Anemia News Archive

FDA Approves 'Biosimilar' Drug to Treat Certain Types of Anemia

FDA Approves 'Biosimilar' Drug to Treat Certain Types of Anemia

Retacrit is biosimilar to the drugs Epogen and Procrit.

Change in Red Blood Cell Distribution Width Tied With Mortality in HD

Change in Red Blood Cell Distribution Width Tied With Mortality in HD

In a study, increases in red blood cell distribution width during the first year of dialysis was associated with greater risks for death.

Vadadustat Maintains Hemoglobin Levels in Hemodialysis Patients

Vadadustat Maintains Hemoglobin Levels in Hemodialysis Patients

Patients' mean hemoglobin levels stayed relatively stable after converting from an erythropoiesis-stimulating agent to the investigational drug.

No Reduction in Platelets Found With IV Iron Use in CKD

No Reduction in Platelets Found With IV Iron Use in CKD

New study shows that IV iron repletion with sodium ferric gluconate complex increased platelet count significantly at week 3 post-infusion and non-significantly at week 4.

FDA Updates Triferic Label With New Safety Warning

FDA Updates Triferic Label With New Safety Warning

Clinicians should advise women who could become pregnant to use effective contraception before and after taking the anemia drug.

Anticoagulation Therapy May Prevent CV Events, Worsen Anemia in CKD

Anticoagulation Therapy May Prevent CV Events, Worsen Anemia in CKD

In a study, use of anticoagulants was associated with 85% fewer atherosclerotic events.

Calcitriol Found Not to Improve Hepcidin Levels in CKD

Calcitriol Found Not to Improve Hepcidin Levels in CKD

In a trial, oral calcitriol of 0.5 mcg daily did not reduce hepcidin levels in patients with stage 3 to 4 CKD.

Higher-Dose IV Iron Appears Safe in Dialysis

Higher-Dose IV Iron Appears Safe in Dialysis

Dialysis patients receiving more or less than 200 mg per month of IV iron had similar risks of death, infection, cardiovascular disease, and hospitalization, meta-analysis shows.

FDA Broadens Feraheme Use for Iron Deficiency Anemia

FDA Broadens Feraheme Use for Iron Deficiency Anemia

The Food and Drug Administration broadened the existing labeling for Feraheme (ferumoxytol injection) beyond the current chronic kidney disease indication.

Most CKD Patients With Anemia Show Limited Response to Oral Iron

Most CKD Patients With Anemia Show Limited Response to Oral Iron

In a 52-week trial, more than half of nondialysis-dependent chronic kidney disease patients with anemia treated with oral iron had no rise in their hemoglobin levels.

Anemia in Dialysis Patients Linked With Hemorrhagic Stroke

Anemia in Dialysis Patients Linked With Hemorrhagic Stroke

Patients with hemoglobin values of 9.7 g/dL or below had more than double the risk for hemorrhagic stroke compared with patients with hemoglobin values of 11.2 g/dL or above.

CERA Effective for Pediatric Hemodialysis Patients With Anemia

CERA Effective for Pediatric Hemodialysis Patients With Anemia

The safety profile of CERA is similar for children as for adults.

Lower IV Iron Dosing in Anemic Dialysis Patients May Be More Effective

Lower IV Iron Dosing in Anemic Dialysis Patients May Be More Effective

To support ESA therapy, IV iron at doses below 300 mg/month may be most effective for the average hemodialysis patient, according to an observational study.

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Ceruloplasmin a Possible Marker of CKD in Sickle Cell Anemia

Urinary ceruloplamin has potential to be a chronic kidney disease biomarker for patients with sickle cell anemia.

Darbepoetin Alfa Safe for Pediatric CKD Patients With Anemia

Darbepoetin Alfa Safe for Pediatric CKD Patients With Anemia

Researchers tested once weekly and biweekly administration of darbepoetin alfa in children aged 1 to 18 years not previously treated with an erythropoiesis-stimulating agent.

