Acute Kidney Injury
In a meta-analysis, the risks for premature death nearly doubled, CKD nearly tripled, and ESRD nearly quintupled after an episode of acute kidney injury.
In a study, nearly 1 in 10 cancer patients on systemic therapy experienced an episode of acute kidney injury.
The risk of post-contrast acute kidney injury increased with decreasing renal function.
Two molecular sub-phenotypes perform differently in response to vasopressin therapy.
In a Canadian study of patients who experienced AKI during hospitalization, treatment with an ACEI or ARB within 6 months of discharge was associated with a 15% lower risk for death after 2 years.
Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient acute kidney injury.November 02, 2018
1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker within six months was associated with decreased mortality. 2. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use was also associated with increased risk of hospitalization for a renal cause (hyperkalemia, 
In a propensity score-matched analysis, AKI was associated with a 3.4-fold greater risk of dementia.
Statin use vs non-use among patients hospitalized with dialysis-requiring acute kidney injury is associated with decreased risks of 1-year and in-hospital all-cause mortality, a study found.
Individuals with a serum bicarbonate level below 24 mEq/L have a 2-fold increased risk of AKI compared with those with a level of 25-28 mEq/L.
Early and delayed renal-replacement therapy for septic shock associated acute kidney injury show similar mortality: the IDEAL-ICU trialOctober 17, 2018
1. Among patients with septic shock and acute kidney injury (AKI), there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT). 2. Patients in the delayed group had significantly more days free from RRT, with no significant differences compared to the early 
More than half of patients died prematurely, regardless of whether they received early or delayed RRT.
Use of ultra-low contrast volume during percutaneous coronary intervention was associated with 32% decreased odds of acute kidney injury, investigators report.
Stage 1 acute kidney injury accounted for the biggest growth in incidence rate.
Serum uric acid levels above the median prior to cardiac surgery is independently associated with 5.5-fold increased odds of postoperative acute kidney injury.
Sodium bicarbonate infusions decreased the risk of death or organ failure among ICU patients with acute kidney injury and severe metabolic acidemia.
Proteinuria at the time of surgery is associated with an elevated risk of postoperative acute kidney injury and 30-day unplanned readmission.
Reduced kidney injury, better kidney function seen after prolonged cardiopulmonary bypass.
According to the authors, this is the first study to identify medications most commonly reported for a specific adverse reaction using the FAERS database.
For hospitalized patients, risk also increased for those receiving 3 or more CNS antidepressants.
If the study findings are confirmed, earlier detection of heart failure could save lives, according to researchers.
Early acetaminophen exposure after pediatric cardiac surgery may reduce rate of acute kidney injury.
Fluid restriction has no impact on disability-free survival; increases risk of acute kidney injury
Cystatin C as biomarker, kidney function marker linked to 20-year cumulative incidence of HI.
Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.
In the most comprehensive study of its kind, investigators find that acute kidney injury not requiring hospitalization is associated with a 90% increased mortality risk.
In a large study, caffeine administration to neonates born before 33 weeks' gestation reduced their odds of experiencing AKI by a significant 80%.
AKI hospitalizations were 4 times more likely among patients with diabetes.
Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trialMarch 07, 2018
1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating Level: 1 (Excellent) Study 
No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.
AKI associated with 27% increased risk of hypoglycemia among patients with diabetes.
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)