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TWINRIX
Vaccines
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Drug Name:

TWINRIX Rx

Generic Name and Formulations:
Hepatitis A inactivated 720 ELISA Units (EL.U.), hepatitis B surface antigen (recombinant) 20mcg; per mL; susp for IM inj; aluminum adsorbed; contains trace amounts of thimerosal, formalin, neomycin, yeast protein.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for TWINRIX:

Hepatitis A and hepatitis B immunization.

Adult:

≥18yrs: 1 inj IM in deltoid area at 0-, 1-, and 6 months. Alternate 4-dose schedule: 1 inj IM in deltoid area at 0-, 7-, and 21 to 30-days followed by booster dose at month 12.

Children:

<18yrs: not recommended.

Warnings/Precautions:

May defer in acute febrile illness or active infection. Bleeding disorders. Thrombocytopenia. Immunodeficiency: may get suboptimal response. Have epinephrine (1:1000) inj available. If given with immune globulin, use separate syringe and different site. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Immunosuppressives may reduce efficacy.

Adverse Reactions:

Inj site reactions, headache, fatigue, GI upset, fever.

Note:

Register pregnant patients exposed to Twinrix by calling (888) 452-9622. Report adverse events to VAERS by calling (800) 822-7967.

How Supplied:

Single-dose vials—1, 10; Single-dose prefilled syringes—5

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