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Transplantation

Hospital Not Liable for Kidney Transplant Cancer Death

Ann W. Latner, JD July 28, 2010

Physicians at a New York hospital have been found not liable for the death of a 37-year old man who died from cancer and receiving a kidney from a woman who had uterine cancer.

UTI Pathogens Differ in Renal Transplant Patients

Jody A. Charnow June 27, 2010

MUNICH, GERMANY—Urinary tract infections (UTIs) caused by non-coliform bacteria are significantly more common among renal transplant patients compared with the general population, according to a British study.

Increased Hypertension Risk Found in Live Kidney Donors

Jody A. Charnow June 26, 2010

MUNICH, GERMANY—Live kidney donors may experience an increase in blood pressure following nephrectomy, new data suggest.

Lower Dosage Strength Sirolimus Tablets Available

Jody A. Charnow June 14, 2010

A lower dosage strength sirolimus (Rapamune) tablet is now commercially available, according to the drug's maker, Pfizer Inc., of New York.

Anti-Rejection Therapies Carry Similar Cancer Risks

Delicia Honen Yard May 24, 2010

The increased risk of cancer among renal transplant patients is similar across various immunosuppressant therapies, according to an Australian study published online in the Journal of the American Society of Nephrology.

Everolimus Okayed for Preventing Renal Transplant Rejection

Jody A. Charnow May 21, 2010

Novartis Pharmaceuticals, based in East Hanover, NJ, has received FDA approval of Zortress (everolimus) oral tablets for preventing rejection of kidney transplants in adult patients at low-to-moderate immunologic risk.

Donor Gene Variant Predict Kidney Graft Success

Delicia Honen Yard May 21, 2010

Particular variations of the CAV1 gene in a kidney donor may determine the success of a kidney transplant. A new analysis uncovered significant differences in graft survival according to donor genotypes of CAV1, which has a role in tissue fibrosis and vascular proliferation.

Donor Kidney Volume May Predict Post-Tx Function at One Year

Jody A. Charnow May 06, 2010

SAN DIEGO—Donor kidney volume is a major determinant of allograft kidney function one year after renal transplantation, according to researchers.

Donor Race May Affect Survival of HCV-Infected Renal Transplant Patients

Jody A. Charnow May 04, 2010

SAN DIEGO—Non-black renal transplant patients infected with the hepatitis C virus (HCV) have better survival if they receive a kidney from a non-black rather than a black donor, data show.

Mortality Linked to Duration of Delayed Graft Function

Jody A. Charnow May 04, 2010

SAN DIEGO—The duration of delayed graft function (DGF) influences mortality risk among renal transplant recipients surviving 90 days after transplantation, a study found.

AKI Need Not Rule Out Kidney Donation

Jody A. Charnow May 04, 2010

SAN DIEGO—Deceased donor kidneys with acute kidney injury (AKI) offer excellent short term patient and graft survival, investigators reported here at the 2010 American Transplant Congress.

ECD Factors Affecting Graft Outcomes Identified

Jody A. Charnow May 03, 2010

SAN DIEGO—Recipients of kidneys from expanded criteria donors (ECDs) with elevated terminal creatinine may be at higher risk for delayed graft function (DGF) and primary nonfunction (PNF), according to researchers at Mount Sinai School of Medicine in New York.

Low-Dose Fluconazole Prophylaxis After Renal Transplantation is Safe and Effective

Jody A. Charnow May 03, 2010

SAN DIEGO—Low-dose fluconazole is safe and highly effective for antifungal prophylaxis after kidney transplantation, according to a study conducted by researchers at University of Utah Health Care in Salt Lake City.

New-Onset Diabetes Linked to Post-Transplant Hypomagnesemia

Jody A. Charnow May 02, 2010

SAN DIEGO—Hypomagnesemia in the first three months following renal transplantation may be a risk factor for the development of rapid new-onset type 2 diabetes (NODAT), according to researchers.

