Partial vs Radical Nephrectomy Lowers Elderly Patient Mortality Risk

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Study shows that partial nephrectomy for small renal tumors is associated with lower risk of cancer-specific and other-cause mortality in patients aged 75 years and older.
Study shows that partial nephrectomy for small renal tumors is associated with lower risk of cancer-specific and other-cause mortality in patients aged 75 years and older.
The following article is part of conference coverage from the 2018 American Urological Association meeting in San Francisco. Renal and Urology News' staff will be reporting live on medical studies conducted by urologists and other specialists who are tops in their field in kidney stones, prostate cancer, kidney cancer, bladder cancer, enlarged prostate, and more. Check back for the latest news from AUA 2018. 

SAN FRANCISCO—Compared with radical nephrectomy (RN), partial nephrectomy (PN) for small renal tumors in elderly patients is associated with a lower risk of cancer-specific and other-cause mortality, researchers reported at the American Urological Association 2018 annual meeting.

Using 2004–2014 data from the Surveillance, Epidemiology and End Results (SEER) registry, Michele Marchioni, MD, of SS Annunziata Hospital "G.D'Annunzio" University of Chieti, Chieti, Italy, and colleagues identified 4541 surgically treated patients aged 75 years or older who had non-metastatic pT1a renal cell carcinoma. After they matched 1 RN to 1 PN patient by propensity score, the investigators had a study cohort of 2826 patients.

In multivariate analysis, PN was associated with a significant 36% and 33% decreased risk of cancer-specific and other-cause mortality, respectively. The investigators found no difference in 30-day mortality risk.

The authors concluded that PN should be given strong consideration in the treatment of small renal tumors, even for elderly patients.

Visit Renal and Urology News' conference section for continuous coverage from AUA 2018.

Reference

Marchioni M, Preisser F, Bandini M, et al. Comparison of partial vs. radical nephrectomy effect on other cause mortality, cancer specific mortality and 30-day mortality in patients older than 75 years. Oral presentation at the American Urological Association 2018 annual meeting, San Francisco, May 18–21. Abstract PD07-06.

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