Calcitriol May Have Role in HRPC Salvage Therapy
BJU Int. 2007; published online ahead of print
High-dose calcitriol and docetaxel, each given separately one day a week for six weeks, appear to be an effective and well-tolerated combination for men living with metastatic hormone-refractory prostate cancer (HRPC) previously treated with docetaxel-based chemotherapy, Italian investigators conclude.
Noting that no standard salvage therapy is available for such patients, the researchers hypothesized that high-dose calcitriol might restore sensitivity to chemotherapy.
Roberto Petrioli, MD, and his colleagues at the
PSA levels declined in eight patients (31%) and remained stable in seven patients (27%) for at least 12 weeks, the researchers reported.