Robert Uzzo, MD, MBA, FACS, Author at Renal and Urology News
Robert Uzzo, MD, MBA, FACS

Robert Uzzo, MD, MBA, FACS

All articles by Robert Uzzo, MD, MBA, FACS

Genetic testing

Cancers, Viruses, and the Evolution of Fear

In The Emperor of All Maladies: A Biographic of Cancer, the oncologist Siddhartha Mukherjee, MD, intuits, “Down to their innate molecular core, cancer cells are hyperactive, survival-endowed, scrappy, fecund, inventive copies of ourselves.”1 Replace “cancer cells” with “viruses” and the quote holds equally true. Darwinian perpetrators of genomic dysregulation, many viruses have integrated foundationally into…

Lymphovascular Invasion Helps Predict Post-RP Biochemical Recurrence

Basic Science: The Tail That Wags the RCC Dog

I recently had reason to survey the progress made in renal cell cancer (RCC) over the last 70 or more years. In 1950, a patient who presented with metastatic RCC had a 0%-5% overall response rate (ORR) to the therapies of the time, with an anticipated overall survival (OS) of approximately 10 months. By 2005,…

Robert G. Uzzo, MD, FACS

The Negative Prostate Biopsy Dilemma

The role of PSA as a cancer screening tool has recently been evaluated by several large high profile studies with varying interpretations of the data. Regardless of where one stands on the debate, among the clinical dilemmas of PSA-based screening is the negative biopsy conundrum where the reality remains that the best one can offer is, “Good news Mr. Smith, I don’t think you have prostate cancer.”

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