Generic Name and Formulations:
Aspirin 800mg; pH-dependent release tabs.
Par Pharmaceutical, Inc.
Indications for ZORPRIN:
Rheumatoid arthritis (RA). Juvenile rheumatoid arthritis (JRA). Spondyloarthropathies. Osteoarthritis (OA). Arthritis and pleurisy of systemic lupus erythematosus (SLE).
Swallow whole with ≥8oz of fluids. RA, SLE: initially 3g daily in divided doses; target plasma salicylate level 150–300micrograms/mL. OA: up to 3g/day in divided doses. Spondyloarthropathies: up to 4g/day in divided doses.
<25kg: not recommended. ≥25kg: JRA: initially 90–130mg/kg per day in divided doses; target plasma salicylate level 150–300micrograms/mL.
NSAID allergy. Asthma, rhinitis or nasal polyps. Viral infection in children and teenagers. Children with fever or weigh <25 kg.
Not for antipyresis or short-term analgesia. Severe hepatic or renal dysfunction; avoid. Bleeding disorders. History of GI bleed/peptic ulcer. Diabetes. Gout. Labor and delivery; avoid 1 week before and during. Pregnancy (avoid in 3rd trimester), nursing mothers: not recommended.
Potentiates anticoagulants, oral hypoglycemics, methotrexate, acetazolamide, valproic acid or highly protein-bound drugs. Urinary alkalinizers, antacids, corticosteroids, gastric acid secretion inhibitors may increase excretion. May antagonize ACE inhibitors, β-blockers, diuretics or uricosurics. Increased bleeding risk with anticoagulants, NSAIDs or chronic, heavy alcohol use. NSAIDs increase risk of renal dysfunction.
GI upset/bleed, prolonged bleeding time, anaphylaxis, salicylism (eg, tinnitus), dysrhythmias, agitation, cerebral or pulmonary edema, dehydration, hyperkalemia, elevated hepatic enzymes, angioedema, hyperpnea, Reye's syndrome, coagulopathy, others.
Renal and Urology News Articles
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)