Hyperthyroidism: McCune Albright Syndrome (MAS)
At a Glance McCune-Albright Syndrome (MAS) is a triad of bone lesions (polyostotic dysplasia), brown nonelevated pigmented areas of skin (cafe-au-lait spots),and endocrine dysfunction (usually precocious puberty). The disease is not inherited and is due to a post-zygotic activating mutation in the GNAS1 (alpha subunit of the G protein stimulating adenylate cyclase) gene. Since it…