At a Glance Patients with severe deficiency (<1% factor) develop symptoms within the first 6 years of life and present with umbilical stump bleeding, easy bruising and epistaxis. Acquired factor V deficiency causes, such as disseminated intravascular coagulation (DIC) and liver disease, must be excluded. Continue Reading What Tests Should I Request to Confirm My…
At a Glance Acquired isolated factor II deficiency is associated with factor II inhibitors. Based on their effect on prothrombin time (PT), partial thromboplastin time (PTT), and 1:1 mixing study, factor II inhibitors may be non-neutralizing or neutralizing. Continue Reading What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests…
At a Glance The diagnosis of congenital factor II deficiency is suggested by a lifelong history of mild to moderate bleeding in patients with prolonged prothrombin time (PT) and partial thromboplastin time (PTT). These include hemarthroses and intracranial bleeding, easy bruising, and postoperative bleeding. What Tests Should I Request to Confirm My Clinical Dx? In…
At a Glance Patient with liver disease or disseminated intravascular coagulation (DIC) on medications such as sodium valproate or L-asparaginase is likely to have fibrinogen deficiency (acquired). What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful? The following tests are useful to confirm a clinical diagnosis…
At a Glance Congenital disorders of fibrinogen can be divided into afibrinogenemia (characterized by absent or trace fibrinogen in the plasma or platelets), hypofibrinogenemia (characterized by decreased fibrinogen level in the plasma) and dysfibrinogenemia (characterized by synthesis of an abnormal fibrinogen molecule that does not function properly). Afibrinogenemia/hypofibrinogenemia clinical manifestations: Continue Reading Lifelong bleeding tendency…