Residual Renal Function Not Linked to ESA Requirements

Residual Renal Function Not Linked to ESA Requirements

Researchers find no significant difference in the median erythropoietin resistance index between patients with versus without residual renal function.

Case: Treating Iron Deficiency Anemia in a Heart Failure Patient

Case: Treating Iron Deficiency Anemia in a Heart Failure Patient

To shed light on the often-challenging management of this common condition, a case of a hypothetical patient was presented to a doctor who specializes in advanced heart failure and transplant cardiology.

High ESA and Iron Doses Up CVD, Death Risk in Hemodialysis Patients

High ESA and Iron Doses Up CVD, Death Risk in Hemodialysis Patients

High doses of iron are associated with a significantly higher risk of cardiovascular disease, regardless of the dose of erythropoiesis-stimulating agent.

Ferric Citrate Approved for Anemia in CKD Patients

Ferric Citrate Approved for Anemia in CKD Patients

Study results show that the phosphate binder was superior to placebo in raising hemoglobin levels in non-dialysis-dependent CKD patients with iron-deficiency anemia.

IV Iron, Erythropoietin Equally Effective for Anemia in HD Patients

IV Iron, Erythropoietin Equally Effective for Anemia in HD Patients

Intravenous iron and erythropoietin produced a similar hemoglobin response among hemodialysis patients with moderate anemia.

Higher Hemoglobin Levels, Better Graft Function Linked

Higher Hemoglobin Levels, Better Graft Function Linked

The group targeting higher hemoglobin values experienced less decline in graft function.

Predialysis Anemia Treatment May Cut Mortality After HD Initiation

Predialysis Anemia Treatment May Cut Mortality After HD Initiation

HD patients with untreated or ineffectively treated anemia prior to dialysis initiation were more likely to die than those who had consistently well-treated anemia.

Anemia Raises ESRD Risk in Patients With Chronic Kidney Disease

Anemia Raises ESRD Risk in Patients With Chronic Kidney Disease

In a study, end-stage renal disease was 31% more likely to develop in CKD patients with versus without anemia.

Anemia Linked to High FGF23 Levels in CKD Patients

Anemia Linked to High FGF23 Levels in CKD Patients

CKD patients in the 3rd and 4th quartiles of c-terminal serum fibroblast growth factor 23 had a 74% and 73% higher risk for anemia compared with those in the 1st quartile.

Anemia Risk Factors in Diabetic Nephropathy Patients Identified

Anemia Risk Factors in Diabetic Nephropathy Patients Identified

Proteinuria and renin-angiotensin-aldosterone system inhibitors are independently associated with a significant 6-fold increased odds for anemia in patients with diabetic nephropathy.

Hereditary Hemochromatosis Patients Can Be Blood Donors

Hereditary Hemochromatosis Patients Can Be Blood Donors

No data to suggest that nonvoluntary nature of donations compromises safety of blood products.

Long-Acting ESAs Can Save Time, Costs

Long-Acting ESAs Can Save Time, Costs

Findings based upon time costs of preparation and administration per patient.

Daily Vitamin D Does Not Improve or Prevent Anemia

Daily Vitamin D Does Not Improve or Prevent Anemia

In a randomized study of patients with heart failure, including some with concurrent chronic kidney disease, patients who received vitamin D supplements or placebo had similar changes in hemoglobin levels over 36 months.

Anemia Common After Bariatric Surgery

Anemia Common After Bariatric Surgery

Anemia much more common among patients who did not have close follow-up with weight-loss surgeon

Patients Weigh Anemia Management Options

Patients Weigh Anemia Management Options

In a survey, hemodialysis patients were willing to accept medication risks to avoid red blood cell transfusion.

Anemia by Itself Linked With Early Death

Anemia by Itself Linked With Early Death

Study of Japanese individuals showed that anemia increased mortality risk even in the absence of chronic kidney disease.

