, urgency, and nocturia.

HoLEP Improvements in BPH Symptoms Durable Out to 10 Years

HoLEP Improvements in BPH Symptoms Durable Out to 10 Years

Patients experienced a sustained decrease in AUA Symptom Score, and 95% of patients report being satisfied or very satisfied with the procedure.

Water Vapor Ablation Eases BPH/LUTS, Preserves Sexual Function

Water Vapor Ablation Eases BPH/LUTS, Preserves Sexual Function

Significant improvements in lower urinary tract symptoms are durable to 24 months, data show.

High PSA Predicts Elevated Risk of Lower Urinary Tract Symptoms

High PSA Predicts Elevated Risk of Lower Urinary Tract Symptoms

LUTS is 49% more likely to develop in men with a PSA level above 6 ng/mL versus 4 ng/mL or less.

Prostatic Urethral Lift Benefits Confirmed

Prostatic Urethral Lift Benefits Confirmed

New data show that the minimally invasive procedure is superior overall to TURP for treating BPH-related lower urinary tract symptoms.

Prostatic Artery Embolization May Reduce Nocturia in BPH

Prostatic Artery Embolization May Reduce Nocturia in BPH

Procedure partially blocks blood flow to the gland and appears to ease the need to urinate.

Silodosin Safe, Effective for Symptomatic BPH

Silodosin Safe, Effective for Symptomatic BPH

Three quarters of patients experienced significant improvements in lower urinary tract symptoms and quality of life observed and were satisfied with treatment.

PAE Effect on Prostate Zones Characterized

PAE Effect on Prostate Zones Characterized

Prostatic arterial embolization significantly reduced volumes of median lobes, central zones, peripheral zones, and whole prostate glands.

LUTS/BPH Treatments Provide Similar Improvement

LUTS/BPH Treatments Provide Similar Improvement

Men receiving common medical treatments for LUTS/BPH, including phytotherapy, experienced similar symptom relief.

Larger Prostates Predict Higher Risk of Lower Urinary Tract Symptoms

Larger Prostates Predict Higher Risk of Lower Urinary Tract Symptoms

The risk is 67% higher in men with a prostate size of 40.1-80 mL than those with smaller glands.

Small Prostates Predict More Severe BOO Symptoms

Small Prostates Predict More Severe BOO Symptoms

The risk of bladder outlet obstruction increased 34% per unit increase in serum PSA and decreased 23% per unit increase in maximal flow rate.

Testosterone Therapy Does Not Appear to Worsen LUTS/BPH

Testosterone Therapy Does Not Appear to Worsen LUTS/BPH

A recent review found little evidence to support severe lower urinary tract symptoms as a contraindication to TRT.

Patient Mood During Interventional Radiology May Affect Outcomes

Patient Mood During Interventional Radiology May Affect Outcomes

More adverse events seen when people undergoing interventional radiology have negative attitude.

Study: No Clinical Benefit for Botox in BPH

Study: No Clinical Benefit for Botox in BPH

Previous studies may have overlooked the placebo effect.

'Aquablation' May Relieve BPH Symptoms

'Aquablation' May Relieve BPH Symptoms

Use of high-velocity saline streams show promise in a small, first-in-man study.

Significant Response With Sham BPH Surgery

Significant Response With Sham BPH Surgery

Review shows significant change in symptom scores, maximum urinary flow in sham surgery arm

Age, Obesity Affect Gene Expression in Symptomatic BPH

Age, Obesity Affect Gene Expression in Symptomatic BPH

Age, obesity promote methylation, suppression of 5-reductase 2

Bladder Wall Thickness May Predict BOO Severity

Bladder Wall Thickness May Predict BOO Severity

Increasing thickness was associated with increasing number of poor indicators for bladder outlet obstruction in men with enlarged prostates.

Senior Cancer Patients Using CAM May Develop Urology Problems

Senior Cancer Patients Using CAM May Develop Urology Problems

CAM associated with polypharmacy, vision impairment, and urologic comorbidities.

Finasteride Use May Lower Bladder Cancer Risk in Men

Finasteride Use May Lower Bladder Cancer Risk in Men

The malignancy is 36% less likely to develop, after adjusting for age and smoking, data show.

Combo Superior for Overactive Bladder in BPH Patients

Combo Superior for Overactive Bladder in BPH Patients

Symptom improvement was greater in patients receiving tamsulosin plus darifenacin compared with tamsulosin monotherapy.

Predictors of Incidental Prostate Cancer After HoLEP Identified

Predictors of Incidental Prostate Cancer After HoLEP Identified

In a study, only older age and greater total PSA density were independently associated with an increased risk of a PCa diagnosis.

Conservative Treatment of BPH Okay for Some Bladder Stone Patients

Conservative Treatment of BPH Okay for Some Bladder Stone Patients

Patients with BPH and mild-to-moderate LUTS can be managed without immediate prostatic surgery, study suggests.

