Acute Kidney Injury News Archive

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

Acute Kidney Injury Hospitalizations Increased 2000 to 2014

AKI hospitalizations were 4 times more likely among patients with diabetes.

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD

No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

Acute Kidney Injury Increases Risk for Hypoglycemia in Diabetes Pts

AKI associated with 27% increased risk of hypoglycemia among patients with diabetes.

High Risk of AKI After Non-Kidney Transplants in Children

High Risk of AKI After Non-Kidney Transplants in Children

High risk of AKI in first year after non-kidney solid organ transplant; in turn, increases CKD risk.

Early RRT for Acute Kidney Injury Not Superior

Early RRT for Acute Kidney Injury Not Superior

Early and late initiation of renal replacement therapy for AKI in critically ill patients are associated with similar long-term risks of death, chronic kidney disease, and end-stage renal disease.

AKI With C. difficile Admissions Increasing

AKI With C. difficile Admissions Increasing

Though hospital admission rates have increased, inpatient death has improved from 2003 to 2012.

Acute Kidney Injury in CCU Patients Linked to Cystatin C

Acute Kidney Injury in CCU Patients Linked to Cystatin C

Among patients admitted to a coronary care unit, the highest quartile of serum cystatin C levels was associated with a 9.6-fold increased risk of AKI compared with the lowest quartile.

Kidney Risks Differ Among Oral Anticoagulant Drugs for AFib

Kidney Risks Differ Among Oral Anticoagulant Drugs for AFib

Dabigatran and rivaroxaban were associated with lower risks of adverse renal outcomes compared with warfarin.

Acute Kidney Injury Predicts Heart Failure

Acute Kidney Injury Predicts Heart Failure

In a study of hospitalized US veterans, AKI was associated with a 23% increased risk of heart failure compared with the absence of AKI.

New Model Improves Predictions of Advanced CKD Following AKI

New Model Improves Predictions of Advanced CKD Following AKI

The model was based on 6 variables readily obtained at hospital discharge.

IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography

IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography

Contrast-associated acute kidney injury occurred in 9.5% and 9.1% of patients receiving IV sodium bicarbonate and acetylcysteine, respectively, rates which did not differ significantly from the 8.3% rate among those receiving IV sodium chloride.

Acute Kidney Injury After Cardiac Revascularization on the Rise

Acute Kidney Injury After Cardiac Revascularization on the Rise

From 2004 to 2012, the incidence of AKI increased from 4.9% to 14.2% among CABG patients and from 2.7% to 8.8% among PCI patients.

AKI More Likely After Intracoronary Versus IV Contrast Delivery

AKI More Likely After Intracoronary Versus IV Contrast Delivery

In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.

ESRD Frequently Follows Dialysis-Dependent AKI

ESRD Frequently Follows Dialysis-Dependent AKI

In a study, end-stage renal disease developed in 56% of patients discharged from a hospital with acute kidney injury requiring dialysis.

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

AKI at 12 and 24 Hours After PCI Independently Ups Death Risk

Timing of AKI after urgent percutaneous coronary intervention affects risk of significant kidney function loss 1 year after the procedure.

Intensive Blood Pressure Control May Not Benefit CKD Patients

Intensive Blood Pressure Control May Not Benefit CKD Patients

Post hoc analysis of SPRINT finds no significant difference in the incidence of fatal and nonfatal cardiovascular events among patients with moderate-to-advanced chronic kidney disease.

VTE Prophylaxis Inadequate for Acute Kidney Injury Patients

VTE Prophylaxis Inadequate for Acute Kidney Injury Patients

In a study, AKI sufferers had an increased rate of venous thromboembolism whether they receive heparin prophylaxis or not.

Acute Kidney Injury Follow-up Falls Short

Acute Kidney Injury Follow-up Falls Short

Three-quarters of patients hospitalized with acute kidney injury in Alberta, Canada did not visit a kidney specialist within 12 months of discharge.

Urinary Biomarker May Predict AKI After Heart Surgery

Urinary Biomarker May Predict AKI After Heart Surgery

Elevated levels of the two proteins can predict risk of acute kidney injury.

Vancomycin, Piperacillin/Tazobactam Combo Ups AKI in Kids

Vancomycin, Piperacillin/Tazobactam Combo Ups AKI in Kids

Risk of AKI in hospitalized children higher than with IV vancomycin, other antipseudomonal -lactam

AKI After Computed Tomography Not Tied to Contrast

AKI After Computed Tomography Not Tied to Contrast

AKI occurred with similar frequency among patients who did and did not receive contrast medium.

AKI Risks Not Up With SGLT2 Inhibitors

AKI Risks Not Up With SGLT2 Inhibitors

Findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes.

Mortality Up for ER Patients Discharged With AKI

Mortality Up for ER Patients Discharged With AKI

Higher mortality was seen in association with an emergency department discharge with acute kidney injury vs no acute kidney injury.