Iron-based Binder Improves Phosphorus Levels in Dialysis Patients

Iron-based Binder Improves Phosphorus Levels in Dialysis Patients

The proportion of patients with serum phosphorus levels within target range rose from 22% to 65% within 6 months of starting ferric citrate treatment.

Ferritin Spike Soon After Hemodialysis Initiation Ups Mortality Risk

Ferritin Spike Soon After Hemodialysis Initiation Ups Mortality Risk

Up to a 49% higher risk of death observed in patients who had a 400 ng/mL increase in serum ferritin from baseline values compared with patients who had relatively stable ferritin levels.

Optimal Iron Status for Hemodialysis Patients Reported

Optimal Iron Status for Hemodialysis Patients Reported

Japanese researchers conclude that a serum ferritin level below 90 ng/mL and TSAT of 20% or higher was optimal for achieving a hemoglobin level of 10 g/dL or higher.

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Low Hemoglobin, Low SEVR Linked in Chronic Kidney Disease

Researchers used pulse wave analysis to measure subendocardial viability ratio, a measure of myocardial perfusion, and its association with hemoglobin.

RBC Distribution Width, Dialysis Patient Mortality Linked

RBC Distribution Width, Dialysis Patient Mortality Linked

As red blood cell distribution width increases, so does the risk of death from any cause.

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Non-Dialysis CKD Patients With Anemia Have More CVD, Worse QoL

Anemic patients were 41% and 80% more likely to have coronary artery disease and peripheral artery disease than non-anemic patients.

New Review Highlights Iron Deficiency Anemia in CKD

New Review Highlights Iron Deficiency Anemia in CKD

Intravenous iron should be strongly considered for patients treated with ESAs or hemodialysis, according to reviewers.

Low Testosterone Tied to Anemia Risk in Men With Type 2 Diabetes

Low Testosterone Tied to Anemia Risk in Men With Type 2 Diabetes

In type 2 diabetic male patients, a low testosterone level was found to be associated with anemia. These findings are consistent with previous reports.

Ferric Citrate Modestly Improves Anemia, Study Confirms

Ferric Citrate Modestly Improves Anemia, Study Confirms

Significantly more patients treated with ferric citrate increased their hemoglobin levels by 1 g/dL or more over 8 weeks.

Anemia Burden in Chronic Kidney Disease Described

Anemia Burden in Chronic Kidney Disease Described

The prevalence of low hemoglobin levels increases with declining renal function.

Triferic Pharmacokinetics Characterized

Triferic Pharmacokinetics Characterized

Ferric pyrophosphate citrate delivered via dialysate or intravenously rapidly donates iron to transferrin and is rapidly cleared from the circulation.

Anemia Indication Sought for Phosphate Binder

Anemia Indication Sought for Phosphate Binder

Company asks FDA to approve ferric citrate for iron deficiency anemia in patients with non-dialysis dependent chronic kidney disease.

Anemia, Bone Density Improve With Testosterone Replacement

Anemia, Bone Density Improve With Testosterone Replacement

Older men on TRT versus placebo for 1 year had improved hemoglobin levels and volumetric bone mineral density and estimated bone strength.

Red Blood Cell Size Linked With Mortality in CKD Patients

Red Blood Cell Size Linked With Mortality in CKD Patients

CKD patients with larger erythrocyte volumes had more than triple the risk of dying from cardiovascular causes, researchers reported.

Anemia Control Similar for Transplant Patients Re-entering Dialysis

Anemia Control Similar for Transplant Patients Re-entering Dialysis

Investigators observed no difference in hemoglobin level between transplant recipients and non-transplant CKD patients starting hemodialysis.

Female PD Patients Have Lower Hemoglobin Despite Anemia Treatment

Female PD Patients Have Lower Hemoglobin Despite Anemia Treatment

New and established peritoneal dialysis patients both showed this trend.

