Gleason Score at Surgical Margin Affects BCR Risk

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Gleason score at the margin can better stratify biochemical recurrence-free rates, according to study findings.
Gleason score at the margin can better stratify biochemical recurrence-free rates, according to study findings.
The following article is part of conference coverage from the 2018 American Urological Association meeting in San Francisco. Renal and Urology News' staff will be reporting live on medical studies conducted by urologists and other specialists who are tops in their field in kidney stones, prostate cancer, kidney cancer, bladder cancer, enlarged prostate, and more. Check back for the latest news from AUA 2018. 

SAN FRANCISCO—After robot-assisted radical prostatectomy (RARP), the Gleason score at a positive surgical margin better predicts biochemical recurrence (BCR) risk than the highest Gleason score of the tumor specimen. Kent Kanao, MD, of Aichi Medical University in Japan, and his team presented the new study findings Friday at the American Urological Association meeting.

Of 475 patients undergoing RARP and pelvic lymph node dissection for localized prostate cancer, 11.6% experienced BCR during a mean 19.8 months of follow-up, they reported. Overall, 21.5% had positive surgical margins. For 1 in 4 of these patients, the Gleason Score at the margin was lower than the highest Gleason Score of the tumor specimen. Having a lower-grade margin was significantly associated with reduced risk for BCR. In a model, concordance was significantly higher for the Gleason score at the margin than within the specimen.

Gleason Score at the margin can better stratify BCR-free rates, results showed. “In addition to the highest Gleason Score in the specimen, the Gleason Score at the surgical margin should appear in the pathology report,” Dr Kanao and his colleagues.

Visit Renal and Urology News' conference section for continuous coverage from AUA 2018.

Reference

Kanao K, Sugie M, Muramatsu H, et al. Should Gleason score at the positive surgical margin appear on the pathology report for robot-assisted radical prostatectomy? Presented in poster format at the American Urological Association 2018 annual meeting, San Francisco, May 18–21. Abstract MP05-07. 

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