Predictors of Post-cystectomy C. difficile Infection Identified
Female sex and need for a blood transfusion are associated with development of Clostridium difficile infection following radical cystectomy.
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SAN FRANCISCO—Female sex and need for a blood transfusion and female sex are risk factors for Clostridium difficile infection (CDI) following radical cystectomy for bladder cancer, according to data presented at the American Urological Association 2018 annual meeting. Patients who experienced CDI had a significantly longer hospital stay.
In a nationally representative cohort of 3689 RC patients identified using the National Surgical Quality Improvement Program (NSQIP) database, post-operative CDI developed in 100 (2.7%). The CDI group had significantly higher proportions of women than men (35% vs 22.9%) and patients who had experienced intra- or post-operative bleeding complications requiring transfusion (51% vs 36%), Kevin A. Nguyen, MS, and colleagues from the Yale School of Medicine in New Haven, Connecticut, reported. The mean length of hospital stay was 13.9 days for the CDI patients compared with 9.1 days in the non-CDI group.
On multivariate analysis, female patients had a significant 58% increased risk of CDI compared with male patients, and patients who required a blood transfusion had a significant 53% increased risk.
Nguyen KA, Hsiang W, Syed JS, et al. Incidence, risk factors, and outcomes of C. difficile infection following radical cystectomy: A National Surgical Quality Improvement Program (NSQIP) study. Data presented in poster format at the American Urological Association 2018 annual meeting, San Francisco, May 18–21. Abstract MP10-14.