Iron-Based Phosphate Binder Safely Treats Anemia in CKD Patients

Iron-Based Phosphate Binder Safely Treats Anemia in CKD Patients

In a study 52.1% of patients receiving ferric citrate attained a 1.0 g/dL or greater increase in hemoglobin compared with just 19.1% receiving placebo.

IV Iron Formulations Associated With Similar Mortality

IV Iron Formulations Associated With Similar Mortality

New study finds no difference in all-cause and cause-specific mortality between iron sucrose and sodium ferric gluconate complex.

Shift in Anemia Management in CKD Patients Identified

Shift in Anemia Management in CKD Patients Identified

Use of ESAs declined while use of blood transfusions increased between 2008 and 2012.

Artificial Red Blood Cell Created

Artificial Red Blood Cell Created

The surface chemistry of the polymer reacts to the pH level of blood as it travels through the body.

Anemia in Non-Dialysis-Dependent CKD Patients Characterized

Anemia in Non-Dialysis-Dependent CKD Patients Characterized

The condition is present in more than half of Medicare patients with stage 3-5 chronic kidney disease.

Anemia Management During Early HD Varies By Country

Anemia Management During Early HD Varies By Country

US patients receive higher intravenous iron and ESA doses during the first year of hemodialysis compared with those in Europe.

Anemia Linked to Vitamin D Insufficiency in Children With CKD

Anemia Linked to Vitamin D Insufficiency in Children With CKD

Low vitamin D status was associated with a 2-fold higher risk for anemia.

Longer Red Blood Cell Storage Does Not Up Death After Transfusion

Longer Red Blood Cell Storage Does Not Up Death After Transfusion

Results were homogeneous, with differences in absolute mortality consistently less than 1% among the most extreme exposure categories.

Optimal Vitamin C Dose for Anemia in Hemodialysis Patients Unclear

Optimal Vitamin C Dose for Anemia in Hemodialysis Patients Unclear

Pending future research, patients should avoid taking more than 120 mg per day.

Cinacalcet Possibly Improves Anemia

Cinacalcet Possibly Improves Anemia

SHPT patients who received 6 months of cinacalcet treatment had a 10% increase in the odds of reaching target hemoglobin levels.

Dialysis Patient Outcomes Not Worse After Bundling, ESA Label Changes

Dialysis Patient Outcomes Not Worse After Bundling, ESA Label Changes

Study finds no increased risk of major adverse cardiovascular events and death.

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.

Lower ESA Use for Anemia Linked to Maintenance IV Iron

Lower ESA Use for Anemia Linked to Maintenance IV Iron

Management strategy also is associated with reduced mortality risk, but not achievement of hemoglobin targets.

High CRP Ups Kidney Failure Risk in Diabetic CKD Patients With Anemia

High CRP Ups Kidney Failure Risk in Diabetic CKD Patients With Anemia

End-stage renal disease is 32% more likely to develop in patients with C-reactive protein levels of 6.9 mg/L or higher vs 3.0 mg/L or lower.

Hypogonadism in Male HD Patients Linked to Poor ESA Response

Hypogonadism in Male HD Patients Linked to Poor ESA Response

Other risk factors include reduced muscle mass and lower levels of physical activity.

Hemodialysis Patient Hyporesponsiveness to ESAs Ups Death Risk

Hemodialysis Patient Hyporesponsiveness to ESAs Ups Death Risk

A recent study resulted in a new definition of less-than-optimal response to erythropoiesis-stimulating agents.

Most Cost-Effective Hb Target in Anemic CKD Patients Identified

Most Cost-Effective Hb Target in Anemic CKD Patients Identified

A hemoglobin level of 10.5 g/dL offers the optimal balance of cost and quality adjusted life years, researchers conclude.

Diabetes May Increase Anemia Risk in CKD Patients

Diabetes May Increase Anemia Risk in CKD Patients

The odds of developing anemia were 2-fold greater among patients with than without diabetes mellitus.

