PCSK9 Linked to New-Onset Diabetes After Kidney Transplantation

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NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.
NODAT occurred more frequently in the upper PCSK9 tertile vs the lowest two PCSK9 tertiles.

(HealthDay News) — For renal transplant recipients (RTRs) without diabetes, circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with new-onset diabetes after transplantation (NODAT), according to a study published online in Diabetes Care.

Michele F. Eisenga, MD, from the University of Groningen in the Netherlands, and colleagues examined the correlation between serum PCSK9 levels and NODAT development among RTRs without diabetes with a functional graft for at least 1 year.

Serum PCSK9 was 107.1 ± 43.4 µg/L in 453 RTRs. The researchers found that 70 RTRs developed NODAT, 123 died, and 59 developed graft failure during a median follow-up of 10 years. NODAT occurred more often in the upper vs the 2 lowest tertiles of PCSK9 (23% vs 12%; P <.001). PCSK9 correlated with the development of NODAT (hazard ratio, 1.34; 95% confidence interval, 1.10 to 1.63 per standard deviation change; P =.004). The correlation was independent of confounding variables, including statin use. There was no correlation for PCSK9 with all-cause mortality, cardiovascular mortality, or graft failure.

"Circulating PCSK9 is associated with NODAT in RTRs," the authors write. "The PCSK9 pathway may contribute to the pathogenesis of NODAT."

PCSK9 was measured at Lilly Research Laboratories (Eli Lilly and Company) for free.

Reference

  1. Eisenga MF, Zelle DM, Sloan JH, et al. High Serum PCSK9 Is Associated With Increased Risk of New-Onset Diabetes After Transplantation in Renal Transplant Recipients. Diabetes Care. 1 May 2017. doi: 10.2337/dc16-2258
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