Symptomatic RCC Predicts Worse Survival, Data Show

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Scand J Urol Nephrol. 2008;42:406-411

Patients with symptomatic renal cell carcinoma (RCC) have worse survival than those who have asymptomatic RCC detected incidentally, according to researchers from the Czech Republic.

Investigators from University Hospital Motol in Prague studied a group of 396 RCC patients, of whom 135 (34%) and 261 (66%) presented with incidental and symptomatic tumors, respectively.

Compared with incidental tumors, symptomatic tumors were significantly larger and of higher pathologic stage and grade. Five-year survival in patients with incidental tumors was 88.1% compared with 59.4% for patients with symptomatic tumors.

Five-year survival was 75.4% and 44.4% for patients with local and systemic symptoms, respectively, and 62.2% and 55.6% for patients whose history of tumor-related symptoms was shorter and longer than three months, respectively.

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