OVERVIEW: What every practitioner needs to know about Primary Aldosteronism Primary aldosteronism is a group of disorders, originally described by JW Conn, in which there is a non-suppressible secretion of aldosterone and hypertension. Aldosterone is a salt-retaining hormone synthesized by the adrenal gland that is regulated by multiple factors, with the renin-angiotensin system and serum…
OVERVIEW: What every practitioner needs to know Are you sure your patient has congenital adrenal hyperplasia? What are the typical findings for this disease? Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders resulting from a deficiency in one of the enzymes involved in adrenal steroid synthesis. Impaired cortisol synthesis leads to chronic…
Overview: What every practitioner needs to know Are you sure your patient has adrenal insufficiency? What are the typical findings for this disease? Thomas Addison initially described a syndrome of weakness and hyperpigmentation associated with adrenal gland destruction in 1855. Adrenal insufficiency is caused by either primary adrenal failure or by secondary causes involving impairment…
