Madelaine Haddican

Are You Confident of the Diagnosis? Systemic amyloidosis presenting with cutaneous manifestations is most commonly the result of primary systemic amyloidosis (Figure 1). Primary systemic amyloidosis can be subclassified into a type caused by an occult plasma cell dyscrasia, and a myeloma-associated type. Figure 1. Primary cutaneous amyloidosis in a patient without systemic involvement though…

Are You Confident of the Diagnosis? Characteristic findings on physical examination Macular amyloidosis typically presents as gray-brown pruritic macules, which gradually coelesce into patches with a rippled pattern involving the upper back (Figure 1) and less often the arms, chest and thighs. Macular amyloidosis is one of the more common types of primary localized cutaneous…

Are You Confident of the Diagnosis? Characteristic findings on physical examination Lichen amyloidosis is often described as a chronic, pruritic eruption of multiple discrete hyperkeratotic, nontender papules that may coalesce to form plaques with overlying lichenification (Figure 1). Lichen amyloidosis mostly occurs on the pretibial areas with occasional involvement of the arms, thighs, calves, ankles,…