Adding Talazoparib to Enzalutamide Appears Beneficial in mCRPC With HRR Mutations
Adding talazoparib to first-line treatment with enzalutamide improves rPFS in patients with HRR-deficient mCRPC, a phase 3 trial suggests.
Adding talazoparib to first-line treatment with enzalutamide improves rPFS in patients with HRR-deficient mCRPC, a phase 3 trial suggests.
New findings could have a role in conducting clinical trials of novel systemic therapies.
Cytoreductive nephrectomy before or after immunotherapy for metastatic clear cell renal cell carcinoma improves overall survival compared with immunotherapy alone, new findings suggest.
Findings from a prospective, randomized trial indicate that wound healing problems observed in early studies of high exposure to mTOR inhibitors can be prevented by using a dual regimen of everolimus and tacrolimus in low doses.
Patients receiving their first kidney transplant are at 18% higher risk for newly diagnosed atrial fibrillation if they were on hemodialysis rather than peritoneal dialysis prior to transplantation, a study found.
Although slow graft function does not necessitate dialysis, it is associated with a higher risk for graft failure and patient death, according to investigators.
Kidney transplant recipients with bacteremia may be more likely to require outpatient parenteral antibiotics if the infection is caused by bacteria that produce extended-spectrum beta-lactamases.
The phase 3 EMBARK trial involved more than 200 global sites and had 8 years of follow-up.
Following their research using pigs and brain-dead deceased donors, investigators with Keck Medicine at the University of Southern California in Los Angeles are gearing up to transplant a bladder into a living patient for the first time in history.
Some studies show that use of transurethral resection of the prostate, long the gold standard for managing enlarged prostates, is in decline, but it still remains the most popular choice among surgeons amid a wide range of options.