Transplantation

Kidney Transplant Outcomes Unaffected by Dialysis Modality

Kidney Transplant Outcomes Unaffected by Dialysis Modality

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Patient and graft survival are similar for patients who were on hemodialysis and peritoneal dialysis prior to transplantation.

Kidney Donor Candidates May Have Various Incidentally Detected Lesions

Kidney Donor Candidates May Have Various Incidentally Detected Lesions

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Potential donors undergoing multidetector computed tomography during their assessment should be counseled on the medical implications of incidentally discovered lesions.

Using HCV-infected kidneys greatly reduces wait time for transplantation and improves survival for patients with HCV

1. Use of HCV-infected kidneys increased patients' quality-adjusted life expectancy. 2. Lower costs were associated with HCV-infected kidneys compared to transplanting HCV-uninfected kidneys to HCV-positive patients. Evidence Rating Level: 2 (Good) Study Rundown: Organ availability for transplantation is limited; therefore, for patients with end stage renal disease (ESRD), hemodialysis is often the final treatment compared []

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

Good Outcomes for HCV-Negative Recipients of HCV Kidneys

All 20 recipients experienced HCV cure, good quality of life, excellent renal function.

Progress in Graft Survival Has Slowed

Progress in Graft Survival Has Slowed

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After 2000, investigators observed a deceleration in short-term improvements in graft survival.

Patient Social Support Influential Factor for Transplant Providers

Patient Social Support Influential Factor for Transplant Providers

Recipient social support most influential factor for providers concerned with avoiding organ wastage.

HCV-Infected Kidney Transplant More Efficient in HCV-Infected

HCV-Infected Kidney Transplant More Efficient in HCV-Infected

Increases quality-adjusted life expectancy, reduces costs versus transplant of HCV-uninfected kidney.

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

From pre- to post-expansion period, 59% relative increase in Medicaid-covered preemptive listings.

Pediatric Kidney Recipients Often Have Subclinical Inflammation

Pediatric Kidney Recipients Often Have Subclinical Inflammation

Associated with increased risk of composite end point of acute rejection, allograft failure.

Sun Defenses Up in Transplant Patients After Skin Cancer Study

Sun Defenses Up in Transplant Patients After Skin Cancer Study

Increased odds of using multiple sun protection measures among organ transplant recipients.

Post-Transplant Tx Reduces Wait for Kidney in Hep C+ Patients

Post-Transplant Tx Reduces Wait for Kidney in Hep C+ Patients

Delaying treatment until after transplant doesn't adversely impact kidney allograft or survival.

Remaining Kidney Health Most Important Concern for Donors

Remaining Kidney Health Most Important Concern for Donors

Other concerns expressed by living donors include surgical, lifestyle, psychosocial impact of donation.

Proportion of Drug-Intoxicated Organ Donors on the Rise in US

Proportion of Drug-Intoxicated Organ Donors on the Rise in US

No difference in survival between recipients of organs from drug-intoxicated donors, other donors.

Bladder Cancer, UTUC More Common in Kidney Transplant Recipients

Bladder Cancer, UTUC More Common in Kidney Transplant Recipients

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A study found that bladder cancer and UTUC occurred in 122.22 and 113.97 per 100,000 persons per year, respectively, among kidney transplant recipients.

Liver-Kidney Recipients Have Donor-Specific Hypo-Responses

Liver-Kidney Recipients Have Donor-Specific Hypo-Responses

Unique characteristics ID'd in peripheral blood cells of simultaneous liver-kidney transplant recipients.

Optimizing organ donations from overdose deaths may help address national organ shortage

1. U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs). 2. Compared to TDD organs, ODD kidneys and livers were discarded at a greater rate. Evidence Rating []

Organ Transplants Involving Overdose-Death Donors Increasing

Organ Transplants Involving Overdose-Death Donors Increasing

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The number of transplants in the United States involving organs from individuals who died from a drug overdose rose from 149 in 2000 to 3533 in 2016.

Many Providers Unaware of Racial Disparities in Kidney Transplants

Many Providers Unaware of Racial Disparities in Kidney Transplants

Nurse managers, white providers more likely to be unaware of national racial disparity in waitlisting

Renal Allograft Failure Linked to Low Uromodulin Levels

Renal Allograft Failure Linked to Low Uromodulin Levels

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Kidney transplant recipients in the highest tertile of serum uromodulin concentration had a 2-fold increased risk of allograft failure compared with those in the lowest tertile.

Large Drop Seen in Infection-Related Post-Transplant Deaths

Large Drop Seen in Infection-Related Post-Transplant Deaths

Findings among adults undergoing kidney transplantation in Finland 1990 to 2010

Organ Donation Decision Not Linked to Family Grief

Organ Donation Decision Not Linked to Family Grief

Families making decision not to donate relative's organs experience lower quality communication

Navigators Improve Kidney Transplant Waitlisting Process

Navigators Improve Kidney Transplant Waitlisting Process

However, the impact in waitlisting was only seen for disadvantaged after 500 days of follow-up.

Living Kidney Donation Among Men Declined

Living Kidney Donation Among Men Declined

Incidence of donation stable in women but decreased among men; income tied to changes in donation

HCV Prophylaxis Could Expand Kidney Availability

HCV Prophylaxis Could Expand Kidney Availability

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In a small study, direct-acting prophylaxis against hepatitis C virus (HCV) appeared safe and well-tolerated in uninfected recipients of HCV+ kidneys.

HCV-infected kidney donors could save lives

1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for patients with kidney []

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

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Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

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Patients who have a failed renal allograft removed prior to undergoing another kidney transplant may be at increased risk of losing the new allograft, according to a new review.

Incidental Discovery of Health Issues May Benefit Living Kidney Donors

Incidental Discovery of Health Issues May Benefit Living Kidney Donors

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The living kidney donor candidate evaluation process can reveal serious undiagnosed medical problems.

Living kidney donation associated with some increased health risks

1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD). 2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced quality of life, or mortality. []

Death, CVD, Type 2 Diabetes Not Increased for Living Kidney Donors

Death, CVD, Type 2 Diabetes Not Increased for Living Kidney Donors

Increased risks for ESRD, preeclampsia, although absolute risk of these outcomes remains low.

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