Lower-Dose Oxychlorosene Better for UTIs

DENVER—Bladder irrigation with lower-strength oxychlorosene may be a better option for treating urinary tract infections (UTIs) than the concentration traditionally used because it is just as effective and it causes fewer adverse effects, according to study findings presented at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy.

Oxychlorosene is an antiseptic agent that may beused to treat UTIs, but the optimal treatment regimen has yet to be defined, said study investigator Andrea Stock, PharmD, a practicing pharmacist at the Franciscan St. Francis Health in Indianapolis, Ind.  Dr. Stock and her colleagues retrospectively compared oxychlorosene 0.2% and 0.05% in the treatment of UTIs in 150 patients. 

Fifty patients with a mean age of 73 years received 0.2% oxychlorosene and 100 patients with a mean age of 69 years received 0.05% oxychlorosene. The clinical success rates were similar—90% for patients treated with the 0.2% solution and 96% for those who received the 0.05% solution—but the recipients of the lower-concentration of oxychlorosene reported fewer adverse effects.

Adverse events were reported by two patients (2%) in 0.05% group and four patients (8%) receiving the higher dose.  “Because it is a locally acting agent we did not see any systemic adverse effects, which is what you would expect,” Dr. Stock said.

As the prevalence of multi-drug resistant (MDR) pathogens has been steadily increasing in recent years, so has the use of oxychlorosene, she said. This agent had previously demonstrated excellent in vitro activity against MDR pathogens. Oxychlorosene 0.2% bladder irrigation has traditionally been used for UTI treatment, but patients have reported more pain and discomfort more frequently when receiving this solution.

In vitro data have suggested that oxychlorosene is effective at concentrations much lower than 0.2%.

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