Anemic CKD Patients Have Lower Health-Related Quality of Life

Anemic CKD Patients Have Lower Health-Related Quality of Life

Anemia was associated with impaired activity levels at CKD stages 3, 4, and dialysis.

ESA Resistance Linked to Vitamin B6 Treatment

ESA Resistance Linked to Vitamin B6 Treatment

IV administration of vitamin B6 did not improve anemia or abnormal bone metabolism over 6 months.

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

High-Dose ESAs Found to Increase Cancer Risk in Dialysis Patients

Average weekly doses greater than 70 µg/week was associated with a 77% increased risk of cancer compared with no ESA exposure.

ESA-Resistance Linked to Early Death

ESA-Resistance Linked to Early Death

A high erythropoietin resistance index was associated with triple the risk for death from any cause.

Is Giving Small Iron Doses Per Dialysis Session Better for Patients?

Is Giving Small Iron Doses Per Dialysis Session Better for Patients?

Patients provided small doses of intravenous iron per treatment achieved higher hemoglobin levels than patients receiving weekly iron.

Hepatic Iron Overload May Be Common Before Dialysis

Hepatic Iron Overload May Be Common Before Dialysis

In a small study, 82% of patients had iron overload prior to hemodialysis initiation.

Anemia Prevalence, Treatment in Non-Dialysis CKD Varies by Country

Anemia Prevalence, Treatment in Non-Dialysis CKD Varies by Country

Less than half of anemic patients were prescribed ESAs or iron in the US and France, and a high percentage overall did not have iron indices measured.

ESA Doses Lower Among Dialysis Patients at Higher Elevations

ESA Doses Lower Among Dialysis Patients at Higher Elevations

Investigators find that the normalized mean ESA dose decreases as patients' elevation of residence increases.

Higher Conversion Ratio for Epoetin Beta to Darbepoetin Alfa

Higher Conversion Ratio for Epoetin Beta to Darbepoetin Alfa

Researchers confirmed higher dose conversion ratios in Taiwanese patients with stable hemoglobin.

Anemia Risk Factors in Peritoneal Dialysis Patients ID'd

Anemia Risk Factors in Peritoneal Dialysis Patients ID'd

New findings implicate transferrin saturation and nutritional status assessed by albumin.

TRT Found to Reduce Anemia in Hypogonadal Men

TRT Found to Reduce Anemia in Hypogonadal Men

After 54 weeks of treatment with testosterone undecanoate, anemia prevalence decreased from 29.6% to 10%.

Ferritin Levels Rising in Hemodialysis Patients

Ferritin Levels Rising in Hemodialysis Patients

Trend is independent of intravenous iron use and exposure to erythropoiesis-stimulating agents.

CERA Safe, Effective in Patient Subgroups

CERA Safe, Effective in Patient Subgroups

No new adverse events observed in patients with underlying cardiovascular risk factors who switched to continuous erythropoietin receptor activator.

Platelet/Lymphocyte Ratio May Predict ESA Resistance

Platelet/Lymphocyte Ratio May Predict ESA Resistance

Greater hyporesponsiveness to erythropoiesis-stimulating agents was associated with increased PLR ratios.

Dialysis Bundling, ESA Labeling Changes Did Not Increase Mortality

Dialysis Bundling, ESA Labeling Changes Did Not Increase Mortality

Observed rates of all-cause and cardiovascular mortality and myocardial infarction were consistent with expected rates, study shows.

Good Residual Renal Function Improves HD Patient Outcomes

Good Residual Renal Function Improves HD Patient Outcomes

Researchers observe significantly higher levels of albumin and hemoglobin and better calcium and phosphate metabolism.

ESAs Don't Improve Anemia Patients' Quality of Life

ESAs Don't Improve Anemia Patients' Quality of Life

Based on effect of erythropoietin-stimulating agents for higher hemoglobin targets.

