Matthew Tuck

All articles by Matthew Tuck


The term coagulopathy can denote problems with hypercoagulability or bleeding diatheses. This chapter will focus on the latter. See chapters on Disseminated Intravascular Coagulation, Heparin-Induced Thrombocytopenia, Antiphospholipid Antibody Syndrome, and Venous Hypercoagulability for more information on hypercoagulable states. The coagulation cascade is a complex interaction of coagulation factors, co-factors and enzyme complexes which together lead…

Disseminated Intravascular Coagulation

. Disseminated intravascular coagulation (DIC) is a secondary pathologic process with unbridled systemic activation of the intravascular coagulation system resulting in thrombosis and consumption of both platelets and coagulation factors followed by secondary fibrinolysis. A consensus definition offered by the International Society of Thrombosis and Haemostasis is: “DIC is an acquired syndrome characterized by the…

Next post in Hospital Medicine