B. cenocepacia Abundant in Men with Chronic Pelvic Pain

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Species and genus composition differ for men with urologic chronic pelvic pain syndrome, controls.
Species and genus composition differ for men with urologic chronic pelvic pain syndrome, controls.

(HealthDay News) -- Burkholderia cenocepacia is overrepresented in initial stream urine of men with urologic chronic pelvic pain syndrome, according to a study published in The Journal of Urology.

J. Curtis Nickel, M.D., from Queen's University in Kingston, Canada, and colleagues examined microbial etiology in men with urologic chronic pelvic pain. Urine specimens were provided by 110 participants with urologic chronic pelvic pain syndromes and 115 controls. To provide comprehensive identification of bacterial and select fungal species, specimens were analyzed with Ibis T-5000 Universal Biosensor technology.

The researchers detected 78, 73, and 54 species (42, 39, and 27 genera) in initial, midstream, and post-prostatic massage urine specimens, respectively. Per-person, the mean initial, midstream, and post-prostatic massage urine species count was 1.62, 1.38 and 1.33 for cases and 1.75, 1.23, and 1.56 for controls, respectively. In the initial stream urine there was a significant difference in the overall species and genus composition between patients with urologic chronic pelvic pain syndrome and controls (P = 0.002 species level; P = 0.004 genus level). In urologic chronic pelvic pain syndrome, Burkholderia cenocepacia was overrepresented.

"Assessment of baseline culture-independent microbiological data from male subjects enrolled in the MAPP [Multidisciplinary Approach to the Study of Pelvic Pain] Network has identified overrepresentation of Burkholderia cenocepacia in urologic chronic pelvic pain syndrome," the authors write.

Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.

Sources

  1. Nickel, JC, et al. The Journal of Urology, published July 2015, Volume 194, Issue 1, pages 127–135; doi: 10.1016/j.juro.2015.01.037.
  2. Anthony J. Schaeffer. The Journal of Urology, published July 2015, Volume 194, Issue 1; doi: 10.1016/j.juro.2015.04.070.
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