Repeat PSA Tests May Aid Prostate Biopsy Decisions
Eur Urol. 2008;53:777-784
Following an initial PSA test result of 3.0-19.99 ng/mL in men aged 50-70 years, a repeat PSA test within seven weeks allows for more accurate assessment as to whether a biopsy will reveal prostate cancer, a British team reports.
Derek J. Rosario, MD, of the
Men who had a 20% drop in PSA level had a 57% lower risk of prostate cancer and a 71% lower risk of high-grade cancer compared with the rest of the cohort. The effect of percentage reduction was greater among men aged 60 years and younger than in those older than 60 years.
Among men aged 60 years and younger, the 20% drop in PSA translated into a risk reduction of high-grade malignancy from 4% to 0.5%, 6% to 2%, and 15% to 2% when the initial PSA measurement was 3.0-3.99, 4.0-5.99, and 6 ng/mL or higher.