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

Post-PCI Acute Kidney Injury Not Linked to Contrast Use

Myocardial infarction patients who underwent percutaneous coronary intervention had an AKI rate similar to those who did not have the procedure.

AKI Predictors in PE Patients Identified

AKI Predictors in PE Patients Identified

Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.

Children With Diabetic Ketoacidosis at High Risk of AKI

Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.

Marathon Runners May Develop AKI, Tubular Injury

Marathon Runners May Develop AKI, Tubular Injury

An increase in injury and repair biomarker levels suggests structural damage to renal tubules occurring after marathon.

Chronic Kidney Disease More Likely in PPI Users

Chronic Kidney Disease More Likely in PPI Users

Proton pump inhibitors need not first cause acute kidney injury for CKD risk to be elevated.

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Furosemide With Matched Hydration Prevents Contrast Nephropathy

Compared with control treatment, RenalGuard therapy correlated with significantly reduced CI-AKI, as well as a reduced need for renal replacement therapy.

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Kidney Function Predicts Hospital Discharge, Mortality After Stroke

Patients with an eGFR below 60 mL/min/1.73 m2 were more likely to die in the hospital or be discharged to hospice.

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

Platelet Counts Linked to AKI Severity in Pediatric Open-Heart Surgery

There is a strong association between magnified nadir platelet counts and the severity of AKI.

Previous AKI Episode Associated With Pregnancy Risks

Previous AKI Episode Associated With Pregnancy Risks

Women with r-AKI had increased rates of preeclampsia and premature infant births, compared with controls.

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

AKI Is a Risk Factor for Delirium, Coma in Critically Ill

The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma as was stage 3 acute kidney injury.

Severe AKI in Young ICU Patients Predicts Higher Mortality

Severe AKI in Young ICU Patients Predicts Higher Mortality

The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.

Early RRT for AKI May Lower Risk of Dialysis Dependence

Early RRT for AKI May Lower Risk of Dialysis Dependence

It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors Linked to Worse Post-Surgical Kidney Function ID'd

Factors including low preoperative mean arterial BP tied to increases in eGFR, kidney injury.

Genetic Loci Linked to Acute Kidney Injury

Genetic Loci Linked to Acute Kidney Injury

Four single-nucleotide polymorphisms at two loci identified in discovery, replication populations.

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia Linked With Mortality in Septic AKI

Hyperphosphatemia was associated with more than double the risk of death from any cause.

Better AKI Patient Survival Linked to Negative Fluid Balance

Better AKI Patient Survival Linked to Negative Fluid Balance

The mortality rate among patients with negative fluid balance was just 7.4%, compared with 43.5% for patients with a positive fluid balance.

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

Acute Kidney Injury Progression Predicted by Urinary Biomarkers

Study identifies 3 biomarkers that could detect increasing risk of worsening AKI in patients with acute cardiorenal syndrome.

More Intensive Renal Replacement Therapy Possibly Harmful

More Intensive Renal Replacement Therapy Possibly Harmful

This approach is associated with lower urine output during the first 7 days of therapy.

Drug Combinations May Increase Acute Kidney Injury Risk

Drug Combinations May Increase Acute Kidney Injury Risk

NSAIDs + diuretics with or without additional renin-angiotensin aldosterone agents demonstrated the strongest level of evidence.

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

Acute Kidney Injury May Up Long-Term Risk of Cardiovascular Mortality

In a meta-analysis, AKI was associated with an 86% increased risk of CV-related death and 38% increased risk of other major CV events.

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

FDA Strengthens AKI Warning for Some SGLT2 Inhibitors

The Food and Drug Administration (FDA) announced it is strengthening the current warning about the risk of acute kidney injury for drug products containing canagliflozin (Invokana, Invokamet) and dapagliflozin (Farxiga, Xigduo XR).

CKD Progression After Acute Kidney Injury Characterized

CKD Progression After Acute Kidney Injury Characterized

Male gender, diabetes, and renal function decline at 90 days implicated as risk factors; patients rarely progress to end-stage renal disease.

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Fluid Overload at RRT Initiation Ups AKI Patients' Long-Term Mortality

Japanese study demonstrates a 2-fold increased risk of death from any cause.

Risk Factors ID'd for Early Mortality After Starting CRRT

Risk Factors ID'd for Early Mortality After Starting CRRT

High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Critically Ill Acute Kidney Injury Patients Benefit From Early RRT

Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.

In-Hospital Mortality From Dialysis-Requiring AKI Declining

In-Hospital Mortality From Dialysis-Requiring AKI Declining

Patients were 40% less likely to die in 2011 compared with 2001, study finds.

