Partial vs Radical Nephrectomy Lowers Elderly Patient Mortality Risk
Study shows that partial nephrectomy for small renal tumors is associated with lower risk of cancer-specific and other-cause mortality in patients aged 75 years and older.
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SAN FRANCISCO—Compared with radical nephrectomy (RN), partial nephrectomy (PN) for small renal tumors in elderly patients is associated with a lower risk of cancer-specific and other-cause mortality, researchers reported at the American Urological Association 2018 annual meeting.
Using 2004–2014 data from the Surveillance, Epidemiology and End Results (SEER) registry, Michele Marchioni, MD, of SS Annunziata Hospital "G.D'Annunzio" University of Chieti, Chieti, Italy, and colleagues identified 4541 surgically treated patients aged 75 years or older who had non-metastatic pT1a renal cell carcinoma. After they matched 1 RN to 1 PN patient by propensity score, the investigators had a study cohort of 2826 patients.
In multivariate analysis, PN was associated with a significant 36% and 33% decreased risk of cancer-specific and other-cause mortality, respectively. The investigators found no difference in 30-day mortality risk.
The authors concluded that PN should be given strong consideration in the treatment of small renal tumors, even for elderly patients.
Marchioni M, Preisser F, Bandini M, et al. Comparison of partial vs. radical nephrectomy effect on other cause mortality, cancer specific mortality and 30-day mortality in patients older than 75 years. Oral presentation at the American Urological Association 2018 annual meeting, San Francisco, May 18–21. Abstract PD07-06.