Gopi Astik

Sideroblastic anemia I. What every physician needs to know. Overview. Sideroblastic anemia occurs due to defects in heme synthesis pathway. In addition, defects in iron sulfur pathways or other important pathways in the mitochondria of erythroblasts, which indirectly impair heme production, are responsible for pathogenesis of sideroblastic anemia. A result of these abnormalities is decreased…