No Survival Advantage With Early Renal-Replacement Therapy in AKI

No Survival Advantage With Early Renal-Replacement Therapy in AKI

Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

Hospital- vs Community-Acquired AKI

Hospital- vs Community-Acquired AKI

Poor long-term outcomes found even in patients with community-acquired AKI but not hospitalized.

No Benefit, Kidney Risk Found for Perioperative Statins

No Benefit, Kidney Risk Found for Perioperative Statins

Statins don't prevent complications and may cause acute kidney injury, researchers report.

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

ACEI/ARBs Improve AMI Outcomes Regardless of Kidney Function

Treatment linked to improved long-term survival, regardless of underlying kidney function.

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CMX-2043 Did Not Reduce Contrast-Induced Nephropathy

CARIN trial reported no significant differences in acute kidney injury incidence between novel compound CMX-2043 and placebo.

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

Aliskiren/Enalapril Combo Results in More Harms in Heart Failure

The addition of aliskiren to enalapril led to more adverse events in patients with chronic heart failure without an increase in benefit.

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

ACE Inhibitors, ARBs Comparable for Diabetic Retinopathy Patients

Study finds no significant difference in the rates of all-cause mortality, major cardiac events, and hospital admission with hyperkalemia or AKI.

World Kidney Day 2016 Focuses on Disease in Childhood

World Kidney Day 2016 Focuses on Disease in Childhood

10% of the population worldwide is impacted by some form of kidney damage.

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

Peri-Op Statin Therapy Does Not Prevent AKI After Cardiac Surgery

The trial was stopped for futility after 615 patients completed the study.

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

AKI After Cardiac Surgery Linked to Worse Survival, Renal Outcomes

Acute kidney injury increased the likelihood of advanced chronic kidney disease in elderly patients.

Statin Use May Raise Kidney Disease Risk

Statin Use May Raise Kidney Disease Risk

Statin users had 30% increased odds of acute kidney injury and 36% increased odds of chronic kidney disease compared with non-users.

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

IV Iron Safe for Treating Anemia in Acute Kidney Injury Patients

In a case-control study, the treatment did not adversely affect mortality or recovery from AKI.

AKI Diagnostic Testing May Be Excessive

AKI Diagnostic Testing May Be Excessive

Results of some urine and blood tests are unlikely to affect diagnosis or management of acute kidney injury.

CKD Risk Following Inpatient Acute Kidney Injury Characterized

CKD Risk Following Inpatient Acute Kidney Injury Characterized

Even mild AKI with rapid recovery is associated with increased risk of chronic kidney disease stage 3 or higher.

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Long-Term Cardiovascular Mortality Linked to Post-Op AKI, CKD

Even surgery patients with stage 1 AKI without true organ damage had a 43% increase in cardiovascular mortality risk within 10 years compared with patients with no kidney disease.

CKD Progression to Stage 4 Predicts Increased Death Risk

CKD Progression to Stage 4 Predicts Increased Death Risk

CKD progression from stage 3 to stage 4 also was associated with increased risks of acute kidney injury and hospitalization.

Renal Biomarkers Predict Diabetes Outcomes

Renal Biomarkers Predict Diabetes Outcomes

AKI, albuminuria, eGFR considered separately or together can predict adverse outcomes in diabetes.

Tenofovir-Linked Acute Kidney Injury Common in HIV

Tenofovir-Linked Acute Kidney Injury Common in HIV

Fewer than half of patients with TFD-linked AKI had renal function recovery after drug withdrawal.

Acute Kidney Injury More Likely in African Americans

Acute Kidney Injury More Likely in African Americans

Increased risk observed in the VA health system unlikely to be fully explained by disparities in access to care.

Acute Kidney Injury Raises Heart Failure Risk

Acute Kidney Injury Raises Heart Failure Risk

AKI is independently associated with a 27% increased risk of heart failure, according to a study of hospitalized U.S. veterans.

Acute Kidney Injury Risk Relatively Low After GI Surgery

Acute Kidney Injury Risk Relatively Low After GI Surgery

AKI developed in 2.1% of operations and was more common after major, open, and acute surgeries.

Buffered Crystalloid Solution Doesn't Cut AKI Risk

Buffered Crystalloid Solution Doesn't Cut AKI Risk

Risk of developing acute kidney injury similar with buffered crystalloid, saline.

Adding Beta-Lactams to Vancomycin Raises AKI Risk

Adding Beta-Lactams to Vancomycin Raises AKI Risk

New studies may clarify the risks associated with antibiotic combinations that include vancomycin, a drug with well-known nephrotoxicities.

Researchers Zero In on Cause of 'Mesoamerican Nephropathy'

Researchers Zero In on Cause of 'Mesoamerican Nephropathy'

Study of sugarcane workers in Nicaragua may help to explain a high prevalence of chronic kidney disease in Central America.

