Eleanor Pollak

At a Glance Acquired factor VII deficiency may be suspected in a patient who has an increased prothrombin time (PT) with a normal activated partial thromboplastin time (aPTT) and no prior history of congenital factor VII deficiency. Isolated acquired factor VII deficiency is uncommon. However, this problem is typically associated with severe bleeding. What Tests…

At a Glance Factor VII deficiency is an inherited bleeding disorder associated with decreased levels of procoagulant factor VII. Factor VII, when appropriately cleaved, forms activated factor VIIa, the trigger of physiological blood clot formation. Deficiency of the factor VII protein, encoded by an autosomal gene on chromosome 13, normally does not cause bleeding manifestations,…