PSA Density Predicts PSA Velocity, UK Study Shows
BJU Int. 2007; published online ahead of print
PSA density is an independent determinant of PSA velocity in untreated localized prostate cancer, a study in the
Chris Parker, MD, and his colleagues at the
PSA density was the only significant determinant of PSA velocity. Patients with a PSA density above the median had a median PSA velocity of 0.92 ng/mL per year; those with a PSA density below the median had a PSA velocity of 0.35 ng/mL per year.
“Subject to validation in prospective studies, PSA density could be used to inform the often difficult choice between active surveillance and immediate radical treatment,” the authors wrote.
The study is the first to show that PSA density is an independent determinant of PSA velocity, the researchers noted.