Spironolactone Beneficial In Type 2 Diabetic Nephropathy
J Hypertens. 2006;24:2285-2292
Adding spironolactone to an ACE inhibitor or angiotensin II receptor blocker (ARB) is associated with a marked and sustained antiproteinuric effect in type 2 diabetics, researchers in the
Anton H. van den Meiracker, MD, of the
Hyperkalemia developed in five patients in the spiro- nolactone group and one in the placebo group, and these patients had to be excluded. Albuminuria decreased by 40.6% and BP by 7 mm Hg in the spironolactone group but did not change in the placebo group.
During one year of follow-up, estimated glomerular filtration rate declined on average by 12.9 mL/min per 1.73 m2 in the spironolactone group and 4.9 mL/min per 1.73 m2 in the placebo group.