Risk Factors for Aminoglycoside-Induced AKI Identified

Risk Factors for Aminoglycoside-Induced AKI Identified

These factors include a history of heart failure, which was associated with 3-fold increased odds of acute kidney injury.

High Uric Acid at Hospital Admission Raises Acute Kidney Injury Risk

High Uric Acid at Hospital Admission Raises Acute Kidney Injury Risk

A uric acid level above 9.4 mg/dL at admission is associated with 79% increased odds of AKI compared with a level of 5.8-7.6 mg/dL.

AKI Risk Lower with Propofol for ICU Sedation

AKI Risk Lower with Propofol for ICU Sedation

It is associated with a lower risk of adverse renal outcomes compared with midazolam.

Predictors of Recurrent Acute Kidney Injury Identified

Predictors of Recurrent Acute Kidney Injury Identified

Risk factors include longer duration of AKI and hospitalization for congestive heart failure, acute coronary syndrome, and decompensated advanced liver disease.

Men Increasingly Using Legal Performance-Enhancing Drugs

Men Increasingly Using Legal Performance-Enhancing Drugs

Remarkably, 40% of men report an increase in use of performance-enhancing supplements; 29% are also concerned about their use.

AKI Is a Risk Factor for Elevated BP

AKI Is a Risk Factor for Elevated BP

Acute kidney injury is associated with a signi­ficant 22% increased odds of subsequence development of a blood pressure higher than 140/90 mm Hg.

Renal Replacement Need After Cardiac Surgery Hikes Death Risk

Renal Replacement Need After Cardiac Surgery Hikes Death Risk

In a study, 86% of patients who survived experienced renal recovery within 1 year.

Acute Kidney Injury Implicated in Nearly One-Third of Post-PCI Deaths

Acute Kidney Injury Implicated in Nearly One-Third of Post-PCI Deaths

Study findings show that contrast dosing is only a minor contributor to the overall burden of AKI.

Adverse Events Common During Continuous Renal Replacement Therapy

Adverse Events Common During Continuous Renal Replacement Therapy

In a study, the incidence of hyperphosphatemia, ionized hypocalcemia, and ionized hypercalcemia was 44%, 22%, and 23%, respectively.

Remote Ischemic Preconditioning Reduces Surgery-related AKI

Remote Ischemic Preconditioning Reduces Surgery-related AKI

Findings among patients at high risk of acute kidney injury, undergoing cardiac surgery

Acute Kidney Injury Linked to Anabolic Steroids, Supplements

Acute Kidney Injury Linked to Anabolic Steroids, Supplements

AKI developed in bodybuilders who injected anabolic steroids and ingested commercial protein and creatine products.

Acute Kidney Injury Linked to PPIs

Acute Kidney Injury Linked to PPIs

Older users of proton pump inhibitors had a 2-fold increased risk of AKI compared with non-users.

ICU Patients on RRT Rarely Have Nephrology Follow-up

ICU Patients on RRT Rarely Have Nephrology Follow-up

Investigators propose a protocol for when patients should be referred to nephrologists.

Dialysis Modalities Show Similar Outcomes in AKI

Dialysis Modalities Show Similar Outcomes in AKI

Recent meta-analysis compared continuous renal replacement therapy and extended daily dialysis.

Tea Overconsumption Causes Nephropathy

Tea Overconsumption Causes Nephropathy

Excessive consumption of iced tea has been linked to renal failure caused by oxalate nephropathy in a case study appearing in the New England Journal of Medicine.

Synthetic Marijuana Linked to Acute Kidney Injury

Synthetic Marijuana Linked to Acute Kidney Injury

Observational studies strongly support a correlation between synthetic marijuana and kidney damage.

Dialysis for AKI Does Not Hike Risk of Major Cardiovascular Events

Dialysis for AKI Does Not Hike Risk of Major Cardiovascular Events

Absence of association observed in patients with normal or near-normal baseline estimated glomerular filtration rate.

Commission Seeks to End AKI Deaths by 2025

Commission Seeks to End AKI Deaths by 2025

Mission 0by25 hopes to stop preventable deaths from AKI by 2025.

Some Injured Kidneys Suitable for Transplant

Some Injured Kidneys Suitable for Transplant

For reasons that are unclear, certain organs even performed better 6 months after transplant

Vancomycin May Cause Kidney Damage in Children

Vancomycin May Cause Kidney Damage in Children

The higher the dose of vancomycin, the greater the risk, researchers found.

Dialysis-Requiring AKI Quadrupled in ICU Patients

Dialysis-Requiring AKI Quadrupled in ICU Patients

A substantial minority of surviving patients also developed long-term dependence on dialysis.

Higher AKI Rates Suspected After Joint Surgery

Higher AKI Rates Suspected After Joint Surgery

In this Australian study, nearly 15% of hip- or knee-replacement patients experienced acute kidney injury--far higher than previously thought.

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