ESRD Anemia Responds to Investigational Oral Drug

ESRD Anemia Responds to Investigational Oral Drug

In a phase 2 trial, roxadustat maintained hemoglobin levels over 19 weeks as well as epoetin alfa.

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.

Earlier ESA Initiation May Improve Renal Outcomes

Earlier ESA Initiation May Improve Renal Outcomes

Study shows benefit of initiating epoetin beta therapy at hemoglobin levels not less than 10 g/dL in non-dialysis CKD patients.

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

Recombinant Erythropoietin Benefits Non-Dialysis CKD Patients

Treatment corrects anemia and improves quality of life, according to a systemic review.

Ergocalciferol Supplements Improve Vitamin D Deficiency, Not Anemia

Ergocalciferol Supplements Improve Vitamin D Deficiency, Not Anemia

Six-months of supplementation has no impact on epoetin utilization in HD patients with low 25(OH)D.

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

Hemoglobin Levels May Discriminate CKD Stages in the Elderly

In a study, investigators observed that levels were higher in those with stage 3a than stage 3b chronic kidney disease.

Weekly ESA Dosing at Dialysis Centers May Offer Time Savings

Weekly ESA Dosing at Dialysis Centers May Offer Time Savings

The estimated potential staff time savings totaled 23 hours for an average facility with 70 patients, researchers found.

Ferumoxytol Similar in Safety to Other IV Iron Products

Ferumoxytol Similar in Safety to Other IV Iron Products

Rates of death and important non-fatal outcomes between ferumoxytol and iron sucrose or sodium ferric gluconate do not differ significantly.

Transfusion, Mortality Link Varies With Hemoglobin, Heart Disease

Transfusion, Mortality Link Varies With Hemoglobin, Heart Disease

For ICU patients, hemoglobin level thresholds vary with presence of comorbid heart disease.

Anaphylaxis Risk Among IV Iron Products Ranked

Anaphylaxis Risk Among IV Iron Products Ranked

Risk of anaphylaxis associated with IV iron highest for iron dextran, lowest for iron sucrose.

Lower Pre-ESRD Hemoglobin Predicts Better Dialysis Patient Survival

Lower Pre-ESRD Hemoglobin Predicts Better Dialysis Patient Survival

Having hemoglobin 9-11 g/dL prior to dialysis provided the best life expectancy.

Red Cell Distribution Width Linked With Mortality in Dialysis

Red Cell Distribution Width Linked With Mortality in Dialysis

It is unclear whether RDW is a risk factor for early death or a byproduct of biological and metabolic imbalances.

Statins May Improve Response to Erythropoiesis-Stimulating Agents

Statins May Improve Response to Erythropoiesis-Stimulating Agents

Patients prescribed the lipid-lowering agents were less likely to exhibit hyporesponsiveness to the medications.

Erythropoietin Resistance More Likely in Female Dialysis Patients

Erythropoietin Resistance More Likely in Female Dialysis Patients

Study finds no gender differences in parathyroid hormone, ferritin, Kt/V, or age.

Vitamin C Found to Decrease Erythropoietin Requirement

Vitamin C Found to Decrease Erythropoietin Requirement

In a study, the mean hemoglobin level increased significantly in hemodialysis patients with functional iron deficiency.

Iron Deficiency Ups Mortality in Renal Transplant Recipients

Iron Deficiency Ups Mortality in Renal Transplant Recipients

The association is independent of anemia, according to researchers.

Anemia More Severe in Hemodialysis Patients with PEW

Anemia More Severe in Hemodialysis Patients with PEW

Patients with vs. without protein-energy wasting syndrome had a significantly lower mean hemoglobin level.

HCV Ups Anemia-Related Event Risks in Hemodialysis Patients

HCV Ups Anemia-Related Event Risks in Hemodialysis Patients

Hepatitis C viral infection found to increase likelihood of requiring blood transfusions and hemoglobin levels dropping below 8.5 g/dL.

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