AKI Risks Not Up With SGLT2 Inhibitors
Findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes.
(HealthDay News) — The risk of acute kidney injury (AKI) is not increased for new sodium-glucose cotransporter-2 (SGLT2) inhibitor users, according to a study published online in Diabetes Care.
Girish N. Nadkarni, MD, from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues assessed the real-world risk of AKI using data for 377 SGLT2 inhibitor users and 377 nonusers in the Mount Sinai chronic kidney disease registry and for 1207 users and 1207 nonusers in the Geisinger Health System cohort.
The researchers found that over a median follow-up of 14 months, 3.8% and 9.7% of SGLT2 users and nonusers in the Mount Sinai cohort, respectively, had an AKIKDIGO event (hazard ratio [HR], 0.4; 95% confidence interval [CI], 0.2 to 0.7; P =.01); the HR was unchanged after adjustment (adjusted HR, 0.4; 95% CI, 0.2 to 0.7; P =.004). Within the Geisinger cohort, 2.2% and 4.6% of users and nonusers, respectively, had an AKI KDIGO event. The unadjusted hazards of AKIKDIGO were lower in users (HR, 0.5; 95% CI, 0.3 to 0.8; P <.01); after adjustment for covariates there was modest attenuation (adjusted HR, 0.6; 95% CI, 0.4 to 1.1; P =.09).
"Our findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes in two large health systems," the authors write.
- Nadkarni GN, Ferrandino R, Chang A, et al. Acute Kidney Injury in Patients on SGLT2 Inhibitors: A Propensity-Matched Analysis. Diabetes Care. 2017 Aug 21. doi: 10.2337/dc17-1011