Managing Recurrent UTI in Older Men

Case presented of patient with extended-spectrum beta-lactamase <i>E. coli</i> infection.
Case presented of patient with extended-spectrum beta-lactamase E. coli infection.

(HealthDay News) -- In a case vignette published in the New England Journal of Medicine, recommendations are presented for management of recurrent acute febrile urinary tract infections in older men.

Anthony J. Schaeffer, MD, from the Northwestern University Feinberg School of Medicine in Chicago, and Lindsay E. Nicolle, MD, from the University of Manitoba in Winnipeg, Canada, discuss evaluation and management of a case of a 79-year-old man with extended-spectrum beta-lactamase Escherichia coli. The patient had a similar infection several months earlier, with the same organism isolated.

The authors note that the patient described in the vignette had chronic bacterial prostatitis with extended spectrum beta-lactamase E. coli infection. A referral to a urologist for cultures to localize the infection to the prostate was recommended. Correction should be considered if abnormalities are identified on upper urinary tract imaging. A 30-day course is recommended if testing to localize the infection to the prostate is positive and the organism is sensitive to fluoroquinolone or trimethoprim-sulfamethoxazole. Alternative agents that penetrate the prostate may be considered if the bacteria are not sensitive to these agents. Watchful waiting, intermittent self-initiated therapy, or suppressive therapy should be considered if initial therapy fails or relapse occurs. If the patient is prescribed long-term suppressive therapy, the dose and frequency should be adjusted to a level that would be adequate to prevent recurrent symptoms of urinary tract infections.

"The patient should be aware of potential adverse effects of long-term antimicrobial therapy," the authors write.

One author disclosed financial ties to the biopharmaceutical industry.

Source

  1. Schaeffer AJ and Nicolle LE. Urinary Tract Infections in Older Men. N Engl J Med 2016;374:562-571. doi:10.1056/NEJMcp1503950.
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