Adjuvant Radiotherapy Found Not to Improve PCa Survival

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BJU Int. 2008; published online ahead of print

Adjuvant radiotherapy following radical prostatectomy (RP) for prostate cancer has no effect on overall and cancer-specific survival, a Canadian team reports.

Researchers conducted a matched case-control study comparing 118 men who received post-RP adjuvant radiotherapy with controls who did not. The investigators matched patients for pT stage, RP Gleason sum, surgical margin status, age, year of surgery, and administration of hormonal therapy.

The median follow-up was 11.4 years. The 10- and 20-year overall survival rates were 75.5% and 40%, respectively, for the adjuvant radiotherapy group and 81.1% and 44.8% for controls. The 10- and 20-year cancer-specific survival rates were 86.3% and 69.3% for the adjuvant radiotherapy group and 97.3% and 89% for controls. The differences between the groups were not statistically significant.

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