Novel BPH Procedure Eases Symptoms, Preserves Sexual Function

Novel BPH Procedure Eases Symptoms, Preserves Sexual Function

Prostatic urethral lift is minimally invasive and, according to a new study, the procedure's beneficial effects are durable out to 3 years.

Finasteride Can Decrease TURP-Related Blood Loss

Finasteride Can Decrease TURP-Related Blood Loss

Neither drug decreased operative time, prostate volume, or weight of gland resected.

Nocturia, Reassurance Prompt Men to Seek Medical Care

Nocturia, Reassurance Prompt Men to Seek Medical Care

Overall, men with LUTS showed remarkably poor knowledge about their symptoms.

Reoperation Rate Low After HoLEP for Enlarged Prostate

Reoperation Rate Low After HoLEP for Enlarged Prostate

Ten years after the laser procedure, no reoperation was needed for 95% of patients treated for symptomatic benign prostatic hyperplasia.

Urinary Symptoms May Raise Men's Bladder Cancer Risk

Urinary Symptoms May Raise Men's Bladder Cancer Risk

Men who reported having severe lower urinary tract symptoms (LUTS) had a 64% increased risk of the malignancy compared with those who reported no LUTS.

PAE Safe, Effective in BPH Patients with Medium and Large Prostates

PAE Safe, Effective in BPH Patients with Medium and Large Prostates

Outcomes were significantly better in men with large prostates, however.

Factors Associated with Depression in BPH Patients

Factors Associated with Depression in BPH Patients

Depression is prevalent among men with benign prostatic hyperplasia (BPH).

Reducing Sedentary Time May Cut BPH Risk

Reducing Sedentary Time May Cut BPH Risk

Men with lower levels of sedentary time had a significantly lower risk of benign prostatic hyperplasia (BPH).

Bullying Linked to LUTS in Children

Bullying Linked to LUTS in Children

Vancouver Symptom Score linked to bullying victimization and perpetrator scores

Metabolic Abnormalities Tied to Lower Urinary Tract Symptoms

Metabolic Abnormalities Tied to Lower Urinary Tract Symptoms

Metabolic syndrome linked to severity of LUTS; symptoms improve after bariatric surgery

Laser Surgery Gaining on Transurethral Resection (TURP) for Enlarged Prostate

Laser Surgery Gaining on Transurethral Resection (TURP) for Enlarged Prostate

From 2000 to 2011, transurethral resection of the prostate for benign prostatic hyperplasia (BPH) decreased and laser procedures increased.

Sitting to Urinate Eases Lower Urinary Tract Symptoms (LUTS)

Sitting to Urinate Eases Lower Urinary Tract Symptoms (LUTS)

Sitting to urinate is associated with an improved urodynamic profile in lower urinary tract symptoms (LUTS).

Many Urologists Not Strictly Adhering to BPH/LUTS Guidelines

Many Urologists Not Strictly Adhering to BPH/LUTS Guidelines

Many urologists not uniformly adhering to AUA guidelines for the management of benign prostatic hyperplasia/lower urinary tract symptoms.

Diabetic Neuropathy Raises Risk of Erectile Dysfunction (ED), Urinary Problems

Diabetic Neuropathy Raises Risk of Erectile Dysfunction (ED), Urinary Problems

Men with diabetic peripheral neuropathy have an increased occurrence of erectile dysfunction and lower-urinary-tract symptoms.

Moderate-to-Severe Lower Urinary Tract Symptoms (LUTS) Undertreated

Moderate-to-Severe Lower Urinary Tract Symptoms (LUTS) Undertreated

Only 10% of men aged 45-69 years who progress from no or mild to moderate or severe lower urinary tract symptoms are treated, study finds.

Reasons for Alpha Blocker Switch ID'd

Reasons for Alpha Blocker Switch ID'd

Lack of efficacy is the main reason for the switch.

Enlarged Prostate Urination Problems Could Be Eased by Sitting

Enlarged Prostate Urination Problems Could Be Eased by Sitting

Compared with standing, sitting was associated with significantly lower post-void residual volume.

HoLEP for Enlarged Prostate Preserves Sexual Function

HoLEP for Enlarged Prostate Preserves Sexual Function

Following surgery, improvement in sexual satisfaction correlated with improvements in all lower urinary tract symptoms.

Prostate Cancer Found in 1.4% of TURP Specimens

Prostate Cancer Found in 1.4% of TURP Specimens

This rate of incidental PCa detection is lower than found in previous studies.

TURP Better than PAE for Bladder Outlet Obstruction

TURP Better than PAE for Bladder Outlet Obstruction

Researchers compared transurethral resection of the prostate with prostate artery embolization in a randomized trial.

Doxazosin for BPH Has Minimal Effect on Sexual Function

Doxazosin for BPH Has Minimal Effect on Sexual Function

Ejaculatory function worsens, however, in men taking 5 alpha-reductase inhibitors.

