Transplantation

Optimizing organ donations from overdose deaths may help address national organ shortage

1. U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs). 2. Compared to TDD organs, ODD kidneys and livers were discarded at a greater rate. Evidence Rating []

Organ Transplants Involving Overdose-Death Donors Increasing

Organ Transplants Involving Overdose-Death Donors Increasing

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The number of transplants in the United States involving organs from individuals who died from a drug overdose rose from 149 in 2000 to 3533 in 2016.

Many Providers Unaware of Racial Disparities in Kidney Transplants

Many Providers Unaware of Racial Disparities in Kidney Transplants

Nurse managers, white providers more likely to be unaware of national racial disparity in waitlisting

Renal Allograft Failure Linked to Low Uromodulin Levels

Renal Allograft Failure Linked to Low Uromodulin Levels

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Kidney transplant recipients in the highest tertile of serum uromodulin concentration had a 2-fold increased risk of allograft failure compared with those in the lowest tertile.

Large Drop Seen in Infection-Related Post-Transplant Deaths

Large Drop Seen in Infection-Related Post-Transplant Deaths

Findings among adults undergoing kidney transplantation in Finland 1990 to 2010

Organ Donation Decision Not Linked to Family Grief

Organ Donation Decision Not Linked to Family Grief

Families making decision not to donate relative's organs experience lower quality communication

Navigators Improve Kidney Transplant Waitlisting Process

Navigators Improve Kidney Transplant Waitlisting Process

However, the impact in waitlisting was only seen for disadvantaged after 500 days of follow-up.

Living Kidney Donation Among Men Declined

Living Kidney Donation Among Men Declined

Incidence of donation stable in women but decreased among men; income tied to changes in donation

HCV Prophylaxis Could Expand Kidney Availability

HCV Prophylaxis Could Expand Kidney Availability

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In a small study, direct-acting prophylaxis against hepatitis C virus (HCV) appeared safe and well-tolerated in uninfected recipients of HCV+ kidneys.

HCV-infected kidney donors could save lives

1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for patients with kidney []

Renal Replacement Therapy Trends in ADPKD Characterized

Renal Replacement Therapy Trends in ADPKD Characterized

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Patients with end-stage renal disease (ESRD) due to autosomal polycystic kidney disease are more likely to receive a kidney transplant than those with ESRD from other causes, new study finds.

Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

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Patients who have a failed renal allograft removed prior to undergoing another kidney transplant may be at increased risk of losing the new allograft, according to a new review.

Incidental Discovery of Health Issues May Benefit Living Kidney Donors

Incidental Discovery of Health Issues May Benefit Living Kidney Donors

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The living kidney donor candidate evaluation process can reveal serious undiagnosed medical problems.

Living kidney donation associated with some increased health risks

1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD). 2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced quality of life, or mortality. []

Death, CVD, Type 2 Diabetes Not Increased for Living Kidney Donors

Death, CVD, Type 2 Diabetes Not Increased for Living Kidney Donors

Increased risks for ESRD, preeclampsia, although absolute risk of these outcomes remains low.

Method Gauges Transplant Referral Among Dialysis Facilities

Method Gauges Transplant Referral Among Dialysis Facilities

Standardized transplantation referral ratio shows most variation is due to within-facility characteristics.

Living Kidney Donors Need Support for Range of Emotions

Living Kidney Donors Need Support for Range of Emotions

Support, clear communication from health care team essential for improving donor comfort level.

Are Doctors Discarding Suitable Kidneys?

Are Doctors Discarding Suitable Kidneys?

Less than perfect older kidneys may still be suitable for transplantation.

Robotic Kidney Transplantation Safe, Feasible

Robotic Kidney Transplantation Safe, Feasible

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Robotic-assisted kidney transplantation is associated with a low complication rate and excellent graft function, European study shows.

Racial-Ethnic Gap in Living Donor Kidney Transplantation Widens

Racial-Ethnic Gap in Living Donor Kidney Transplantation Widens

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New findings suggest that national strategies have failed to correct racial/ethnic disparities in live donor kidney transplantation.

Excess Death Risk in ESRD Has Declined

Excess Death Risk in ESRD Has Declined

Decrease in excess risk of all-cause mortality from 1995 to 2013 for those with end-stage renal disease.

Targeting Ups Nanoparticle Accumulation in Graft Endothelial Cells

Targeting Ups Nanoparticle Accumulation in Graft Endothelial Cells

Altering the surface of an anti-CD31 antibody helps NPs administer therapeutics to ECs.

Variables Affecting Deceased-Donor Kidney Acceptance Rates

Variables Affecting Deceased-Donor Kidney Acceptance Rates

Data that shed light on the allograft decision process may ultimately help transplant teams navigate their expanding waiting lists.

Monoclonal Antibodies Reduce Injury of Renal Allografts

Monoclonal Antibodies Reduce Injury of Renal Allografts

In animal model, anti-CD47 monoclonal antibody group had decease in injury of renal allografts.

Nonmedical Attributes Tied to Later Kidney Transplant Waits

Nonmedical Attributes Tied to Later Kidney Transplant Waits

African-Americans less likely to be wait-listed; higher income positively associated with wait-listing.

Causes of Most Kidney Transplant Patient Deaths Reported as Unknown

Causes of Most Kidney Transplant Patient Deaths Reported as Unknown

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Among kidney transplant recipients who died with a functioning graft, the cause of death was reported as unknown for 64% of them.

Intensive Home HD, Deceased-Donor Transplants Offer Similar Survival

Intensive Home HD, Deceased-Donor Transplants Offer Similar Survival

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After adjusting for confounders, patients on intensive home hemodialysis and recipients of deceased-donor kidneys showed no significant difference in death risk

Kidney Graft Loss Risk Not Associated With Vitamin D Deficiency

Kidney Graft Loss Risk Not Associated With Vitamin D Deficiency

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In a study 383 kidney transplant recipients, low levels of 25-hydroxyvitamin D were not associated with an increased risk of graft loss following transplantation.

Skin Cancer After Organ Transplant Declining

Skin Cancer After Organ Transplant Declining

Standardized incidence ratio peaked in patients who underwent transplantation in 1983-1987 period.

Melanoma Staging System Updated

Melanoma Staging System Updated

Key changes include new N category descriptors, more stage III subgroups, new M1D designation.

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