Post-Transplant Weight Gain May Be Unrelated to Dietary Intake

Jody A. Charnow May 02, 2010

SAN DIEGO—Patients who undergo renal transplantation can experience significant weight gain in the first six months after the procedure, and the reason may not be related to changes in dietary intake, researchers reported here at the 2010 American Transplant Congress.

Everolimus Okayed for Preventing Renal Transplant Rejection

Jody A. Charnow April 22, 2010

Cinacalcet Effective for Persistent Post-Transplant HPT

John Schieszer April 15, 2010

Cinacalcet appears to be a safe and effective agent in the long-term management of persistent post renal transplant hyperparathyroidism. Researchers at the State University of New York-Stony Brook found that this therapy on a long-term basis produced no deleterious impact on renal function after a three-year follow-up presented at the National Kidney Foundation's 2010 Spring Clinical Meetings .

Black Transplant Recipients on Rapamycin Less Likely to Die

Jody A. Charnow April 15, 2010

Black renal transplant recipients receiving immunosuppression with rapamycin live longer than whites receiving the same drug, according to a study presented at the National Kidney Foundation's 2010 Spring Clinical Meetings.

HCV-Infected Kidneys May Help HCV-Infected Recipients

Delicia Honen Yard April 09, 2010

Although kidneys infected with hepatitis C virus (HCV) were 2.6 times more likely than HCV-free donor kidneys to be discarded than used for transplantation, HCV-positive patients may well derive some benefit from receiving these organs, according to a report in the American Journal of Transplantation (online ahead of print).

Belatacept May Improve Transplant Outcomes

John Schieszer April 01, 2010

Belatacept may be better than calcineurin inhibitors (CNIs) at improving renal function in kidney transplant recipients, according to a new study.

Study: Paying For Kidneys Is Ethical

Jody A. Charnow April 01, 2010

Payments for live donor kidneys would increase the number of kidneys available to strangers on transplant waiting lists without causing undue and unjust inducements to donors, according to a study.

Most Renal Transplant Candidates Would Accept Viral Risks

Jody A. Charnow March 30, 2010

Most renal transplant recipients would accept a kidney from a donor at increased risk for viral infections (DIRVI), a new study found.

High-Risk Donors May Need to Be Redefined

John Schieszer March 30, 2010

Nucleic acid testing has greatly shortened the time it takes to detect infections in potential donors.

Transplants Can Proceed Despite Substance Abuse

John Schieszer March 30, 2010

FORT LAUDERDALE—Substance abuse by renal transplant recipients does not significantly affect graft and patient outcomes, according to data presented at the American Society of Transplant Surgeons 10th Annual State of the Art Winter Symposium.

Kidney Allocation Policy May Need Rethinking

John Schieszer March 30, 2010

De-emphasis on HLA matching could lead to worse outcomes in highly sensitized patients

Improved Immunosuppression in African Americans

John Schieszer March 30, 2010

FORT LAUDERDALE—Steroid-free immunosuppression in African-American (AA) renal transplant recipients using alemtuzumab induction with low-dose tacrolimus and mycophenolate (FK/MMF) maintenance may be done safely and successfully, according to researchers.

Renal Resistance Could Improve Organ Evaluation

John Schieszer March 30, 2010

FORT LAUDERDALE, Fla.—Renal resistance after three hours of machine perfusion may be a more sensitive marker than renal histology for predicting allograft survival, researchers reported.

Preoperative Embolization May Offer Benefits

John Schieszer March 30, 2010

Angiographic kidney embolization before allograft nephrectomy reduced blood loss, cut operating time.

Post-Transplant Fungal Infections Remain Problematic

Jody A. Charnow March 30, 2010

Fungal infections, especially invasive candidiasis and invasive aspergillosis, remain problematic among solid organ transplant recipients (SOT), but overall mortality appears to have improved, new findings confirm.

Immune Cells Predict Post-Transplant Skin Cancer

Delicia Honen Yard March 26, 2010

The risk of skin cancer after kidney transplantation was more than five times higher in patients with high levels of T-regulatory immune cells and low levels of "natural killer" immune cells.