Electronic Nose Differentiates Between PCa, BPH

Electronic Nose Differentiates Between PCa, BPH

Using leave-one-out cross-validation, sensitivity of 78 percent and specificity of 67 percent.

Ejaculatory Problems Linked to BPH Drugs

Ejaculatory Problems Linked to BPH Drugs

Alpha blockers and 5-alpha reductase inhibitors increase the risk of ejaculatory dysfunction, a systematic review and meta-analysis shows.

Modifiable Factors Help Predict Sexual Dysfunction in Older Men

Modifiable Factors Help Predict Sexual Dysfunction in Older Men

Range of risk factors identified for incidence and remission of ED, dyadic and solitary sexual desire.

BPH Surgery Outcomes Worse for Older, Non-Caucasian Men

BPH Surgery Outcomes Worse for Older, Non-Caucasian Men

New study also suggests that low preoperative hematocrit and albumin levels predict adverse outcomes.

Prostatic Artery Embolization Works for Enlarged Prostate

Prostatic Artery Embolization Works for Enlarged Prostate

Cumulative rates of clinical success were 87.2% at 3 months, 80.2% at 18 months, and 72.3% at 36 months (long term).

Enlarged Prostate Linked to Metabolic Syndrome

Enlarged Prostate Linked to Metabolic Syndrome

Older and obese men and those with low HDL cholesterol are more likely to have the syndrome as a determinant of prostatic enlargement.

TRT Doesn't Worsen Urinary Tract Symptoms

TRT Doesn't Worsen Urinary Tract Symptoms

About 30 percent of men experience an AUA symptoms index improvement of 3 or more points.

Prostatic Artery Embolization Safe, Effective for BPH

Early results from a small group of patients show a clinical success rate of 95%.

New Device Improves Urine Flow in BPH

The FDA has approved the first permanent implant to relieve low or blocked urine flow in men aged 50 years and older with BPH.

Hypogonadal Men with BPH Benefit from Dutasteride

Improvements observed in urinary symptoms and bone mineral density.

Hypogonadism Prevalence High in Obese BPH/LUTS Sufferers

Men with a body mass index of 30 kg/m2 or higher had a 39.3% prevalence of low testosterone, study finds.

TRT Eases Urinary Symptoms in Men with Late-Onset Hypogonadism

Significant declines in International Prostate Symptom Score observed, regardless of whether or not men lost weight or used a phosphodiesterase-5 inhibitor.

Data Point to Nocturia-Hypogonadism Link

Desmopressin appears to reduce nocturia and other LUTS while also significantly increasing testosterone levels in late-onset hypogonadism.

Ketoconazole May Have Role in Managing Acute Urinary Retention

Adding ketoconazole to tamsulosin increased the likelihood of a successful trial without catheter in men with benign prostatic obstruction.

ATP Nixed for Assessing Urinary Infection

Study results underscore the need for additional research to find other surrogate markers of urinary infection.

Testosterone Therapy Unlikely To Worsen Urinary Symptoms

Lower urinary tract symptoms actually improved in many men, with minimal change in PSA level.

Male LUTS Severity Linked to Constipation

Lower urinary tract symptoms (LUTS) are commonly attributed to benign prostatic hyperplasia.

Obesity Found to Increase BPH Risk

BPH has long been thought to be an inevitable function of genetic predisposition and age related changes in sex steroid hormones.

Saw Palmetto Has No Effect on PSA

Saw palmetto remains the most common herbal treatment for men with LUTS.

Coffee May Raise Risk of Lower Urinary Tract Symptoms

Orange or grapefruit juice consumption may be protective in men, study finds.

Dietary Vitamin C May Lower LUTS Progression Risk

Highest intake was associated with a 46% decreased progression risk compared with the lowest intake.

BPH-Related Acute Urinary Retention On the Rise

The incidence of emergency department visits rose 36% from 2007 to 2010 in California.

LUTS Not Worsened by Testosterone Replacement

Many men even experience an improvement in lower urinary tract symptoms.

Dual Drug Regimen Superior for Easing LUTS

Tadalafil plus finasteride improved symptoms scores better than finasteride plus placebo.

Higher Incidence of Bladder Cancer Without Hematuria Found

Lower urinary tract symptoms alone should raise suspicion for the malignancy.

Radical Prostatectomy May Prevent LUTS Progression

Following surgery, symptom severity declined significantly and remained stable over 10 years.

BPH Drug Prescribing Increasing in the U.S.

Alpha blockers are the mostly commonly prescribed drugs to treat LUTS secondary to BPH.

Voiding Parameters Remain Stable in Elderly Men

If patients are not bothered by symptoms, they do not necessarily require treatment, Australian researcher says.

High Doses of Saw Palmetto Safe Over 18 Months

High Doses of Saw Palmetto Safe Over 18 Months

No evidence of toxicity for patients given doses of up to 960 mg daily for up to 18 months.

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