World Literature Review

Pulmonary Hypertension in HD Patients Increases Death Risk

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Pulmonary hypertension (PHT) independently predicts greater mortality in hemodialysis (HD) patients, Israeli researchers report.

Hip-Fracture-Related Death Linked to CKD in the Elderly

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Among older individuals, an estimated glomerular filtration rate (eGFR) below 45 mL/min/1.73 m2 is associated with a nearly twofold increased risk of hip-fracture-related mortality, according to British researchers.

Intermittent Hormonal Therapy for PCa May Have Benefits

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Intermittent hormonal therapy (IHT) for men with locally advanced and metastatic prostate cancer is associated with no reduction in disease progression or survival, according to a European study.

Fatal Infections Probed in Pediatric LN Patients

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Prior history of treatment with pulse methylprednisolone may increase the risk of fatal infection in pediatric lupus nephritis (LN) patients treated with IV cyclophosphamide (IVCY), researchers reported.

Pulse Pressure, Death Risk Linked in PD Patients

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Elevated pulse pressure is associated with an increased risk of all-cause and cardiovascular death in patients on peritoneal dialysis (PD), according to a Canadian study.

CRP May Predict Survival in Metastatic RCC Patients

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Pretreatment C-reactive protein (CRP) levels can be a prognostic marker for patients with metastatic renal cell carcinoma (RCC), a Japanese study suggests.

Sudden Death Risk Factors in Peritoneal Dialysis Patients Identified

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Recent blood transfusions, male gender, and diabetes mellitus are independently associated with an increased risk of sudden death in patients on peritoneal dialysis (PD), a Chinese study concluded.

Recovery of Sexual Function Possible After Cryosurgery for PCa

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Among prostate cancer patients who had no erectile dysfunction (ED) before undergoing cryosurgery, more than one third recovered full sexual function two years post-operatively, a British study found.

Postlithotripsy Agents Improve Stone Outcomes

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Medical expulsive therapy (MET) following shockwave lithotripsy (SWL) results in a significant increase in successful treatment outcomes, according to Canadian researchers.

Alfuzosin Treatment for BPH Improves Sexual Function

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Patients who receive alfuzosin as treatment for benign prostatic hyperplasia (BPH) experience improvements in sexual function as well lower urinary tract symptoms (LUTS), a South Korean study suggests.

Myocardial Perfusion Found to Decline with Hemodialysis

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Hemodialysis (HD) is associated with a pronounced drop in myocardial perfusion, a study shows.

Current Smokers Diagnosed with Bladder Cancer Earlier

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Bladder cancer is diagnosed about six years earlier in current smokers than in current nonsmokers, according to Japanese investigators.

Hypertension, Acid Excretion Are Linked in Stone Formers

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Kidney stone formers with essential hypertension have increased acid excretion, Italian researchers reported.

Urological Complications Not a Factor in Graft Survival

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Urological complications occur frequently following transplantation of deceased cardiac donor (DCD) kidneys but do not affect graft survival, researchers in the Netherlands have concluded.

Urethral Strictures After HDR Brachytherapy Characterized

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Bulbomembranous (BM) urethral strictures are the most common grade 2 or higher urinary toxicity following high dose rate brachytherapy (HDRB), according to Australian investigators.

Two Modes of Acupuncture May Work for Hot Flushes

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Two modes of acupuncture appear to decrease the number and distress of hot flushes in men receiving castrational treatment for prostate cancer, according to a Swedish study.

Adjuvant Radiotherapy Found Not to Improve PCa Survival

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Adjuvant radiotherapy following radical prostatectomy (RP) for prostate cancer has no effect on overall and cancer-specific survival, a Canadian team reports.

Chemokine Is Identified as a Marker for Acute Rejection

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Measuring levels of the chemokine fractalkine in the urine is a noninvasive way to detect acute rejection of renal allografts, according to Chinese investigators. High levels are associated with steroid resistance and poor outcome.

Jaw Problem in Bisphosphonate Users May Be Underestimated

Bisphosphonate-associated osteonecrosis of the jaw (BP-ONJ) may be an underestimated problem in prostate cancer patients treated with zoledronate, German investigators suggest.

Data Support Epoetin Zeta Use in Hemodialysis Patients

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Data from a German study suggest that IV-administered epoetin zeta—a new erythropoietin preparation—is safe for maintenance treatment of anemia in patients with end-stage renal disease.

Symptomatic RCC Predicts Worse Survival, Data Show

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Patients with symptomatic renal cell carcinoma (RCC) have worse survival than those who have asymptomatic RCC detected incidentally, according to researchers from the Czech Republic.

Predictors of Cardiac Events After Renal Transplantation

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Diabetic nephropathy and CVD prior to renal transplantation are the most important predictors of post-transplant cardiovascular events, researchers in The Netherlands conclude.

MMF Superior For Crescentric Lupus Nephritis, Data Show

Mycophenolate mofetil (MMF) is more effective as induction therapy than cyclophosphamide (CTX) in patients with crescentric lupus nephritis, Chinese investigators report.

Intravesical BCG Should Be Used First for Prophylaxis

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Intravesical instillation of bacillus Calmette-Guérin (BCG) is most effective in the long term when selected as initial prophylactic treatment to prevent recurrence of superficial bladder cancer, according to a Japanese study.

High Alkaline Phosphatase Levels Boost Mortality Risk

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Elevated serum normalized alkaline phosphatase (nAP) is associated with significantly higher risks of hospitalization and death among hemodialysis patients, independent of calcium, phosphorus, and parathyroid hormone levels, ac-cording to a study of patients in 12 countries.

