Ascorbate Deficiency Common in Australian PD Patients
Ascorbate deficiency is common among peritoneal dialysis (PD) patients and can be identified readily with serum ascorbate measurements, researchers in
Paolo Ferrari, MD, and his colleagues at the
The researchers obtained follow-up ascorbate levels in 12 stable patients with baseline ascorbate levels below 4 mg/L after a median of three months from baseline. Targeted ascorbate supplementation in these patients increased the median serum ascorbate level from 1.7 to 22.5 mg/L.
The investigators suggest measuring ascorbate levels in all PD patients at the initiation of dialysis, with a target level in the normal range (4-14 mg/L).
“Oral supplements in the form of inexpensive multivitamin preparations restore adequate serum ascorbate levels in the majority of these patients,” the authors concluded. They stated that a supplementation dose of 120 mg as part of a commercial multivitamin preparation appears to be safe and effective at raising ascorbate levels.