Bob Silver

All articles by Bob Silver

Antiphospholipid Syndrome

Antiphospholipid Syndrome (APS) 1. What every clinician should know Clinical features and incidence Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies recognizing epitopes expressed by negatively charged phospholipids, proteins or a phospholipid-protein complex. The true epitope in vivo is unknown. aPL are associated with a variety of medical and obstetric problems. Medical problems include:…

Inherited thrombophilia

Inherited thrombophilia. Prothrombotic disorder. Predisposition to blood clots. 1. What every clinician should know Thrombophilias are a heterogeneous group of conditions that dispose individuals to thromboembolic events (VTE). Most of these are venous thromboses. Normal hemostasis involves a delicate balance of procoagulant proteins that promote clot formation in case of bleeding or damaged endothelium and…

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