Study: Self-Catheterization Apparently Not a Burden

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Patients do not appear to be burdened by clean intermittent self-catheterization (CISC), according to researchers in Switzerland.

Renal Impairment Increases Risk of Acute Renal Failure

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CKD increases the risk of hospital-acquired acute renal failure (ARF), a study shows. The greater the degree of underlying renal impairment, the greater the ARF risk.

Parenteral Estrogen An Option for Metastatic PCa

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Parenteral estrogen therapy with high-dose polyestradiol phosphate (PEP, Estradurin) has anticancer efficacy similar to that of combined androgen deprivation (CAD) in patients with metastatic prostate cancer, researchers report.

Severe AKI Has Implications for Long-Term Mortality

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Severe acute kidney injury (AKI) is associated with significant long-term mortality, German investigators conclude.

UroVysion Not a Replacement for Cystoscopy, Study Finds

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The UroVysion (UV) assay, which can diagnose urothelial cancer, cannot replace cystoscopy for monitoring patients with non-muscle-invasive bladder cancer. According to researchers in Sweden, the assay may be useful as a supplement to traditional measures for detecting carcinoma in situ (CIS).

Chair Test Measures Physical Functioning in CKD Patients

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Evaluating how predialysis patients rise from a chair may provide a simple way to identify those who need help with muscle training and functional exercise, according to researchers in Sweden and Norway.

Mycophenolate Mofetil Works As Well As Standard Therapy

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Six months of mycophenolate mofetil (MMF) treatment is as effective in the short term as conventional therapy for primary treatment of membranous nephropathy (MN) and focal segmental glomerulosclerosis (FSGS), a pilot study in India found.

Post-Tx Weight Changes May Increase Death Risk

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Patient weight changes after renal transplantation may be a marker for poor survival, data suggest.

PCNL Improves Renal Function in Late-Stage CKD Patients

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Percutaneous nephrolithotomy (PCNL) improves the estimated glomerular filtration rate (eGFR) in patients with stage 5 CKD, but unexpected deterioration in renal function could occur in patients with earlier CKD stages, investigators in Turkey report.

HIFU May Be Feasible Option for Low-Risk Prostate Cancer

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Focal therapy with high-intensity focused ultrasound (HIFU) of localized prostate cancer provides immediate cancer control, comparable to that of other treatment modalities, according to Japanese researchers.

Broad Stroke Risk Benefit From BP-Lowering Observed

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Antihypertensive treatment with perindopril prevents recurrent stroke in CKD patients across a wide spectrum of BP levels, according to Australian and Japanese researchers. They saw no evidence for a higher risk of stroke among individuals with low BP.

Enteric-Coated Mycophenolate Sodium for Lupus Nephritis

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Enteric-coated mycophenolate sodium is effective and well-tolerated in patients with active lupus nephritis, Hong Kong researchers report.

Renal Graft Survival Similar in Elderly, Younger Patients

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Renal transplant recipients have similar death-censored graft survival regardless of age, according to researchers in Norway.

Repeat PSA Tests May Aid Prostate Biopsy Decisions

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Following an initial PSA test result of 3.0-19.99 ng/mL in men aged 50-70 years, a repeat PSA test within seven weeks allows for more accurate assessment as to whether a biopsy will reveal prostate cancer, a British team reports.

Some Patients May Receive Renal Transplants Needlessly

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It may be reasonable to postpone renal transplantation in patients with certain types of renal failure because late recovery of kidney function might occur, according to British researchers.

Alcohol Consumption Cuts ESRD Risk in Chinese Men

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Researchers who studied a large cohort of Chinese men found an inverse relationship between alcohol consumption and end-stage renal disease (ESRD).

Bladder CIS Extent Predicts Post-BCG Disease Progression

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Treatment with bacillus Calmette-Guérin (BCG) is effective for carcinoma in situ (CIS) of the bladder, according to Japanese researchers.

Ascorbate Deficiency Common in Australian PD Patients

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Ascorbate deficiency is common among peritoneal dialysis (PD) patients and can be identified readily with serum ascorbate measurements, researchers in Australia report.

'Remarkably High' Prevalence of CKD Found in Thailand

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Thailand has a "remarkably high" prevalence of CKD among individuals aged 35 years and older, according to Thai and Australian researchers.

HoLEP Efficacy for BPH Increases with Prostate Size

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The efficacy of holmium laser enucleation of the prostate (HoLEP) in the treatment of symptomatic BPH increases with prostate size, according to researchers in India.

Lower BPH Risk Linked to Greater Vegetable Intake

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A diet high in vegetable intake is associated with a lower risk of surgically treated BPH, according to Australian researchers.

High-Grade Prostate Cancer Has a Poor Prognosis

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Patients with Gleason 8-10 prostate tumors have a poor prognosis, according to researchers at the Henri Mondor University Hospital in Créteil, France.

Time on Dialysis Correlates with Delayed Graft Function

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Increasing duration of dialysis is associated with an increased risk of delayed graft function (DGF) following renal transplantation, researchers in Canada have found.

Low Dihydrotestosterone May Decrease PCa Survival

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Low dihydrotestosterone (DHT) may be associated with decreased survival in prostate cancer patients, according to researchers in Sweden.

Urotensin II Predicts Lower Death Risk in CKD Patients

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Elevated plasma levels of urotensin II (UTN) predicts a lower risk of death from all causes and cardiovascular causes in CKD patients, Italian researchers conclude.

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