Bladder Cancer Patient Smoking Intensity Influences Survival
Patients smoking 1 or more packs of cigarettes per day had a higher risk of death compared with those who smoked less than 1.
|The following article is part of conference coverage from the 2017 American Urological Association meeting in Boston. Renal and Urology News' staff will be reporting live on medical studies conducted by urologists and other specialists who are tops in their field in kidney stones, prostate cancer, kidney cancer, bladder cancer, enlarged prostate, and more. Check back for the latest news from AUA 2017.|
BOSTON—Greater smoking intensity is associated with an increased risk of death among patients with bladder cancer, investigators reported at the American Urological Association 2017 annual meeting.
In a study of 12,793, adult bladder cancer patients with documented smoking history, a team led by Mark L. Gonzalgo, MD, PhD, Professor & Vice Chairman, Department of Urology, University of Miami Miller School of Medicine, found that the median overall survival (OS) time and 5-year OS rate were 4.4 years and 46.2%, respectively, for patients who smoked less than 1 pack of cigarettes per day (PPD) compared with 4.0 years and 43.5% for those who smoked 1 or more PPD.
On multivariate analysis, patients who smoked less than 1, 1–2, and more than 2 PPD had a statistically significant 11%, 26%, and 25% higher risk of death compared with those who never smoked.
Results also showed that black smokers had a statistically significant 33% higher risk of death than white smokers.
Of the 12,793 patients, 25%, 63%, and 12% smoked less than 1, 1–2, and more than 2 PPD, respectively.
“These data highlight the importance of smoking cessation for bladder cancer patients and underscore the need for patient education regarding the dangers of smoking,” Dr. Gonzalgo told Renal & Urology News. “Smoking cessation efforts should be targeted to this population because even a small reduction in the amount of smoking may still have a potential survival benefit.”
Savio LF, Koru-Sengul T, Lopategui DM, et al. Smoking intensity as a predictor of survival in bladder cancer patients: results from a population-based Florida Cancer Registry (1981-2009). [abstract]. J Urol 2017;197(4S):e35. Poster presented at the American Urological Association 2017 annual meeting in Boston on May 12, 2017. MP04-18.